Value of hs-TnI Level combined with Clinical Characteristics in Predicting Short-term Prognosis of Elderly Patients with Acute Ischemic Cerebral Infarction
CHANG Rong, ZHANG Jin-qiao, GAO Pan, et al
Department of Neurology,Xi'an Dianli Hospital,Shaanxi Xi'an 710032
Abstract：【Objective】 To investigate the value of high-sensitivity troponin I ( hs-TnI) level combined with clinical characteristics in predicting the short-term prognosis of elderly patients with acute ischemic cerebral infarction. 【Methods】 The clinical data of 124 elderly patients with acute ischemic cerebral infarction were analyzed retrospectively. They were divided into the poor prognosis group (n=40) and the good prognosis group(n=84). The information of clinical data [gender,age,body mass index (BMI),smoking,drinking,hypertension,blood glucose,sleep apnea syndrome,swallowing and choking cough,atrial fibrillation,pulmonary infection],hs-TnI,NIHSS score and large area infarction level were collected. The differential information between the two groups was incorporated into the logistic model for analysis. The prognosis was taken as the dependent variable and blood glucose,sleep apnea syndrome(SAS),atrial fibrillation,pulmonary infection,hs-TnI level,NIHSS score were taken as independent variables to clarify the risk factors affecting the short-term prognosis of elderly patients with acute ischemic cerebral infarction. 【Results】 There were no significant differences in terms of gender,age,BMI,smoking,drinking,hypertension,swallowing and choking cough between the two groups (P>0.05).The proportion of blood glucose >6.1 mmol/L,SAS,atrial fibrillation,pulmonary infection in the poor prognosis group was significantly higher than that in the good prognosis group (P<0.05).The hs-TnI and NIHSS score levels in the poor prognosis group were significantly higher than those in the good prognosis group (P<0.05).The area under the poor prognosis curve (AUC) predicted by hs-TnI was 0.719,the best boundary value was 19.32 ng/mL,the sensitivity was 70.00%,and the specificity was 56.70%. Multivariate logistic regression analysis confirmed that blood glucose ≥6.10 mmol/L,SAS,atrial fibrillation,pulmonary infection,hs-TnI ≥ 19.32 ng/mL,NIHSS score ≥ 15.25 were the risk factors for poor prognosis in elderly patients with acute ischemic cerebral infarction (P<0.05).The AUC of hs-TnI combined with the poor clinical features was 0.983,with a sensitivity of 95.00% and a specificity of 92.90%.【Conclusion】 The short-term prognosis of elderly patients with acute ischemic cerebral infarction is affected by blood glucose,SAS,atrial fibrillation,pulmonary infection,hs-TnI level,NIHSS score. Clinicians should pay close attention to them and make proper intervention in time.
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2023, Vol. 40 
