医学临床研究
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医学临床研究  2021, Vol. 38 Issue (1): 58-60    DOI: 10.3969/j.issn.1671-7171.2021.01.017
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瘦素、N-Cadherin在大肠癌中的表达及临床意义*
李美玲1, 刘红兵2, 张海明2, 汪砥2**
1.长沙市中心医院肿瘤科,湖南 长沙 410006;
2.湘潭市第一人民医院,湖南 湘潭 411101
Expression and Clinicopathological Significance of Leptin and N-Cadherin Expression in Patients with Colorectal Cancer
LI Mei-lin, LIU Hong-bin, ZHANG Hai-ming, et al
Changsha City Central Hospital Oncology Department Hunan Province Changsha 410006
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摘要 【目的】探讨瘦素、N-Cadherin蛋白表达与大肠癌临床病理特征之间的关系。【方法】采用免疫组织化学SP法检测蛋白瘦素、N-Cadherin在120例大肠癌中的表达并分析与临床病例资料的关系。【结果】瘦素、N-Cadherin在大肠癌中的阳性表达率分别为75.8%(91/120)和68.3%(82/120);瘦素与N-Cadherin的高表达均与大肠癌的浸润深度、临床分期、淋巴结转移、分化程度密切相关(P<0.05);大肠癌组织中瘦素、N-Cadherin的表达呈显著正相关,差异有统计学意义(P<0.01)。【结论】瘦素、N-Cadherin可能在大肠癌的发生、发展中起相互协同作用,二者可能作为判断大肠癌预后及指导临床治疗的指标。
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李美玲
刘红兵
张海明
汪砥
关键词 肠肿瘤/病理学瘦素/分析钙黏着糖蛋白类/分析免疫组织化学    
Abstract:【Objective】To investigate the relationship of leptin and N-Cadherin protein expression with clinicopathological features in colorectal cancer. 【Methods】The expression of leptin and N-Cadherin protein was evaluated by immunohistochemistry in 120 cases of colorectal cancer. The relationship between the staining pattern and clinicopathogical features was analyzed.【Results】The positive rates of leptin and N-Cadherin protein in colorectal cancer were 75.8% (91/120) and 68.3%(82/120), respectively. The expression intensity of leptin and N-Cadherin protein was related to invasive depth, TNM stages, lymph node metastasis and tumor differentiation of colorectal cancer. The difference was statistically significant (P<0.05). In colorectal cancer tissues, the leptin expression was positively correlated with N-Cadherin expression; and the difference was statistically significant (P<0.001).【Conclusion】Leptin and N-Cadherin may play an important role in the occurrence and development of colorectal cancer. The detection of leptin and N-Cadherin may be helpful for the evaluation of prognosis and treatment for colorectal cancer patients.
Key wordsIntestinal Neoplasms/PA    Leptin/AN    Cadherins/AN    Immunohistochemistry
收稿日期: 2020-12-04     
中图分类号:  R735.34  
通讯作者: **: E mail:di wang800122@163.com   
引用本文:   
李美玲, 刘红兵, 张海明, 汪砥. 瘦素、N-Cadherin在大肠癌中的表达及临床意义*[J]. 医学临床研究, 2021, 38(1): 58-60.
LI Mei-lin, LIU Hong-bin, ZHANG Hai-ming, et al. Expression and Clinicopathological Significance of Leptin and N-Cadherin Expression in Patients with Colorectal Cancer. JOURNAL OF CLINICAL RESEARCH, 2021, 38(1): 58-60.
链接本文:  
http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2021.01.017     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2021/V38/I1/58
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