Abstract：【Objective】To investigate the expression and clinical significance of microRNA-1181 (miR-1181) in nasopharyngeal carcinoma (NPC). 【Methods】 A total of 71 NPC patients who received surgical treatment in the Ankang Central Hospital from October 2019 to May 2021 were randomly recruited. The relative expression of miR-1181 in NPC tissues and normal tissues adjacent to cancer was detected by real-time fluorescent quantitative PCR (RT-PCR),and the relative expression of miR-1181 in NPC tissues of patients with different degrees of differentiation,clinical stages,and distant metastasis was compared. All patients were followed up to analyze the correlation between miR-1181 and the prognosis of NPC. 【Results】Compared with normal tissues adjacent to cancer,miR-1181 was significantly down-regulated in NPC tissues; The relative expression of miR-1181 in clinical stage Ⅲ+Ⅳ NPC tissues was lower than that in stage Ⅰ+Ⅱ NPC tissues,the relative expression of miR-1181 in moderately and poorly differentiated NPC tissues was lower than that in highly differentiated NPC tissues,and the relative expression of miR-1181 in NPC tissues with distant metastasis was lower than that in non-metastatic NPC tissues,the difference was statistically significant (P<0.05). The relative expression of miR-1181 in patients with good prognosis was significantly higher than that in patients with poor prognosis (P<0.05); Logistic regression analysis showed that miR-1181<3.59 was associated with poor prognosis of NPC,and its odds ratio (OR)(95%CI) was 3.52 (1.65~5.28). 【Conclusion】 miR-1181 is low expression in NPC tissues,and high expression in NPC tissues with high differentiation,low clinical stage and distant metastasis,and miR-1181<3.59 is a risk factor for poor prognosis of NPC patients.
罗振峰, 杨航, 李恒. miR-1181在鼻咽癌组织中的表达及其临床意义[J]. 医学临床研究, 2023, 40(2): 220-222.
LUO Zhen-feng, YANG Hang, LI Heng. Expression of miR-1181 in Nasopharyngeal Carcinoma and its Clinical Significance. JOURNAL OF CLINICAL RESEARCH, 2023, 40(2): 220-222.
2023, Vol. 40 
