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医学临床研究  2023, Vol. 40 Issue (4): 589-591    DOI: 10.3969/j.issn.1671-7171.2023.04.030
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血清免疫球蛋白、C3、C4水平变化与高血压脑出血患者预后的相关性分析
陈红男, 奚凤瑜, 张赟, 赵海*
陕西省人民医院,陕西 西安 710068
Correlation Analysis of Serum Immunoglobulin,C3 and C4 Levels with Prognosis of Patients with Hypertensive Intracerebral Hemorrhage
CHEN Hong-nan, XI Feng-yu, ZHANG Yun, et al
Shaanxi Provincial People's Hospital,Xi'an Shaanxi 710068
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摘要 【目的】探讨血清免疫球蛋白、C3、C4水平变化与高血压脑出血(HICH)患者预后的相关性。【方法】选取2018年1月至2021年5月本院收治的114例HICH患者(观察组),并选择同期67例血压控制良好的高血压患者(对照组)。比较对照组入院当天及观察组术前、术后血清免疫球蛋白(IgG、IgA)、C3、C4水平。根据观察组预后情况将其分为预后良好组和预后不良组,比较不同预后患者术后7 d血清免疫球蛋白、C3、C4水平。采用Spearman秩相关模型及COX逐步回归模型分析血清免疫球蛋白、C3、C4水平与患者预后的相关性。【结果】观察组术后1 d、3 d、7 d、14 d血清IgG、IgA水平及术前C3、C4水平低于对照组(P<0.05);观察组术前至术后7 d血清IgG、IgA水平呈降低趋势,C3、C4水平呈升高趋势,差异有统计学意义(P<0.05)。预后良好组患者血清IgG、IgA水平高于预后不良组患者,C3、C4水平低于预后不良患者(P<0.05)。Spearman秩相关分析显示,术后7 d血清IgG、IgA水平与预后呈正相关,C3、C4水平与预后呈负相关。COX逐步回归模型分析显示,术后7 d血清IgG、IgA、C3、C4水平为影响HICH患者预后的相关因素(P<0.05)。【结论】血清免疫球蛋白、C3、C4水平变化与HICH患者预后密切相关,动态监测其水平变化便于指导临床完善治疗方案。
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陈红男
奚凤瑜
张赟
赵海
关键词 颅内出血,高血压性免疫球蛋白A免疫球蛋白G补体C3补体C4预后    
Abstract:【Objective】 To investigate the relationship of serum immunoglobulin,C3 and C4 levels with the prognosis of patients with hypertensive intracerebral hemorrhage (HICH). 【Methods】 A total of 114 patients with HICH in our hospital from January 2018 to May 2021 were selected as the control group. In the same period,67 hypertensive patients with good blood pressure were enrolled in the control group. The levels of serum immunoglobulin (IgG,IgA),C3,and C4 were compared between the control group on the day of admission and the observation group before operation and after operation. According to the prognosis of the observation group,patients were divided into the good prognosis group and the poor prognosis group. The levels of serum immunoglobulin,C3,and C4 in patients with different prognosis were compared 7 days after operation. Spearman rank correlation model and COX stepwise regression model were used to analyze the correlation between levels of serum immunoglobulin,C3,C4 with the prognosis of patients. 【Results】 Serum IgG,IgA levels and preoperative C3,C4 levels in the observation group were lower than those in the control group on 1 day,3 days,7 days,and 14 days after operation (P<0.05); The level of C3 and C4 showed a decreasing trend,and the levels of C3 and C4 showed a rising trend,and the difference was statistically significant (P<0.05). The serum IgG and IgA levels of patients in the good prognosis group were higher than those of patients in the poor prognosis group,while the levels of C3 and C4 in the good prognosis group were lower than those of patients in the poor prognosis group (P<0.05). Spearman rank correlation analysis showed that serum IgG and IgA levels 7 days after surgery were positively correlated with prognosis,and C3 and C4 levels were negatively correlated with prognosis. COX stepwise regression model analysis showed that serum IgG,IgA,C3,and C4 levels 7 days after operation were the relevant factors affecting prognosis (P<0.05).【Conclusion】 The levels of serum immunoglobulin,C3 and C4 are significantly correlated with the prognosis of patients with HICH. Dynamic monitoring of the changes of serum immunoglobulin,C3 and C4 levels is helpful to guide the clinical treatment.
Key wordsIntracranial Hemorrhage,Hypertensive    Immunoglobulin A/BL    Immunoglobulin G/BL    Complement C3    Complement C4    Prognosis
收稿日期: 2022-04-11     
中图分类号:  R743.2  
通讯作者: * E-mail:sunsea1985@126.com   
引用本文:   
陈红男, 奚凤瑜, 张赟, 赵海. 血清免疫球蛋白、C3、C4水平变化与高血压脑出血患者预后的相关性分析[J]. 医学临床研究, 2023, 40(4): 589-591.
CHEN Hong-nan, XI Feng-yu, ZHANG Yun, et al. Correlation Analysis of Serum Immunoglobulin,C3 and C4 Levels with Prognosis of Patients with Hypertensive Intracerebral Hemorrhage. JOURNAL OF CLINICAL RESEARCH, 2023, 40(4): 589-591.
链接本文:  
http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2023.04.030     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2023/V40/I4/589
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