Abstract：【Objective】 To study the effect of hydromorphone on patient-controlled epidural analgesia (PCEA) after knee arthroplasty in elderly patients.【Methods】 Ninety-two elderly patients undergoing knee arthroplasty in Guizhou Orthopaedic Hospital (August 2015 to December 2016) were divided into two groups by random digital table. All the patients were operated under combined spinal-epidural anesthesia. The patients in the control group were treated with sufentanil for patient-controlled analgesia, and the patients in the observation group were treated with hydromorphone hydrochloride for patient-controlled analgesia. 【Results】 The number of pain pump compression at 24 hours after operation in the observation group was less than that in the control group, but there was no significant difference between the observation group and the control group in the number of pain pump compressions and the Ramsay score at 48 hours after operation (P>0.05). VAS scores in the observation group were significantly lower than those in the control group (P<0.05). There was no significant difference in the level of TNF- α, NE and Cor between the two groups before operation (P>0.05). The level of TNF- α, NE and Cor in the observation group was lower than those in the control group at 24 hours and 72 hours after operation. There was statistical significance (P<0.05). There was no significant difference in the adverse reaction rate between the two groups (P>0.05). 【Conclusion】 The analgesic effect of hydromorphone in elderly patients after knee arthroplasty is significant. It can relieve inflammatory injury and stress reaction and is safe.
韩锐. 氢吗啡酮用于老年膝关节置换术后自控镇痛的临床研究[J]. 医学临床研究, 2018, 35(9): 1669-1671.
HAN Rui. Effect of Hydromorphone on Patient-Controlled Analgesia after Knee Arthroplasty in Elderly Patients. JOURNAL OF CLINICAL RESEARCH, 2018, 35(9): 1669-1671.
2018, Vol. 35 
