Abstract：【Objective】To explore the clinical efficacy of tofacitinib in the treatment of patients with rheumatoid arthritis (RA) complicated with interstitial lung disease (ILD) and its influence on peripheral lymphocyte subsets of these patients. 【Methods】A total of 120 patients with RA complicated with ILD diagnosed and treated in our hospital from March 2020 to March 2023 were selected and divided into the control group (treated with methylprednisolone tablets) and the observation group (treated with tofacitinib combined with methylprednisolone tablets) according to different treatment regimens, with 60 cases in each group. Improvement of clinical symptoms (morning stiffness of the joints, joint swelling and joint pain), laboratory indicators, pulmonary function indicators and peripheral lymphocyte subsets were compared between the two groups. 【Results】After the treatment, the improvement of clinical symptoms in the observation group was better than those in the control group. After treatment, the levels of tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), D-dimer (D-D), rheumatoid factor (RF), and salivary liquid sugar chain antigen (KL-6) in the observation group were significantly lower than those in the control group. After treatment, the vital capacity (VC), total lung capacity (TLC), forced vital capacity (FVC), and the lung's diffusion capacity for carbon monoxide (DLCO) in the observation group were significantly higher than those in the control group. After treatment, CD4+ and CD4+/CD8+ in both groups significantly increased, while CD8+ significantly decreased. Moreover, CD4+ and CD4+/CD8+ in the observation group were higher than those in the control group, while CD8+ was lower than that in the control group. The differences were statistically significant (P<0.05). 【Conclusion】Tofacitinib in the treatment of patients with RA complicated with ILD can effectively improve the clinical symptoms, laboratory indicators and pulmonary function indicators of patients, and enhance the immune function.
王媛媛, 杨海阳, 曹娟. 托法替布治疗类风湿关节炎合并间质性肺病患者的临床疗效及对患者外周淋巴细胞亚群的影响[J]. 医学临床研究, 2025, 42(4): 659-662.
WANG Yuanyuan, YANG Haiyang, CAO Juan. Effect of Tofacitinib on Peripheral Lymphocyte Subpopulations in Patients with Rheumatoid Arthritis Complicated with Interstitial Lung Disease. JOURNAL OF CLINICAL RESEARCH, 2025, 42(4): 659-662.
2025, Vol. 42 
