医学临床研究
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医学临床研究  2021, Vol. 38 Issue (4): 566-568    DOI: 10.3969/j.issn.1671-7171.2021.04.025
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左乙拉西坦联合地西泮治疗热惊厥患儿临床疗效研究
张淼, 王越, 张鹏, 刘阳, 朱彩华, 薛海蓉
南阳市中心医院儿一科,河南 南阳 473000
Efficacy and Mechanism of Levetiracetam Combined with Diazepam in Treatment of Children with Febrile Convulsion
ZHANG Miao, WANG Yue, ZHANG Peng, et al
Nanyang Central Hospital,Nanyang 473000
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摘要 【目的】 探讨左乙拉西坦联合地西泮治疗热惊厥患儿疗效及对血清Zeste基因增强子同源物2(EZH2)、神经元特异性烯醇化酶(NSE)、S100β、神经元特异性生长因子(BDNF)水平的影响。【方法】 选取2018年1月至2019年12月本院收治的100例热惊厥患儿(观察组),并选择同期门诊健康体检的100例儿童作为对照组,根据治疗方法的不同将观察组患儿分为A组(采用地西泮治疗)和B组(左乙拉西坦联合地西泮治疗),各50例。比较不同组别血清EZH2、NSE、S100β、BDNF水平,比较两组临床疗效及相关指标的变化。【结果】 观察组血清EZH2、NSE、S100β、BDNF水平均高于对照组,差异有统计学意义(P<0.05)。A组患儿药物起效时间、惊厥停止时间分别为(21.60±3.95)min、(24.51±4.06)min,B组分别为(17.53±3.04)min、(20.48±3.77)min,两组比较差异均有统计学意义(均P<0.05)。治疗后,B组患儿血清EZH2、NSE、S100β水平均低于对照组,差异均有统计学意义(均P<0.05)。B组患儿临床有效率为96%(48/50),高于A组患儿的92%(42/50),差异有统计学意义(Z=-2.198,P=0.028<0.05)。【结论】 热惊厥患儿血清EZH2、NSE、S100β、BDNF水平明显高于较健康儿童,左乙拉西坦联合地西泮治疗热惊厥患儿效果优于单用地西泮。
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关键词 惊厥,发热性/药物疗法吡拉西坦/药理学地西泮/药理学儿童    
Abstract【Objective】 To explore the curative effect of levetiracetam combined with diazepam in the treatment of children with febrile convulsion and the effect on serum Zeste gene enhancer homolog 2 (EZH2), neuron-specific enolase (NSE), S100β, neuron-specific growth factor (BDNF) level of influence.【Methods】 A total of 100 children with febrile convulsion admitted to our hospital from January 2018 to December 2019 were selected as the observation group, and 100 children in the same period from outpatient health examination were selected as the healthy control group. According to different treatment methods, the observation group was further divided into the group A (treated with diazepam, n=50) and the group B (treated with levetiracetam combined with diazepam, n=50).Serum EZH2, NSE, S100 β and BDNF levels were recorded and compared. 【Results】 The levels of serum EZH2, NSE, S100β and BDNF in the observation group were higher than those in the healthy control group (P<0.05). The drug onset time and seizure stopping time in the group A were (21.60±3.95) min and (24.51±4.06) min, respectively, while in the group B, they were (17.53±3.04) min and (20.48±3.77) min, respectively. The differences between the two groups were statistically significant (all P<0.05).Before treatment, the levels of serum EZH2, NSE, S100β and BDNF in both group A and B were not statistically significant (P>0.05). After treatment, the levels of serum EZH2, NSE and S100β in the group B were lower than those in the group A (P<0.05). The clinical effective rate of children in group B was 96% (48/50), which was higher than 92% (42/50) of children in group A; and the difference was statistically significant (Z=-2.198, P=0.028<0.05). 【Conclusion】 The serum EZH2, NSE, S100 β,and BDNF levels of febrile convulsion children were significantly higher than those of healthy children. The effect of levetiracetam combined with diazepam on febrile convulsion children was better than that of diazepam alone.
Key wordsSeizures, Febrile/DT    Piracetam/PD    Diazepam/PD    Child
收稿日期: 2020-10-26     
中图分类号:  R725  
引用本文:   
张淼, 王越, 张鹏, 刘阳, 朱彩华, 薛海蓉. 左乙拉西坦联合地西泮治疗热惊厥患儿临床疗效研究[J]. 医学临床研究, 2021, 38(4): 566-568.
ZHANG Miao, WANG Yue, ZHANG Peng, et al. Efficacy and Mechanism of Levetiracetam Combined with Diazepam in Treatment of Children with Febrile Convulsion. JOURNAL OF CLINICAL RESEARCH, 2021, 38(4): 566-568.
链接本文:  
http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2021.04.025     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2021/V38/I4/566
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