血清sCD14联合sCD30对老年慢性阻塞性肺疾病合并肺部真菌感染的诊断价值

doi:10.3969/j.issn.1671-7171.2025.02.014

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摘要【目的】探讨血清可溶性白细胞分化抗原14(sCD14)联合sCD30对老年慢性阻塞性肺疾病(COPD)合并肺部真菌感染的诊断价值。【方法】选取2021年4月至2023年6月本院收治的80例老年COPD患者,以真菌培养为金标准,将患者分为A组(n=23,合并肺部真菌感染)和B组(n=57,未合并肺部真菌感染),采用酶联免疫吸附法检测两组患者入院第2天血清sCD14、sCD30水平,分析老年COPD合并肺部真菌感染的影响因素及血清sCD14、sCD30诊断老年COPD合并肺部真菌感染的效能。【结果】A组急性生理学与慢性健康状况评价Ⅱ(APACHEⅡ)评分及sCD14、sCD30、C反应蛋白(CRP)水平均高于B组(P<0.05)。二元 Logistic回归分析显示:APACHEⅡ评分及sCD14、sCD30、CRP水平高是老年COPD患者发生肺部真菌感染的危险因素(P<0.05)。APACHEⅡ评分联合血清sCD14、sCD30、CRP检测诊断老年COPD患者合并肺部真菌感染的效能均高于单一指标检测。【结论】APACHEⅡ评分联合血清sCD14、sCD30、CRP检测诊断老年COPD合并肺部真菌感染的临床价值较高。

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	杨建华

关键词 ：肺疾病, 慢性阻塞性, 肺疾病, 真菌性, 脂多糖受体

Abstract：【Objective】To investigate the diagnostic value of serum soluble 14 (sCD14) combined with sCD30 in elderly patients with chronic obstructive pulmonary disease (COPD) complicated with pulmonary fungal infection.【Methods】A total of 80 elderly patients with COPD admitted to our hospital from April 2021 to June 2023 were selected and divided into group A (n=23, combined with pulmonary fungal infection) and group B (n=57, not combined with pulmonary fungal infection), using fungal culture as the gold standard. Serum sCD14 and sCD30 levels were detected by ELISA on the second day of admission in the two groups, and the influencing factors of senile COPD combined with pulmonary fungal infection and the efficacy of serum sCD14 and sCD30 in diagnosis of senile COPD combined with pulmonary fungal infection were analyzed.【Results】The Acute physiology and Chronic Health status Scoring System Ⅱ (APACHE Ⅱ) scores and the levels of sCD14, sCD30 and C-reactive protein (CRP) in group A were higher than those in group B (P<0.05). Binary Logistic regression analysis showed that APACHE Ⅱ score and high levels of sCD14, sCD30 and CRP were risk factors for pulmonary fungal infection in elderly patients with COPD (P<0.05). APACHE Ⅱ score combined with serum sCD14, sCD30 and CRP were more effective than single index in predicting pulmonary fungal infection in elderly patients with COPD.【Conclusion】APACHEⅡ score combined with serum sCD14, sCD30 and CRP has a high predictive value for pulmonary fungal infection in elderly patients with COPD.

Key words： Pulmonary Disease, Chronic Obstructive Lung Diseases, Fungal Lipopolysaccharide Receptors

收稿日期: 2024-05-09

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R563

引用本文:

杨建华. 血清sCD14联合sCD30对老年慢性阻塞性肺疾病合并肺部真菌感染的诊断价值[J]. 医学临床研究, 2025, 42(2): 225-227.
YANG Jianhua. Diagnostic Value of Serum sCD14 Combined with sCD30 in Elderly Patients with Chronic Obstructive Pulmonary Disease Complicated with Pulmonary Fungal Infection. JOURNAL OF CLINICAL RESEARCH, 2025, 42(2): 225-227.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2025.02.014 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2025/V42/I2/225

[1] 苏彦萍,吴芹,孙晓伟,等.2005-2021年北京市通州区慢性阻塞性肺疾病死亡水平及疾病负担分析[J].现代预防医学, 2022,49(19):3474-3480.
[2] 李小红,沈晓飞,闫雪.慢性阻塞性肺疾病急性加重期的中医证型结合嗜酸性粒细胞分层的临床意义[J].浙江中医药大学学报, 2021,45(9):1013-1021.
[3] YANG I A, JENKINS C R, SALVI S S. Chronic obstructive pulmonary disease in never-smokers: risk factors, pathogenesis, and implications for prevention and treatment[J].Lancet Respir Med,2022,10(5):497-511.
[4] 段友红,梁友宝,乔林爽,等.慢性阻塞性肺疾病疾病急性加重患者下呼吸道感染病原菌分布,耐药性及危险因素分析[J].医学动物防制, 2022, 38(12):1171-1175.
[5] 罗丹,陈晶晶,胡忠,等.慢性阻塞性肺疾病急性加重期合并肺部感染患者肾损伤的危险因素及预测模型建立[J].中华医院感染学杂志, 2023,33(12):1800-1803.
[6] 张磊,王梅英,王瑞刚,等.血清sCD14、CRP、PCT在急性胰腺炎中的表达及与APACHEⅡ、BISAP的相关性[J].现代生物医学进展, 2022,22(8):1510-1513.
[7] 王欣,梁艳丽,李艳秋.血清TK1和sCD30水平与T细胞淋巴瘤患者临床特征的相关性[J].海军医学杂志, 2022, 43(1):65-69.
[8] 中华医学会呼吸病学分会慢性阻塞性肺疾病学组,中国医师协会呼吸医师分会慢性阻塞性肺疾病工作委员会.慢性阻塞性肺疾病诊治指南(2021年修订版)[J].中华结核和呼吸杂志, 2021, 44(3):170-206.
[9] 中华医学会呼吸病学分会感染学组.肺真菌病诊断和治疗专家共识[J].中华结核和呼吸杂志, 2007, 30(11):821-834.
[10] LICHTNER G, BALZER F, HAUFE S,et al. Predicting lethal courses in critically ill COVID-19 patients using a machine learning model trained on patients with non-COVID-19 viral pneumonia[J].Sci Rep,2021,11(1):13205.
[11] MATHIOUDAKIS A G, JANSSENS W, SIVAPALAN P,et al.Acute exacerbations of chronic obstructive pulmonary disease: in search of diagnostic biomarkers and treatable traits[J].Thorax,2020,75(6):520-527.
[12] 黄娟,张华根,温雅.慢性阻塞性肺疾病急性加重期继发下呼吸道真菌感染风险模型的构建[J].中国医刊, 2023, 58(8):873-878.
[13] GINTER K, SCHWAB F, BEHNKE M,et al.SAPS2, APACHE2, SOFA, and Core-10-TISS upon admission as risk indicators for ICU-acquired infections: a retrospective cohort study[J].Infection,2023,51(4):993-1001.
[14] 钟声,方昕,刘冰.血ESR、SDF1、sCD14预测老年股骨粗隆骨折患者术后感染的价值及其与转归的关系[J].山东医药 2021,61(29):78-81.
[15] 梁风岐,孙晓伟,王晓.血清sTREM-1、sCD14对血液透析患者导管相关感染的预测价值分析[J].系统医学, 2023, 8(1):5-9.
[16] 刘宜鑫,罗鹏,邱雪,等.sCD30在乙肝肝硬化急性失代偿患者中的表达及预后意义[J].重庆医学, 2022, 51(6):929-934.