Abstract：【Objective】To investigate the changes and significance of serum bilirubin (TB) and uric acid (UA) levels in patients with type 2 diabetic nephropathy.【Methods】Among the type 2 diabetic patients diagnosed and treated in our hospital, 30 patients with normal urinary albumin excretion rate (UAER < 30mg/24h) were in the normal group, 30 patients with early type 2 diabetic nephropathy (DN) (30~300 mg/24h) were in the early group, and 30 patients with DN (>300 mg/24h) were in the DN group.The condition of diabetes mellitus, renal function index, serum TB and UA levels and their correlation with renal function index were compared among the three groups.【Results】HbA1c and fasting C-peptide in the DN group were significantly higher than those in the normal group and the early group (P<0.05); HbA1c and fasting C-peptide in the early group were significantly higher than those in the normal group (P<0.05); UAER and serum creatinine (SCr) in the DN group were significantly higher than those in the normal group and the early group (P<0.05); and endogenous creatinine clearance rate (CCr) in the early group was significantly higher than those in the normal group and the early group (P<0.05). UA in the DN group was significantly higher than that in the normal group (P<0.05), TB in the DN group was significantly lower than that in the normal group and the early group (P<0.05), UA in the early group was significantly higher than that in the normal group (P<0.05), TB in serum was negatively correlated with UAER, SCr and CCr (P<0.05), UA level was positively correlated with UAER, SCr and CCr (P<0.05). 【Conclusion】The occurrence and development of type 2 diabetic nephropathy is accompanied by the decrease of serum TB and the increase of UA level, which can be used as a new target for early diagnosis and clinical treatment of DN.
黄贵锐, 孙国明. 2型糖尿病肾病患者血清胆红素及血尿酸水平的变化及意义[J]. 医学临床研究, 2019, 36(6): 1066-1068.
HUANG Gui-rui, SUN Guo-ming. Changes and Significance of Serum Bilirubin and Uric Acid Levels in Patients with Type 2 Diabetic Nephropathy. JOURNAL OF CLINICAL RESEARCH, 2019, 36(6): 1066-1068.
2019, Vol. 36 
