医学临床研究
  2025年4月6日 星期日           首 页    |    期刊简介    |    编委会    |    投稿指南    |    期刊订阅    |    广告合作    |    留言板    |    联系我们    |    English
医学临床研究  2024, Vol. 41 Issue (7): 991-993    DOI: 10.3969/j.issn.1671-7171.2024.07.009
  论著 本期目录 | 过刊浏览 | 高级检索 |
血小板分布宽度预测肺腺癌根治性切除术患者预后的临床价值
徐素梅1, 朱荣荣2*
1.上海国际医学中心检验科,上海 201321;
2.海军军医大学第一附属医院检验科,上海 200434
Clinical Value of Platelet Distribution Width in Predicting the Prognosis of Patients with Radical Resection of Lung Adenocarcinoma
XU Sumei, ZHU Rongrong
Department of Laboratory Medicine, Shanghai International Medical Center, Shanghai 201321
全文: PDF (1273 KB)   HTML (1 KB) 
输出: BibTeX | EndNote (RIS)      
摘要 【目的】探讨血小板分布宽度(PDW)预测肺腺癌根治性切除术患者预后的临床价值。【方法】测定两院收治的186例行肺腺癌根治切除术治疗的患者的PDW,根据受试者工作特征(ROC)曲线确定PDW临界值,将患者分为高PDW组与低PDW组。分析PDW与肺腺癌患者临床特征的关系。出院后连续随访3年,采用多因素Cox回归分析肺腺癌患者预后的影响因素。【结果】PDW最佳截断值为2.57时预测价值最高。 TNM分期为Ⅱ~Ⅲ期、肿瘤直径>3 cm患者的PDW高表达率高于TNM分期为Ⅰ期、肿瘤直径≤3 cm的患者(P<0.05)。随访3年,186例患者中119例存活,总生存率为63.98%(119/186);患者3年总生存率与TNM分期、肿瘤直径、PDW有关(均P<0.05);低PDW组患者的3年总生存率为79.00%(79/100),高于高PDW组的46.51%(40/86)(P<0.05)。多因素Cox回归分析显示:TNM分期为Ⅱ~Ⅲ期、肿瘤直径≥3 cm、PDW≥2.57是患者预后不良的危险因素(P<0.05)。【结论】PDW与肺腺癌根治性切除术患者预后密切相关,其对患者预后的评估具有较高的预测价值,PDW、TNM分期、肿瘤直径均为影响肺腺癌患者预后的独立危险因素。
服务
把本文推荐给朋友
加入我的书架
加入引用管理器
E-mail Alert
RSS
作者相关文章
徐素梅
朱荣荣
关键词 肺肿瘤/外科学腺癌/外科学血小板预后    
Abstract:【Objective】 To explore the clinical value of platelet distribution width (PDW) in predicting the prognosis of patients with radical resection of lung adenocarcinoma. 【Methods】The PDW levels of 186 patients undergoing radical resection of lung adenocarcinoma admitted to two hospitals were measured. The critical value of PDW was determined based on the receiver operating characteristic (ROC) curve of the subjects, and the patients were divided into high PDW group and low PDW group. The relationship between PDW levels and clinical characteristics of cancer patients was analyzed. After discharge, continuous follow-up for 3 years was conducted to explore the influencing factors of patient prognosis using multivariate Cox regression analysis. 【Results】The optimal cutoff value for PDW was 2.57, which had the highest predictive value. The high expression rate of PDW in patients with TNM stage Ⅱ-Ⅲ and tumor diameter>3 cm was higher than that in patients with TNM stage I and tumor diameter ≤ 3 cm (P<0.05). After a 3-year follow-up, 119 out of 186 patients survived, with an overall survival rate of 63.98% (119/186); The 3-year overall survival rate of patients was related to TNM staging, tumor diameter, and PDW (mean P<0.05); The 3-year overall survival rate of patients in the low PDW group was 79.00% (79/100), which was higher than the 46.51% (40/86) in the high PDW group (P<0.05). Multivariate Cox regression analysis showed that TNM stage Ⅱ-Ⅲ, tumor diameter ≥3 cm, and PDW ≥ 2.57 were risk factors for poor prognosis in patients (P<0.05). 【Conclusion】The level of PDW is closely related to the prognosis of patients with radical resection of lung adenocarcinoma, and it also has high predictive value for prognosis evaluation. PDW, TNM staging, and tumor diameter are independent risk factors affecting patient prognosis.
Key wordsLung Neoplasms/SU    Adenocarcinoma/SU    Blood Platelets    Prognosis
收稿日期: 2024-02-20     
中图分类号:  R734.2  
通讯作者: * E-mail:865676533@qq.com   
引用本文:   
徐素梅, 朱荣荣. 血小板分布宽度预测肺腺癌根治性切除术患者预后的临床价值[J]. 医学临床研究, 2024, 41(7): 991-993.
XU Sumei, ZHU Rongrong. Clinical Value of Platelet Distribution Width in Predicting the Prognosis of Patients with Radical Resection of Lung Adenocarcinoma. JOURNAL OF CLINICAL RESEARCH, 2024, 41(7): 991-993.
链接本文:  
http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2024.07.009     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2024/V41/I7/991
版权所有 © 2013 医学临床研究杂志社  湘ICP备13012052号-1
办公地址:湖南省长沙市芙蓉区新军路43号煤炭大院主办公楼6楼621、623、632、636室 邮编:410011 电话(传真):0731-84824007 E-mail:jcr_cs.hn@vip.163.com
技术支持:北京玛格泰克科技发展有限公司 技术支持:support@magtech.com.cn