医学临床研究
  2025年4月5日 星期六           首 页    |    期刊简介    |    编委会    |    投稿指南    |    期刊订阅    |    广告合作    |    留言板    |    联系我们    |    English
医学临床研究  2020, Vol. 37 Issue (2): 230-232    DOI: 10.3969/j.issn.1671-7171.2020.02.021
  论著 本期目录 | 过刊浏览 | 高级检索 |
Hcy、脂蛋白a、L-FABP水平变化与DN患者早期肾损伤的关系
周鑫, 丁巍, 韩正刚
辽宁省鞍山市中心医院铁东院区,辽宁 鞍山 114000
Relationship of Hcy, lipoprotein a and L-FABP Levels with Early Renal Injury in Diabetic Nephropathy Patients
ZHOU Xin, DING Wei, HAN Zheng-gang
Tiedong Hospital, Anshan Central Hospital, Liaoning Province,114000
全文: PDF (0 KB)   HTML (1 KB) 
输出: BibTeX | EndNote (RIS)      
摘要 【目的】探讨同型半胱氨酸(Hcy)、脂蛋白a、肝型脂肪酸结合蛋白(L-FABP)在糖尿病肾病(DN)早期肾损伤中的变化及其临床意义。【方法】本院收治的60例2型糖尿病患者(T2DM组)、60例2型糖尿病伴微量白蛋白尿患者(MA组)、60例2型糖尿病肾损伤达到临床期患者(CN组)及60例健康体检者(对照组)为研究对象;比较四组研究对象的Hcy、脂蛋白a、L-FABP水平及肾功能指标;并采用线性相关法探讨Hcy、脂蛋白a、L-FABP水平与患者肾功能指标变化的关系。【结果】T2DM组、MA组及CN组的Hcy、脂蛋白a、L-FABP水平均显著高于对照组(P<0.05),MA组及CN组的Hcy、脂蛋白a、L-FABP水平显著高于T2DM组(P<0.05),CN组的Hcy、脂蛋白a、L-FABP水平显著高于MA组(P<0.05);CN组的血尿素氮(BUN)、血肌酐(SCr)水平显著高于T2DM组、MA组及对照组(P<0.05),MA组、CN组的尿微量白蛋白排泄率(UAER)值高于T2DM组(P<0.05),CN组的UAER值高于MA组(P<0.05);UAER范围>20 μg/min的T2DM患者的Hcy、脂蛋白a、L-FABP水平与SCr、UAER呈显著的正相关关系(P<0.05)。【结论】DN患者Hcy、脂蛋白a、L-FABP水平显著地升高,并且与患者肾功能损害和病情程度具有相关性。
服务
把本文推荐给朋友
加入我的书架
加入引用管理器
E-mail Alert
RSS
作者相关文章
周鑫
丁巍
韩正刚
关键词 糖尿病肾病半胱氨酸/血液脂肪酸结合蛋白质类/血液    
Abstract【Objective】To investigate the changes and value of homocysteine (Hcy), lipoprotein a and liver fatty acid binding protein (L-FABP) in early renal injury of diabetic nephropathy (DN).【Methods】The study contained patients with type 2 diabetes mellitus (T2DM group,n=60), type 2 diabetes mellitus with microalbuminuria (MA group,n=60), type 2 diabetic kidney injury (CN group,n=60) and healthy volunteers as the control group (n=60). The levels of Hcy, lipoprotein a, L-FABP and renal function were compared in the four groups. The relationship of levels of Hcy, lipoprotein a and L-FABP with changes in renal function of patients was investigated by a linear correlation method.【Results】The levels of Hcy, lipoprotein a and L-FABP in the T2DM group, MA group and CN group were significantly higher than those in the control group (P<0.05). Hcy, lipoprotein a and L-FABP levels in the MA group and CN group were higher than those in the T2DM group. The levels of Hcy, lipoprotein a and L-FABP in the CN group was significantly higher than those in the MA group (P<0.05). The levels of BUN and SCr in the CN group were significantly higher than those in the T2DM group, the MA group and the control group (P<0.05). The UAER values of the MA group and the CN group were higher than those of the T2DM group (P<0.05); and the UAER value of the CN group was higher than that of the MA group (P<0.05); The levels of Hcy, lipoprotein a and L-FABP in the T2DM patients with >20μg/min were significantly positively correlated with SCr and UAER (P<0.05).【Conclusion】The levels of Hcy, lipoprotein a, and L-FABP in patients with DN were significantly elevated and closely correlated with renal dysfunction in patients.
Key wordsDiabetic Nephropathies    Cysteine/BL    Liver-type Fatty Acid-binding Protein/BL
收稿日期: 2018-07-19     
PACS:  R587.24  
引用本文:   
周鑫, 丁巍, 韩正刚. Hcy、脂蛋白a、L-FABP水平变化与DN患者早期肾损伤的关系[J]. 医学临床研究, 2020, 37(2): 230-232.
ZHOU Xin, DING Wei, HAN Zheng-gang. Relationship of Hcy, lipoprotein a and L-FABP Levels with Early Renal Injury in Diabetic Nephropathy Patients. JOURNAL OF CLINICAL RESEARCH, 2020, 37(2): 230-232.
链接本文:  
http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2020.02.021     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2020/V37/I2/230
版权所有 © 2013 医学临床研究杂志社  湘ICP备13012052号-1
办公地址:湖南省长沙市芙蓉区新军路43号煤炭大院主办公楼6楼621、623、632、636室 邮编:410011 电话(传真):0731-84824007 E-mail:jcr_cs.hn@vip.163.com
技术支持:北京玛格泰克科技发展有限公司 技术支持:support@magtech.com.cn