肾细胞癌组织中RAGE、LOXL2蛋白的表达及其临床意义

doi:10.3969/j.issn.1671-7171.2024.09.006

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摘要【目的】探讨肾细胞癌组织中晚期糖基化终末产物受体(RAGE)、赖氨酰氧化酶样蛋白2(LOXL2)蛋白的表达及其临床意义。【方法】收集152例拟行手术治疗的肾细胞癌患者的临床资料,分析癌组织中RAGE、LOXL2表达与患者临床病理特征的关系。根据患者术后5年内是否死亡分为死亡组与存活组,对比两组临床资料,分析患者术后5年内死亡的影响因素及RAGE、LOXL2阳性与阴性患者生存曲线的差异。【结果】肾细胞癌组织中RAGE、LOXL2阳性率均高于癌旁组织(P<0.05);RAGE与LOXL2阳性表达情况与肿瘤分化程度、肿瘤分期、淋巴结是否转移有关(P<0.05),与年龄、性别、肿瘤直径、肾包膜是否受侵无关(P>0.05)。死亡组年龄、淋巴结转移、LOXL2阳性、RAGE阳性例数占比高于存活组(P<0.05)。淋巴结转移、RAGE阳性、LOXL2阳性为患者术后5年内死亡的危险因素(P<0.05)。RAGE 及LOXL2的阴性与阳性患者的生存曲线比较,差异有统计学意义(P<0.05)。【结论】肾细胞癌组织中RAGE、LOXL2阳性率较高,与肿瘤分化程度、肿瘤分期、淋巴结转移情况有关,RAGE与LOXL2表达呈正相关,检测二者有助于评估患者预后。

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	宋芝峰

关键词 ：癌,肾细胞/病理学, S100A12蛋白质

Abstract：【Objective】To investigate the expression and clinical significance of the receptor for advanced glycation end products (RAGE) and lysyl oxidase-like protein 2 (LOXL2) in renal cell carcinoma tissues.【Methods】Clinical data were collected from 152 patients with renal cell carcinoma who were scheduled for surgical treatment. The relationship between the expression of RAGE and LOXL2 in cancer tissues and the clinicopathological characteristics of the patients was analyzed. Patients were divided into a death group and a survival group based on whether they died within 5 years postoperatively. Clinical data between the two groups were compared, and factors influencing death within 5 years postoperatively were analyzed, as well as differences in survival curves between RAGE and LOXL2 positive and negative patients.【Results】The positive rates of RAGE and LOXL2 in renal cell carcinoma tissues were higher than those in adjacent tissues (P<0.05). The expression of RAGE and LOXL2 was related to tumor differentiation, tumor stage, and lymph node metastasis (P<0.05), but not to age, gender, tumor diameter, or renal capsule invasion (P>0.05). The proportion of age, lymph node metastasis, LOXL2 positivity, and RAGE positivity in the death group was higher than that in the survival group (P<0.05). Lymph node metastasis, RAGE positivity, and LOXL2 positivity were influencing factors for death within 5 years after surgery (P<0.05).【Conclusion】The positive rates of RAGE and LOXL2 in renal cell carcinoma tissues are high and they are related to tumor differentiation, tumor stage, and lymph node metastasis. RAGE and LOXL2 are positively correlated, and their detections can help assess patient prognosis.

Key words： Carcinoma, Renal Cell/PA S100A12 Protein

收稿日期: 2023-12-20

中图分类号:

R737.11

引用本文:

宋芝峰. 肾细胞癌组织中RAGE、LOXL2蛋白的表达及其临床意义[J]. 医学临床研究, 2024, 41(9): 1301-1304.
SONG Zhifeng. Expression and Clinical Significance of RAGE and LOXL2 Proteins in Renal Cell Carcinoma. JOURNAL OF CLINICAL RESEARCH, 2024, 41(9): 1301-1304.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2024.09.006 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2024/V41/I9/1301

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