Abstract：【Objective】 To explore the risk factors for pregnancy with subclinical hypothyroidism (SCH) and its influence on maternal-infant outcome.【Methods】 A total of 200 pregnant women with SCH receiving prenatal examination in the hospital from January 2017 to May 2018 were selected as the research group and 200 cases of non SCH were selected as the control group. The incidence rates of complications and pregnancy outcomes in these groups were observed. Univariate logistic regression analysis and multivariate logistic regression analysis were used to analyze age, pre-pregnancy body mass index(BMI) and educational level as well as the risk factors of pregnancy complicated with SCH. 【Results】 The incidence rates of gestational diabetes mellitus,anemia,and premature rupture of fetal membranes in the research group were significantly higher than those in the control group(P＜0.05).The incidence rates of abortion, preterm birth, stillbirth in the research group were significantly higher than those in the control group(P＜0.05).Univariate logistic regression analysis showed that age, pre-pregnancy BMI, education level, history of gestation, history of spontaneous abortion and smoking or exposure to smoking environment were correlated with pregnancy complicated with SCH (P＜0.05).Multivariate logistic regression analysis showed that age-≥30 years, primiparity, pre-pregnancy BMI＜18kg/m2 were risk factors of pregnancy complicated with SCH (P＜0.05). 【Conclusion】 Pregnancy combined with subclinical hypothyroidism can lead to various complications, resulting in various adverse events, which seriously affects the safety of mother and child. In clinical, early detection and intervention should be made.
刘艳秋, , 白雪利, 张曙萱. 妊娠合并亚临床甲状腺功能减退的危险因素及其对母婴结局的影响[J]. 医学临床研究, 2018, 35(12): 2329-2331.
LIU Yan-qiu, BAI Xue-li, ZHANG Shu-xuan. Risk Factors for Pregnancy with Subclinical Hypothyroidism and Its Effect on Maternal-infant outcomes. JOURNAL OF CLINICAL RESEARCH, 2018, 35(12): 2329-2331.
2018, Vol. 35 
