Abstract：【Objective】To explore the diagnostic value of forced expiratory volume in 1 second (FEV1) and inspiratory capacity (IC) in asthma-COPD overlap (ACO). 【Methods】A total of 47 patients with chronic obstructive pulmonary disease (COPD,the control group) and 52 patients with ACO (the observation group) admitted to our hospital from February 2020 to February 2025 were selected. FEV1 and IC were detected in both groups. Patients were graded according to lung function. Spearman correlation coefficient was used to analyze the correlation between FEV1, IC and lung function grading. Receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of FEV1 combined with IC for ACO. 【Results】FEV1 and IC in the observation group were lower than those in the control group (P<0.05); FEV1 and IC in patients with grade Ⅳ were lower than those in patients with grade Ⅰ, Ⅱ and Ⅲ (P<0.05). Correlation analysis showed that FEV1 and IC were negatively correlated with lung function grading (P<0.05). ROC analysis results showed that the sensitivity and specificity of FEV1 combined with IC in diagnosing ACO patients were 84.6% and 72.3% respectively, and the area under the ROC curve was 0.806, which were better than those of single index detection. 【Conclusion】FEV1 and IC are significantly decreased in patients with ACO, and are negatively correlated with lung function grading. The combined detection of FEV1 and IC has certain diagnostic value for ACO, with good clinical application prospects.
刘源, 马宁. FEV1、IC对哮喘合并慢性阻塞性肺疾病的诊断价值[J]. 医学临床研究, 2025, 42(7): 1116-1118.
LIU Yuan, MA Ning. Diagnostic Value of FEV1 and IC in Asthma-COPD Overlap. JOURNAL OF CLINICAL RESEARCH, 2025, 42(7): 1116-1118.
2025, Vol. 42 
