Abstract：【Objective】To explore the predictive value of serum lactate dehydrogenase (LDH) and its isoenzymes, fibrinogen (FIB)/albumin (ALB) ratio (FAR) for the prognosis of patients with acute exacerbation of chronic obstructive pulmonary disease (COPD). 【Methods】 The clinical data of 81 patients with acute exacerbation of COPD treated in our hospital from January 2022 to June 2024 were retrospectively analyzed. According to the prognosis within 1 year after treatment, the patients were divided into poor prognosis group (n=32) and good prognosis group (n=49). The general data, serum LDH and its isoenzymes, and FAR were compared between the two groups. Logistic multivariate regression was used to analyze the risk factors for poor prognosis in patients with acute exacerbation of COPD, and receiver operating characteristic (ROC) curve was used to analyze the predictive value of serum LDH and its isoenzymes, FAR for the prognosis of such patients. 【Results】The FAR and serum LDH1, LDH2, LDH4, LDH5, total LDH levels in the poor prognosis group were higher than those in the good prognosis group, with statistically significant differences (P<0.05). High levels of FAR, serum LDH1, LDH4, LDH5, and total LDH were risk factors for poor prognosis in patients with acute exacerbation of COPD (P<0.05). ROC curve analysis showed that FAR, serum LDH1, LDH4, LDH5, and total LDH levels all had certain predictive value for the prognosis of patients with acute exacerbation of COPD, and the combined prediction value of these indicators was better than that of single indicator. 【Conclusion】Serum LDH and its isoenzymes, FAR have certain predictive value for the prognosis of patients with acute exacerbation of COPD, and the combined detection of these indicators has a better predictive value than single indicator.
苏慧, 董鹏飞, 许沛, 马晓. 血清LDH及其同工酶、FAR对COPD急性加重期患者预后的预测价值[J]. 医学临床研究, 2025, 42(6): 959-961.
SU Hui, DONG Pengfei, XU Pei, et al. Predictive Value of Serum LDH and its Isoenzymes, FAR for Prognosis of Patients with Acute Exacerbation of COPD. JOURNAL OF CLINICAL RESEARCH, 2025, 42(6): 959-961.
2025, Vol. 42 
