Correlation of Serum miR-28-3p and miR-23a Levels with Prognosis of Patients with Non-Small Cell Lung Cancer Treated with Radiofrequency Ablation
FENG Yanliang, LI Ye, LI Hao
Department of Oncology and Hematology, 989th Hospital of the Joint Logistic Support Force of the Chinese People's Liberation Army, Pingdingshan Henan 467000
Abstract：【Objective】 To investigate the correlation between the expression levels of serum miR-28-3p and miR-23a and the prognosis of patients with non-small cell lung cancer(NSCLC) undergoing radiofrequency ablation(RFA) treatment.【Methods】A total of 94 NSCLC patients treated with RFA were included in the study. Based on the survival status of the patients during follow-up, they were divided into a survival group(74 cases) and a deceased group(20 cases). The serum levels of miR-28-3p and miR-23a were compared between the two groups. Spearman correlation was used to assess the relationship between serum miR-28-3p and miR-23a levels and the prognosis of the patients. Receiver operating characteristic(ROC) curves were constructed to analyze the predictive value of combined detection of serum miR-28-3p and miR-23a levels for patient prognosis.【Results】 The serum levels of miR-28-3p and miR-23a in the survival group were lower than those in the deceased group(P<0.05). Spearman analysis showed that serum miR-28-3p and miR-23a levels were positively correlated with poor prognosis in NSCLC patients(P<0.05). ROC analysis indicated that the combined detection of serum miR-28-3p and miR-23a levels had a sensitivity of 95.0% and a specificity of 97.3% for predicting patient prognosis, with an area under the curve(AUC) of 0.986, which was superior to the detection of each marker alone(P<0.05).【Conclusion】 The levels of serum miR-28-3p and miR-23a are positively correlated with poor prognosis in NSCLC patients treated with RFA. Combined detection of these two markers has high sensitivity and specificity for predicting patient prognosis.
冯艳亮, 李业, 李浩. 血清miR-28-3p、miR-23a表达水平与非小细胞肺癌射频消融治疗患者预后的相关性[J]. 医学临床研究, 2024, 41(6): 831-833.
FENG Yanliang, LI Ye, LI Hao. Correlation of Serum miR-28-3p and miR-23a Levels with Prognosis of Patients with Non-Small Cell Lung Cancer Treated with Radiofrequency Ablation. JOURNAL OF CLINICAL RESEARCH, 2024, 41(6): 831-833.
2024, Vol. 41 
