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医学临床研究  2022, Vol. 39 Issue (6): 831-834    DOI: 10.3969/j.issn.1671-7171.2022.06.009
  论著 本期目录 | 过刊浏览 | 高级检索 |
循环外泌体miR-151-5p对早期胃癌的诊断价值
闫润生1, 刘慧霞2**
1.中国人民解放军联勤保障部队第九八七医院急诊科,陕西 宝鸡 721004;
2.西安高新医院全科医疗科,陕西 西安 710061
Diagnostic Value of Circulating Exosome miR-151-5p in Early Gastric Cancer
YAN Run-sheng, LIU Hui-xia
The 987th Hospital of Chinese People Liberation Army Joint Logistics Support Force,Baoji Shaanxi 721004
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摘要 【目的】探讨循环外泌体微小RNA-151-5p(miR-151-5p)在早期胃癌患者血清中的表达水平及诊断价值。【方法】选取40例早期胃癌患者、43例住院治疗的胃良性疾病患者及在肠胃门诊行常规检查的健康者分别作为胃癌组、良性组及对照组。采用实时荧光定量PCR法(qRT-PCR)检测血清循环外泌体miR-151-5p表达水平,分析其与早期胃癌临床病理特征的关系,通过研究对象工作特征曲线(ROC曲线)评估其对早期胃癌的诊断价值。【结果】胃癌组和良性组血清循环外泌体miR-151-5p表达水平高于对照组,且胃癌组高于良性组(P<0.001)。循环外泌体miR-151-5p表达与早期胃癌病理类型及分化程度相关(P<0.05)。循环外泌体miR-151-5p诊断早期胃癌的曲线下面积为0.808,当最佳截断值为1.848时,敏感度和特异性分别为90.0%、57.4%。【结论】循环外泌体miR-151-5p在早期胃癌患者血清中表达明显升高,对早期胃癌的诊断及病情评估有一定潜在价值。
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闫润生
刘慧霞
关键词 胃肿瘤/诊断外泌体微RNAs    
Abstract:【Objective】To investigate the expression of circulating exosome microrna-151-5p (miR-151-5p) in serum of patients with early gastric cancer and its diagnostic value.【Methods】A total of 40 patients with early gastric cancer,43 hospitalized patients with benign gastric diseases and healthy persons undergoing routine examination in the gastrointestinal outpatient department were selected as the gastric cancer group,benign group and control group respectively. The expression level of miR-151-5p in serum circulating exosomes was detected by real-time fluorescence quantitative PCR (qRT-PCR),and the relationship between miR-151-5p and clinicopathological features of early gastric cancer was analyzed. The diagnostic value of miR-151-5p in early gastric cancer was evaluated by object operating characteristic curve (ROC). 【Results】The expression of miR-151-5p in serum of the gastric cancer group and the benign group was higher than that of the control group,and that of the gastric cancer group was higher than that of the benign group (P<0.001). The expression of miR-151-5p in circulating exosomes was correlated with the pathological type and differentiation degree of early gastric cancer (P<0.05). The area under the curve of circulating exosome miR-151-5p for the diagnosis of early gastric cancer was 0.808. When the optimal cutoff value was 1.848,the sensitivity and specificity were 90.0% and 57.4% respectively. 【Conclusion】 The expression of miR-151-5p in the serum of patients with early gastric cancer is significantly increased,which has certain potential value in the diagnosis and evaluation of early gastric cancer.
Key wordsStomach Neoplasms/DI    Exosomes    MicroRNAs
收稿日期: 2021-12-06     
中图分类号:  R735.2  
基金资助:陕西省重点研发计划项目(2017ZDXM-SF-25-5)
通讯作者: **E-mail:1554064533@qq.com   
引用本文:   
闫润生, 刘慧霞. 循环外泌体miR-151-5p对早期胃癌的诊断价值[J]. 医学临床研究, 2022, 39(6): 831-834.
YAN Run-sheng, LIU Hui-xia. Diagnostic Value of Circulating Exosome miR-151-5p in Early Gastric Cancer. JOURNAL OF CLINICAL RESEARCH, 2022, 39(6): 831-834.
链接本文:  
http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2022.06.009     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2022/V39/I6/831
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