血清miR-28-3p、miR-23a表达水平与非小细胞肺癌射频消融治疗患者预后的相关性

doi:10.3969/j.issn.1671-7171.2024.06.009

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摘要【目的】探讨血清miR-28-3p和miR-23a表达水平与非小细胞肺癌(NSCLC)患者接受射频消融(RFA)治疗预后的相关性。【方法】94例采用RFA治疗的NSCLC患者,根据随访患者的生存状况,分为存活组(74例)和死亡组(20例),比较两组患者的血清miR-28-3p、miR-23a水平,采用Spearman相关性分析血清miR-28-3p、miR-23a水平与患者预后的相关性,并构建受试者工作特征(ROC)曲线分析血清miR-28-3p、miR-23a水平联合检测对患者预后的预测价值。【结果】存活组患者的血清miR-28-3p、miR-23a水平均低于死亡组(P<0.05);Spearman分析结果显示,血清miR-28-3p、miR-23a水平与NSCLC患者不良预后呈正相关(P<0.05);ROC曲线分析结果显示,血清miR-28-3p、miR-23a水平联合检测对患者预后的预测灵敏度、特异度分别为95.0%、97.3%,曲线下面积(AUC)为0.986,均优于两者单独检测(P<0.05)。【结论】血清miR-28-3p和miR-23a水平与采用RFA治疗的NSCLC患者的不良预后呈正相关,两者联合检测预测患者的预后具有高灵敏度和特异度。

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	冯艳亮
	李业
	李浩

关键词 ：癌, 非小细胞肺, 微RNAs/血液, 射频消融术, 预后

Abstract：【Objective】 To investigate the correlation between the expression levels of serum miR-28-3p and miR-23a and the prognosis of patients with non-small cell lung cancer(NSCLC) undergoing radiofrequency ablation(RFA) treatment.【Methods】A total of 94 NSCLC patients treated with RFA were included in the study. Based on the survival status of the patients during follow-up, they were divided into a survival group(74 cases) and a deceased group(20 cases). The serum levels of miR-28-3p and miR-23a were compared between the two groups. Spearman correlation was used to assess the relationship between serum miR-28-3p and miR-23a levels and the prognosis of the patients. Receiver operating characteristic(ROC) curves were constructed to analyze the predictive value of combined detection of serum miR-28-3p and miR-23a levels for patient prognosis.【Results】 The serum levels of miR-28-3p and miR-23a in the survival group were lower than those in the deceased group(P<0.05). Spearman analysis showed that serum miR-28-3p and miR-23a levels were positively correlated with poor prognosis in NSCLC patients(P<0.05). ROC analysis indicated that the combined detection of serum miR-28-3p and miR-23a levels had a sensitivity of 95.0% and a specificity of 97.3% for predicting patient prognosis, with an area under the curve(AUC) of 0.986, which was superior to the detection of each marker alone(P<0.05).【Conclusion】 The levels of serum miR-28-3p and miR-23a are positively correlated with poor prognosis in NSCLC patients treated with RFA. Combined detection of these two markers has high sensitivity and specificity for predicting patient prognosis.

Key words： Carcinoma, Non-Small-Cell Lung MicroRNAs/BL Radiofrequency Ablation Prognosis

收稿日期: 2024-02-10

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R734.2

引用本文:

冯艳亮, 李业, 李浩. 血清miR-28-3p、miR-23a表达水平与非小细胞肺癌射频消融治疗患者预后的相关性[J]. 医学临床研究, 2024, 41(6): 831-833.
FENG Yanliang, LI Ye, LI Hao. Correlation of Serum miR-28-3p and miR-23a Levels with Prognosis of Patients with Non-Small Cell Lung Cancer Treated with Radiofrequency Ablation. JOURNAL OF CLINICAL RESEARCH, 2024, 41(6): 831-833.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2024.06.009 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2024/V41/I6/831