Abstract：【Objective】 To investigate the clinical characteristics and prognosis of childhood patients with drug-induced hypersensitivity syndrome(DIHS). 【Methods】 The clinical data of 9 children with DIHS were retrospectively analyzed, including allergic drugs, clinical manifestations, laboratory examination, imaging examination, treatment and prognosis.【Results】 There were 4 males and 5 females, aged from 8 months to 10 years. Allergic antibiotics accounted for 44.4%, including 2 cases of mezlocillin sulbactam, 1 case of cefathiamidine and 1 case of fosfomycin; anticonvulsant drugs accounted for 33.4%, including carbamazepine in 3 cases; antipyretic drugs accounted for 22.2%, including ibuprofen in 2 cases; the incubation period was 20 (10~40) d. Course of disease from was 21 ds to 4 months, 6 cases showed exfoliative dermatitis, 5 cases with hepatomegaly, 8 cases with abnormal transaminase, 6 cases with myocardial injury, 5 cases with pneumonia, 2 cases with Epstein Barr virus infection and 1 case with cytomegalovirus infection. Among them, 8 cases were cured after symptomatic support treatment with intravenous hormone, gamma globulin, anti infection and fluid infusion, and 2 cases had two peaks in the treatment process One patient died of multiple organ failure and suspected hemophagocytic syndrome. 【Conclusion】 Antibiotics and anticonvulsant drugs are common in children with DIHS. Exfoliative dermatitis is the main manifestation of skin rash. Liver and myocardial damage often occur. For patients with chronic viral infection, we should be alert to the phenomenon of two peaks. Patients with rapid progress of disease can be complicated with Hemophilus syndrome.
罗鸯鸯, 树叶, 汤建萍, 韦祝, 孙磊, 周斌. 儿童药物超敏反应综合征临床特点分析[J]. 医学临床研究, 2020, 37(9): 1294-1296.
LUO Yang-yang, SHU Ye, TANG Jian-ping, et al. Clinical Characteristics of Drug Hypersensitivity Syndrome in Children. JOURNAL OF CLINICAL RESEARCH, 2020, 37(9): 1294-1296.
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2020, Vol. 37 
