Abstract：【Objective】 To explore the curative effect of levetiracetam combined with diazepam in the treatment of children with febrile convulsion and the effect on serum Zeste gene enhancer homolog 2 (EZH2), neuron-specific enolase (NSE), S100β, neuron-specific growth factor (BDNF) level of influence.【Methods】 A total of 100 children with febrile convulsion admitted to our hospital from January 2018 to December 2019 were selected as the observation group, and 100 children in the same period from outpatient health examination were selected as the healthy control group. According to different treatment methods, the observation group was further divided into the group A (treated with diazepam, n=50) and the group B (treated with levetiracetam combined with diazepam, n=50).Serum EZH2, NSE, S100 β and BDNF levels were recorded and compared. 【Results】 The levels of serum EZH2, NSE, S100β and BDNF in the observation group were higher than those in the healthy control group (P<0.05). The drug onset time and seizure stopping time in the group A were (21.60±3.95) min and (24.51±4.06) min, respectively, while in the group B, they were (17.53±3.04) min and (20.48±3.77) min, respectively. The differences between the two groups were statistically significant (all P<0.05).Before treatment, the levels of serum EZH2, NSE, S100β and BDNF in both group A and B were not statistically significant (P>0.05). After treatment, the levels of serum EZH2, NSE and S100β in the group B were lower than those in the group A (P<0.05). The clinical effective rate of children in group B was 96% (48/50), which was higher than 92% (42/50) of children in group A; and the difference was statistically significant (Z=-2.198, P=0.028<0.05). 【Conclusion】 The serum EZH2, NSE, S100 β,and BDNF levels of febrile convulsion children were significantly higher than those of healthy children. The effect of levetiracetam combined with diazepam on febrile convulsion children was better than that of diazepam alone.
张淼, 王越, 张鹏, 刘阳, 朱彩华, 薛海蓉. 左乙拉西坦联合地西泮治疗热惊厥患儿临床疗效研究[J]. 医学临床研究, 2021, 38(4): 566-568.
ZHANG Miao, WANG Yue, ZHANG Peng, et al. Efficacy and Mechanism of Levetiracetam Combined with Diazepam in Treatment of Children with Febrile Convulsion. JOURNAL OF CLINICAL RESEARCH, 2021, 38(4): 566-568.
2021, Vol. 38 
