CRP、PCT及ESR在后路椎弓根系统内固定术后切口感染患者中的表达及其意义

doi:10.3969/j.issn.1671-7171.2020.02.020

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摘要 【目的】探讨C反应蛋白(CRP)、降钙素原(PCT)及红细胞沉降率(ESR)在后路椎弓根系统内固定术后切口感染患者血清中的表达及其意义。【方法】选择2016年9月至2018年4月在本院行后路椎弓根系统内固定术后切口感染患者42例为观察组(浅部感染17例,深部感染25例),并选择同期行后路椎弓根系统内固定术后未发生感染患者78例为对照组。比较两组患者术前及术后1、3、5、7 d血清CRP、PCT及ESR水平,并分析其与感染的相关性。【结果】两组患者术前血清CRP、PCT及ESR水平比较差异无统计学意义(P>0.05);术后1、3、5、7 d,观察组血清CRP、PCT及ESR水平均明显高于同组术前和同期对照组,差异均有统计学意义(P<0.05)。术前和术后1 d,浅部感染和深部感染患者血清CRP、PCT及ESR水平比较差异无统计学意义(P>0.05);术后3、5、7 d,深部感染患者血清CRP、PCT及ESR水平均明显高于同期浅部感染患者,差异均有统计学意义(P<0.05)。Pearson相关分析显示:后路椎弓根系统内固定术后切口感染患者血清CRP、PCT及ESR水平与白细胞计数呈正相关。观察组42例感染患者标本培养,共分离出致病菌67株,其中革兰阳性菌44株,占65.67%,革兰阴性菌19株,占28.36%,真菌4株,占5.97%。【结论】后路椎弓根系统内固定术后切口感染患者血清CRP、PCT及ESR水平与感染密切相关,且感染以革兰阳性菌为主。

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	李大鹏
	李忠强

关键词 ：骨折固定术,内, 脊柱骨折, 感染

Abstract：【Objective】To investigate the expression and significance of C-reactive protein (CRP), procalcitonin (PCT) and erythrocyte sedimentation rate (ESR) in the serum of patients with incision infection after posterior pedicle system internal fixation.【Methods】From September 2016 to April 2018, 42 patients with incision infection after posterior pedicle system internal fixation were selected as the observation group (17 cases with superficial infection and 25 cases with deep infection), and 78 patients without infection after posterior pedicle system internal fixation were selected as the control group. The serum levels of CRP, PCT and ESR were compared before and 1,3,5,7 days after operation, and the correlation between them and infection was analyzed.【Results】There was no significant difference in the levels of CRP, PCT and ESR between the two groups (P>0.05); on the 1st, 3rd, 5th and 7th day after operation, the levels of CRP, PCT and ESR in the observation group were significantly higher than those in the same group before surgery and those of the control group at the same time (P<0.05). There was no significant difference in the levels of serum CRP, PCT and ESR between patients with Asabu infection and those with deep infection before and 1 d after operation (P>0.05). The levels of serum CRP, PCT and ESR in patients with deep infection were significantly higher than those in patients with shallow infection at 3, 5 and 7 d after operation (P<0.05).Pearson correlation analysis showed that serum CRP, PCT and ESR levels were positively correlated with leukocyte count in patients with incision infection after posterior pedicle system internal fixation. In the observation group, 67 strains of pathogenic bacteria were isolated from 42 infected patients, of which 44 were Gram-positive bacteria (65.67%), 19 were Gram-negative bacteria (28.36%) and 4 were fungi (5.97%).【Conclusion】The levels of CRP, PCT and ESR in patients with incision infection after posterior pedicle system internal fixation are closely related to the infection, and the main infection is Gram-positive bacteria.

Key words： Fracture fixation,internal Spinal fractures Infection

收稿日期: 2019-06-25

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引用本文:

李大鹏, 李忠强. CRP、PCT及ESR在后路椎弓根系统内固定术后切口感染患者中的表达及其意义[J]. 医学临床研究, 2020, 37(2): 226-229.
LI Da-peng, LI Zhong-qiang. Expression and Significance of CRP, PCT and ESR in Patients with Incision Infection after Posterior Pedicle System Internal Fixation. JOURNAL OF CLINICAL RESEARCH, 2020, 37(2): 226-229.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2020.02.020 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2020/V37/I2/226

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