Abstract：【Objective】 To investigate the value of the Alberta Stroke Program Early CT Score (ASPECTS) in evaluating hemorrhagic transformation (HT) after alteplase thrombolysis in patients with acute cerebral infarction (ACI). 【Methods】 A total of 92 ACI patients treated with alteplase thrombolysis underwent cranial CT scans at initial diagnosis. The occurrence of HT after thrombolysis was observed, and patients were divided into the HT group and non-HT group accordingly. ASPECTS scores and related clinical data of the two groups were compared. The value of ASPECTS in assessing the risk of HT after thrombolysis was analyzed using the receiver operating characteristic (ROC) curve, and multivariate logistic regression was used to analyze the influencing factors of HT. 【Results】 Among the 92 ACI patients treated with thrombolysis, 11 had type 1 and 3 had type 2 of hemorrhagic infarction, while 10 had parenchymal hematoma type 1 and 2 had parenchymal hematoma type 2. So there were a total of 26 cases (28.26%) in the HT group. The rest 66 cases (71.74%) without HT were included in the non-HT group. The proportion of patients with atrial fibrillation and National Institutes of Health Stroke Scale (NIHSS) scores in the HT group were higher than that in the non-HT group (P<0.05), and the ASPECTS scores were lower in the HT group than in the non-HT group (P<0.05). ROC analysis confirmed that ASPECTS could be used to assess the risk of HT after thrombolysis in ACI patients, with a sensitivity of 80.32% and a specificity of 79.02%. Multivariate logistic regression analysis showed that atrial fibrillation, NIHSS score, and ASPECTS score were independent influencing factors for HT after thrombolysis (P<0.05). 【Conclusion】 The risk of HT after alteplase thrombolysis is high in ACI patients. ASPECTS can be used as an effective early predictor of HT occurrence: the lower the score, the higher the risk of HT.
吕贤坤, 李强, 徐来成, 闫凤全. ASPECTS 评分在急性脑梗死患者阿替普酶溶栓后出血转化评估中的价值[J]. 医学临床研究, 2024, 41(7): 1027-1030.
LYU Xiankun, LI Qiang, XU Laicheng, et al. Value of ASPECTS in Evaluating Hemorrhagic Transformation after Alteplase Thrombolysis in Patients with Acute Cerebral Infarction. JOURNAL OF CLINICAL RESEARCH, 2024, 41(7): 1027-1030.
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2024, Vol. 41 
