三磷酸腺苷结合盒家族G2基因多态性与创伤性脑损伤患者预后的相关性

doi:10.3969/j.issn.1671-7171.2023.03.017

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摘要【目的】探讨三磷酸腺苷结合盒家族G2(ABCG2)基因多态性与创伤性脑损伤(TBI)患者预后的相关性。【方法】选取2018年1月至2020年5月西安医学高等专科学校附属医院收治的123例TBI患者,根据预后情况将患者分为预后良好组(预后良好,n=99)和预后不良组(预后不良,n=24)。分析ABCG2基因多态性位点不同的等位基因与TBI患者预后的关系,分析影响TBI患者预后的因素。【结果】123例TBI患者中24例(19.51%)发生预后不良,其余99例(80.49%)预后良好。单因素分析显示,两组患者在年龄、入院时格拉斯哥昏迷评分(GCS评分)、合并脑挫伤、合并蛛网膜下腔出血、合并胸腹部损伤方面比较,差异有统计学意义(P<0.05)。预后不良组中rs2032582基因G位点所占比例高于预后良好组(P<0.05)。Logistic回归分析显示,入院时GCS评分、rs2032582等位基因、年龄、合并脑挫伤、合并胸腹部损伤、合并蛛网膜下腔出血是影响TBI患者预后的独立影响因素(P<0.05)。【结论】ABCG2基因多态性与TBI患者预后相关,入院时GCS评分、rs2032582等位基因、年龄、合并脑挫伤、合并胸腹部损伤、合并蛛网膜下腔出血是影响TBI患者预后的独立影响因素。

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	席涛
	王海
	赵金龙

关键词 ：脑损伤,创伤性, ATP结合盒转运体,亚家族G,成员2/遗传学, 多态现象,遗传, 预后

Abstract：【Objective】 To investigate the correlation between adenosine triphosphate binding cassette family G2 (ABCG2) gene polymorphism and prognosis in patients with traumatic brain injury (TBI). 【Methods】 A total of 123 TBI patients admitted to the Affiliated Hospital of Xi'an Medical College from January 2018 to May 2020 were selected and divided into an observation group (good prognosis,n=99) and a control group (poor prognosis,n=24) based on the prognosis. The relationship between the different alleles of ABCG2 gene polymorphism and the prognosis of TBI patients was analyzed,and the factors affecting the prognosis of TBI patients were analyzed. 【Results】 Of the 123 patients with TBI,24 cases(19.51%) had a poor prognosis,while the remaining 99 cases(80.49%) had a good prognosis. Univariate analysis showed that there was a statistically significant difference between the two groups in terms of age,Glasgow Coma Score (GCS) at admission,brain contusion,subarachnoid hemorrhage,and chest and abdominal injury (P<0.05). The proportion of the G locus of rs2032582 gene in the group with poor prognosis was higher than that in the group with good prognosis (P<0.05). Logistic regression analysis showed that GCS score at admission,rs2032582 allele,age,combined with brain contusion,combined with chest and abdominal injury,and combined with subarachnoid hemorrhage were independent factors affecting the prognosis of TBI patients (P<0.05). 【Conclusion】 ABCG2 gene polymorphism is associated with the prognosis of TBI patients. GCS score at admission,rs2032582 allele,age,brain contusion,chest and abdominal injury,and subarachnoid hemorrhage are independent factors that affect the prognosis of TBI patients.

Key words： Brain Injuries,Traumatic ATP Binding Cassette Transporter,Subfamily G,Member 2/GE Polymorphism,Genetic Prognosis

收稿日期: 2022-04-24

中图分类号:

R651.15

通讯作者: * E-mail:zhao_jin_long@163.com

引用本文:

席涛, 王海, 赵金龙. 三磷酸腺苷结合盒家族G2基因多态性与创伤性脑损伤患者预后的相关性[J]. 医学临床研究, 2023, 40(3): 381-384.
XI Tao, WANG Hai, ZHAO Jin-long. Association Study of G2 Gene Polymorphism of Adenosine Triphosphate Binding Cassette Family and Prognosis of Patients with Traumatic Brain Injury. JOURNAL OF CLINICAL RESEARCH, 2023, 40(3): 381-384.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2023.03.017 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2023/V40/I3/381