医学临床研究
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医学临床研究  2024, Vol. 41 Issue (10): 1561-1563    DOI: 10.3969/j.issn.1671-7171.2024.10.030
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当归茯苓汤加味联合盐酸吗啡缓释片治疗原发性肝癌中重度疼痛的临床疗效
李芳, 乔普荣
湖北中医药大学附属公安中医医院,湖北 荆州 434300
Clinical Effect of Danggui Fuling Jiawei Decoction Combined with Morphine Hydrochloride Sustained-release Tablets on Moderate and Severe Pain of Primary Liver Cancer
LI Fang, QIAO Purong
Gong'an Hospital of Traditional Chinese Medicine Affiliated to Hubei University of Chinese Medicine,Jingzhou Hubei 434300
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摘要 【目的】探讨当归茯苓汤加味联合盐酸吗啡缓释片治疗原发性肝癌中重度疼痛患者的临床疗效。【方法】选择2021年6月至2023年6月本院收治的60例原发性肝癌中重度疼痛患者,采用随机数字表法将其分为观察组(给予当归茯苓汤加味联合盐酸吗啡缓释片治疗)和对照组(给予盐酸吗啡缓释片止痛治疗),每组30例。比较两组治疗后的镇痛有效率、疼痛数字评估量表(NRS)评分、血浆D-二聚体水平、不良反应发生率及舒适度情况。【结果】治疗后,两组患者NRS评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗第14天,两组患者GCQ评分均高于治疗第4天,且观察组高于对照组,差异有统计学意义(P<0.05)。观察组镇痛有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,两组血浆D-二聚体水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。【结论】当归茯苓汤加味联合盐酸吗啡缓释片治疗原发性肝癌中重度疼痛临床疗效较好,可以改善患者的高凝状态,减轻吗啡相关副反应,值得临床推广应用。
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李芳
乔普荣
关键词 肝肿瘤/中西医结合疗法癌性疼痛/中西医结合疗法治疗结果    
Abstract:【Objective】To investigate the clinical effect of Danggui Fuling Jiawei Decoction combined with morphine hydrochloride sustained-release tablets in the treatment of moderate and severe pain of primary liver cancer. 【Methods】A total of 60 patients with moderate and severe pain of primary liver cancer treated in our hospital from June 2021 to June 2023 were selected and divided into the observation group (treated with Danggui Fuling Jiawei Decoction combined with morphine hydrochloride sustained-release tablets) and the control group (treated with morphine hydrochloride sustained-release tablets for pain) by random number table method, with 30 cases in each group. The analgesic efficiency, numerical Pain Assessment Scale (NRS) score, plasma D-dimer level, incidence of adverse reactions and comfort level were compared between the two groups after treatment.【Results】After treatment, NRS scores in the two groups were lower than before treatment, and the observation group was lower than the control group, the difference was statistically significant (P<0.05). On the 14th day of treatment, the GCQ score in both groups was higher than that on the 4th day, and the observation group was higher than the control group, the difference was statistically significant (P<0.05). The effective rate of analgesia in the observation group was higher than that in the control group, the difference was statistically significant (P<0.05). After treatment, plasma D-dimer level in 2 groups was lower than before treatment, and the observation group was lower than the control group, the difference was statistically significant (P<0.05). The incidence of adverse reactions in observation group was lower than that in control group, and the difference was statistically significant (P<0.05). 【Conclusion】Danggui Fuling Jiawei Decoction combined with morphine hydrochloride sustained release tablets has good clinical efficacy in the treatment of moderate and severe pain of primary liver cancer, which can improve the hypercoagulable state of patients and alleviate morphine related side effects, and is worthy of clinical application.
Key wordsLiver Neoplasms/ZJ    Cancer Pain/ZJ    Treatment Outcome
收稿日期: 2023-09-22     
中图分类号:  R735.7  
引用本文:   
李芳, 乔普荣. 当归茯苓汤加味联合盐酸吗啡缓释片治疗原发性肝癌中重度疼痛的临床疗效[J]. 医学临床研究, 2024, 41(10): 1561-1563.
LI Fang, QIAO Purong. Clinical Effect of Danggui Fuling Jiawei Decoction Combined with Morphine Hydrochloride Sustained-release Tablets on Moderate and Severe Pain of Primary Liver Cancer. JOURNAL OF CLINICAL RESEARCH, 2024, 41(10): 1561-1563.
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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2024.10.030     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2024/V41/I10/1561
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