Abstract：【Objective】 To investigate the clinical efficacy and survival outcomes of tislelizumab combined with sunitinib in the treatment of metastatic renal cancer.【Methods】 Forty-two patients with metastatic renal cancer were randomly divided into the observation group and the control group, with 21 patients in each group. The observation group was treated with oral sunitinib combined with intravenous tislelizumab, while the control group was treated with oral sunitinib combined with intravenous saline. After six treatment cycles, the efficacy, incidence of adverse reactions, and survival prognosis were compared between the two groups. Additionally, CD3+, CD4+, CD4+/CD8+, matrix metalloproteinase-2 (MMP-2), vascular endothelial growth factor (VEGF), and tissue inhibitor of metalloproteinases-1 (TIMP-1) levels were measured before and after treatment and compared between the two groups.【Results】 The disease control rate in the observation group was 90.48%, which was significantly higher than that of 61.90% in the control group (P<0.05). After treatment, CD3+, CD4+, and CD4+/CD8+ levels increased in both groups, with the observation group showing higher levels than the control group (P<0.05). MMP-2, VEGF, and TIMP-1 levels decreased in both groups post-treatment, with lower levels in the observation group compared to the control group (P<0.05). The incidence of adverse reactions between the two groups showed no statistically significant difference (P>0.05). The median progression-free survival (PFS) was 11 months in the control group and 15 months in the observation group, with a statistically significant difference between the PFS curves of the two groups (P<0.05).【Conclusion】 Tislelizumab combined with sunitinib is effective and safe in the treatment of metastatic renal cancer.
王梦婕, 郭小芳. 替雷利珠单抗联合舒尼替尼治疗转移性肾癌的临床疗效及生存分析[J]. 医学临床研究, 2024, 41(10): 1526-1529.
WANG Mengjie, GUO Xiaofang. Clinical Efficacy and Survival Analysis of Tislelizumab Combined with Sunitinib in the Treatment of Metastatic Renal Cancer. JOURNAL OF CLINICAL RESEARCH, 2024, 41(10): 1526-1529.
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2024, Vol. 41 
