Comparative Study of Preoperative Systemic Intravenous Chemotherapy and Transcatheter Arterial Embolization Chemotherapy in Children with Nephroblastoma
LIU Yu, HE Jun, He Tian-qu, et al
Department of Urology, Hunan Children's Hospital,Changsha 410007, China
Abstract：【Objective】 To compare and analyze the effect of preoperative systemic venous chemotherapy and transcatheter arterial embolization chemotherapy on nephroblastoma in children. 【Methods】 Children with nephroblastoma admitted to our hospital from January 2010 to December 2019 were selected retrospectively as the study objects. Among them, 48 cases received preoperative chemotherapy by transcranial arterial embolization as the observation group, and 33 cases received systemic intravenous chemotherapy as the control group. The tumor volume reduction rate, tumor necrosis rate, capsule integrity rate, overall effective rate of preoperative chemotherapy, total tumor resection rate, 2-year tumor-free survival rate and adverse reactions were observed and compared in the two groups. 【Results】 Tumor volume reduction rate, tumor necrosis rate, capsule integrity rate, overall effective rate of preoperative chemotherapy and total tumor resection rate were all higher in the observation group than in the control group, and the incidence of adverse reactions was lower than that in the control group, with statistically significant differences (P<0.05).The 2-year tumor-free survival rate in the control group (94%) was higher than that in the observation group (88%), but the difference was not statistically significant (P<0.05). 【Conclusion】 Compared to systemic intravenous chemotherapy, preoperative transcranial arterial embolization is more beneficial to surgical resection, with higher efficacy and fewer adverse reactions in children with nephroblastoma. However, it does not show a better advantage in 2-year tumor-free survival rate, so it is necessary to further expand the sample size and follow up time for clinical study.
刘宇, 何军, 何天衢, 黄亚雄, 赵夭望. 儿童肾母细胞瘤术前全身静脉化疗与经导管动脉栓塞化疗临床疗效对比研究[J]. 医学临床研究, 2021, 38(2): 230-232.
LIU Yu, HE Jun, He Tian-qu, et al. Comparative Study of Preoperative Systemic Intravenous Chemotherapy and Transcatheter Arterial Embolization Chemotherapy in Children with Nephroblastoma. JOURNAL OF CLINICAL RESEARCH, 2021, 38(2): 230-232.
2021, Vol. 38 
