Abstract：【Objective】To investigate the clinical effect of venlafaxine combined with Namefene in the treatment of alcoholic mental and behavioral disorders.【Methods】A total of 72 patients with alcoholic mental and behavioral disorders admitted to Ankang Central Hospital from May 2019 to March 2020 were randomly divided into observation group and control group with 36 patients in each group. The control group was treated with routine therapy and Namefene, while the observation group was treated with venlafaxine on the basis of the control group. The therapeutic effect, adverse reaction rate, PANSS score, levels of neurocytokines [brain derived neurotrophic factor(BDNF), nerve growth factor (NGF), neurotrophin-3 (NT-3)], and the scores of Loewenstein Occupational Therapy Cognitive Assessment Scale (LOTCA) and Montreal Cognitive Assessment Scale (MoCA) before and after treatment were compared between the two groups. 【Results】 After 28 days of treatment, the total effective rate in the observation group was 94.44% (34/36), higher than that in the control group [77.78% (28/36)], with a statistically significant difference(χ2=4.18,P=0.04);The positive symptom score, negative symptom score, general psychopathology score and total score of the two groups were lower than those before treatment, and the observation group was lower than the control group, with a statistically significant difference (P<0.05); The levels of serum BDNF, NGF and NT-3 in the two groups were higher than those before treatment, and those in the observation group were higher than those in the control group, with a statistically significant difference (P<0.05); The scores of LOTCA and MoCA in the two groups were higher than those before treatment, and those in the observation group were higher than those in the control group, with a statistically significant difference (P<0.05). There was no significant difference between the two groups in the incidence of nausea, vomiting, dizziness, lethargy, dry mouth, diarrhea and skin itching (P>0.05). 【Conclusion】 Venlafaxine combined with Namefene is helpful to regulate the level of neurocytokines in patients with alcoholic mental and behavioral disorders, improve clinical treatment effect, improve mental symptoms, reduce cognitive dysfunction, and has good safety.
徐娟, 李小雪. 文拉法辛联合纳美芬治疗酒精性精神和行为障碍的临床效果[J]. 医学临床研究, 2022, 39(9): 1368-1371.
XU Juan, LI Xiao-xue. Analysis of Clinical Effect of Venlafaxine Combined with Namefene in the Treatment of Alcoholic Mental and Behavioral Disorders. JOURNAL OF CLINICAL RESEARCH, 2022, 39(9): 1368-1371.
2022, Vol. 39 
