The Application Value of Fecal Occult Blood Test, Serum Carcinoembryonic Antigen and Fecal SDC2 Gene Methylation Detection in Early Colorectal Cancer screening
HE Wan, YANG Lili, REN Cun, et al
Department of Health Management, Dongguan Binhai Bay Central Hospital, Dongguan Guangdong 523900
Abstract：【Objective】To explore the application value of fecal occult blood test, serum carcinoembryonic antigen, and fecal SDC2 gene methylation detection in early screening of colorectal cancer (CRC). 【Methods】A total of 1936 individuals who underwent health examinations in our hospital from October 2019 to November 2023 were selected as the research subjects. They were randomly divided into a serum carcinoembryonic antigen detection group (n=624), a fecal occult blood test detection group (n=655), and a fecal SDC2 detection group (n=657) using a random number table method. If any of the test results are positive, it is recommended that the patient undergo electronic colonoscopy examination, and the screening results will be judged based on the gold standard of colonoscopy and pathological results. The screening value of serum carcinoembryonic antigen, fecal occult blood test, and fecal SDC2 gene methylation detection technology for CRC was evaluated separately. 【Results】Among the 1936 study subjects, 166 cases (8.57%) were initially screened positive, including 49 cases (7.85%) in the serum carcinoembryonic antigen detection group, 60 cases (9.16%) in the fecal occult blood test group, and 57 cases (8.68%) in the fecal SDC2 detection group. The positive predictive value of serum carcinoembryonic antigen detection for intestinal lesions increases with age, and the difference is statistically significant (P=0.033). There was no statistically significant difference (P>0.05) in the positive predictive values of fecal occult blood tests for detecting intestinal lesions, CRC positive predictive values, and CRC and precancerous lesions among individuals of different ages and genders. The positive predictive values of fecal SDC2 detection for CRC, CRC, and precancerous lesions increased with age, and the differences were statistically significant (P=0.014, 0.038). 【Conclusion】Fecal SDC2 gene methylation detection has a higher detection rate and CRC detection rate for all intestinal lesions than fecal occult blood test and serum carcinoembryonic antigen detection. Fecal SDC2 gene methylation detection combined with colonoscopy detection can be the preferred strategy to improve the detection rate of intestinal lesions and early CRC screening.
何琬, 杨丽莉, 任村, 唐亮. 粪便隐血试验、血清癌胚抗原与粪便SDC2基因甲基化检测在早期结直肠癌筛查中的应用价值[J]. 医学临床研究, 2024, 41(2): 203-206.
HE Wan, YANG Lili, REN Cun, et al. The Application Value of Fecal Occult Blood Test, Serum Carcinoembryonic Antigen and Fecal SDC2 Gene Methylation Detection in Early Colorectal Cancer screening. JOURNAL OF CLINICAL RESEARCH, 2024, 41(2): 203-206.
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2024, Vol. 41 
