Abstract：【Objective】To explore the efficacy and safety of pre dilation of small balloons before catheter thrombolysis in the treatment of acute iliofemoral vein thrombosis patients.【Methods】A total of 116 patients with acute iliofemoral vein thrombosis admitted to our hospital from January 2018 to December 2021 were selected as the study subjects. According to the intervention method, they were divided into small balloon dilation combined with catheter thrombolysis treatment (observation group,n=53) and direct catheter thrombolysis treatment (control group, n=63). Comparison was made between two groups of patients before treatment and one week after treatment, including the circumference difference between the healthy and affected sides, venous patency score, venous patency rate, prothrombin time (PT), fibrinogen (FIB) levels, activated partial enzyme thrombin time (APTT), thrombin time (TT), and white blood cell count (WBC) D-dimer (D-D) was used to record the incidence of bleeding, thrombolysis time, dosage of urokinase, and length of hospital stay in two groups of patients.【Results】After treatment, the difference in thigh circumference and calf circumference between the two groups of patients was lower than before treatment, and the observation group was lower than the control group, with statistical significance (P<0.05). After treatment, the deep vein patency scores of both groups of patients were lower than before treatment, and the observation group was lower than the control group (P<0.05); The deep vein patency rate and bleeding incidence rate in the observation group were lower than those in the control group, and the difference was statistically significant (P<0.05). After treatment, two groups of patients TT The levels of APTT and PT were higher than before treatment, and the observation group was higher than the control group. The FIB levels in both groups were significantly lower than before treatment, and the observation group was lower than the control group (P<0.05). After treatment, the WBC and D-D levels in the observation group were lower than before treatment, and the observation group was lower than the control group (P<0.05). The thrombolysis time, urokinase dosage, and hospital stay in the observation group were all lower than those in the control group, and the differences were statistically significant (P<0.05).【Conclusion】The use of balloon pre dilation before catheter thrombolysis for the treatment of acute iliofemoral vein thrombosis can improve treatment efficacy, have high safety, and have advantages such as high venous patency rate, low dosage of thrombolytic drugs, short thrombolysis time, and low incidence of bleeding.
邱书森. 导管溶栓前小球囊预扩张治疗急性髂股静脉血栓患者的临床及安全性[J]. 医学临床研究, 2024, 41(5): 645-648.
QIU Shusen. Effect and Safety of Small Balloon Pre-Dilation before Catheter Thrombolysis in the Treatment of Acute Iliofemoral Vein Thrombosis Patients. JOURNAL OF CLINICAL RESEARCH, 2024, 41(5): 645-648.
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2024, Vol. 41 
