Abstract：【Objective】To investigate the clinical efficacy of low-dose Tirofiban combined with mechanical thrombectomy in the treatment of acute cerebral infarction (ACI). 【Methods】 A total of 81 ACI patients who underwent vascular thrombectomy were randomly divided into a control group (40 cases) and an observation group (41 cases). The control group underwent mechanical thrombectomy and was treated postoperatively with a loading dose of 300 mg aspirin + 75 mg clopidogrel. The observation group received Tirofiban treatment in addition to the control group's regimen. The modified Thrombolysis in Cerebral Infarction (mTICI) score was used to compare the vascular recanalization rates of the two groups 24 hours after surgery. Serum levels of nitric oxide (NO) and endothelin-1 (ET-1), platelet aggregation rate, neurological function, and recovery were compared between the two groups before and 3 days after surgery. The incidence of adverse reactions was also compared. 【Results】 There was no statistically significant difference in the vascular recanalization rate between the two groups 24 hours after surgery (P>0.05). Three days post-surgery, the observation group had lower serum NO and ET-1 levels and lower platelet aggregation rate compared to the control group (all P<0.05). The observation group also had lower National Institutes of Health Stroke Scale (NIHSS) scores and Rankin scores compared to the control group (both P<0.05). There was no statistically significant difference in the overall incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】 Low-dose Tirofiban combined with mechanical thrombectomy for ACI can effectively improve blood flow and vascular endothelial function, alleviate brain tissue damage, and improve neurological function with good safety.
冯江伟, 王东梅, 李浩浩. 小剂量替罗非班联合机械取栓治疗急性脑梗死的临床疗效[J]. 医学临床研究, 2024, 41(9): 1402-1404.
FENG Jiangwei, WANG Dongmei, LI Haohao. Clinical Efficacy of Low-Dose Tirofiban Combined with Mechanical Thrombectomy in the Treatment of Acute Cerebral Infarction. JOURNAL OF CLINICAL RESEARCH, 2024, 41(9): 1402-1404.
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2024, Vol. 41 
