高血压患者的血浆动脉硬化指数与尿酸水平的相关性研究

doi:10.3969/j.issn.1671-7171.2020.10.004

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摘要 【目的】 探讨血浆动脉硬化指数(Plasma arteriosclerosis index,AIP)与尿酸水平在不同高血压分级患者中的关系。【方法】 选择2018年1~12月于本院心血管内科初次就诊的443例高血压患者为研究对象,根据高血压分级标准将患者分为高血压1级组(n=102)、高血压2级组(n=177)、高血压3级组(n=164)。采用全自动血细胞及生化免疫分析仪检测患者血液生化指标,同时记录患者的一般临床资料。【结果】 三组间年龄、体质量指数(BMI)、尿酸(UA)、肌酐(Cr)、胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、非高密度脂蛋白胆固醇(non-HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白B (APOB)、血浆动脉粥样硬化指数(AIP)比较,差异有统计学意义(P<0.05)。高尿酸血症组、非高尿酸血症组患者不同高血压分级、UA、TG、non-HDL-C、HDL-C、APOA1、AIP比较,差异有统计学意义(P<0.05)。用Spearman相关性分析,UA与AIP、TG、non-HDL-C、APOB呈正相关(P<0.05);与HDL-C、载脂蛋白A1 (APOA1)呈负相关(P<0.05)。高血压3级、2级、1级患者AIP与UA均呈正相关(r_3级=0.617,P<0.01;r_2级=0.59,P<0.01;r_1级=0.35,P<0.01)。AIP对于高尿酸血症患者具有较好的预测价值(P<0.01),ROC曲线下面积AUC=0.855,95%CI[0.815,0.895],灵敏度为87.5%,特异度为73.5%。【结论】 AIP与高血压患者血UA水平呈正相关,在不同的高血压分级下,患者的血尿酸水平及AIP具有显著性差异,分级越高,AIP以及血尿酸水平越高。

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关键词 ：高血压, 动脉硬化, 尿酸

Abstract：【Objective】 To investigate the relationship between plasma arteriosclerosis index (AIP) and uric acid level in patients with different grades of hypertension.【Methods】 A total of 443 patients with hypertension who were treated for the first time in the Department of cardiovascular medicine of our hospital from January to December 2018 wae selected as the research objects. According to the classification standard of hypertension, the patients were divided into three groups:hypertension group 1 (n=102), hypertension group 2 (n=177), hypertension group 3 (n=164). The blood biochemical indexes were detected by automatic blood cell and biochemical immune analyzer, and the general clinical data of patients were recorded at the same time.【Results】 There were significant differences in age, body mass index (BMI), uric acid (UA), creatinine (CR), cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (apoB), and plasma atherosclerotic index (AIP) among the three groups. There were significant differences in the levels of hypertension, UA, TG, non-HDL-C, HDL-C, ApoA1 and AIP between the hyperuricemia group and the non hyperuricemia group (P<0.05). Spearman correlation analysis showed that UA was positively correlated with AIP, TG, non-HDL-C and apoB (P<0.05), and negatively correlated with HDL-C and ApoA1 (P<0.05). AIP was positively correlated with UA in patients with grade 3, 2 and 1 hypertension (r₃=0.617, P<0.01; r₂=0.59, P<0.01;r₁=0.35, P<0.01). AIP had a good predictive value for patients with hyperuricemia (P<0.01). The area under ROC curve AUC=0.855, 95% CI(0.815, 0.895), sensitivity 87.5%, specificity 73.5%.【Conclusion】 AIP is positively correlated with the UA level of hypertension patients. Under different hypertension grades, the blood uric acid level and AIP level of patients have significant differences. The higher the grading, the higher the level of AIP and the higher the level of blood uric acid.

Key words： Hypertension Arteriosclerosis Uric Acid

收稿日期: 2020-02-04

PACS:

R544.1

基金资助:陕西省卫生健康科研基金(2018D013)

通讯作者: **E-mail:ligxin@163.com

引用本文:

王露朝, 李公信, 柴小奇, 陈玉军, 李子杰. 高血压患者的血浆动脉硬化指数与尿酸水平的相关性研究[J]. 医学临床研究, 2020, 37(10): 1454-1457.
WANG Lu-zhao, LI Gong-xin, CHAI Xiao-qi, et al. Correlation between Plasma Arteriosclerosis Index and Uric Acid Level in Patients with Hypertension. JOURNAL OF CLINICAL RESEARCH, 2020, 37(10): 1454-1457.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2020.10.004 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2020/V37/I10/1454

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