Abstract：【Objective】To observe the effect of sodium ferulate on renal interstitial fibrosis and urinary microprotein in patients with diabetic nephropathy. 【Methods】A total of 100 patients with diabetic nephropathy treated in the two hospitals were divided into the observation group and the control group according to random number table method,with 50 cases in each group. The control group was given basic treatment such as routine hypoglycemic and antihypertensive treatment,,While the observation group was given sodium ferulate injection on the basic treatment of the control group. Patients in both groups received treatment for 2 weeks. The therapeutic effects of the two groups were observed. Angiotensin Ⅱ(Ang Ⅱ),connective tissue growth factor (CTGF),type Ⅳ collagen (CⅣ),type Ⅲ procollagen (PCⅢ),blood urea nitrogen (BUN),blood creatinine(SCr),β2-microglobulin(β2-MG) and urinary microalbumin (UmAlb) were measured before and 1 month after treatment. The drug adverse reactions of the two groups were counted. 【Results】The total effective rate in observation group was significantly higher than that in control group (P<0.05).The levels of Ang Ⅱ,CTGF,C Ⅳ and PC Ⅲ in the two groups after treatment were significantly lower than those before treatment (P<0.05). After treatment,the levels of Ang Ⅱ,CTGF,C Ⅳ and PC Ⅲ in the observation group were significantly lower than those in the control group (P<0.05).The levels of SCr,BUN,β2-MG and UmAlb in both groups after treatment were significantly lower than before treatment (P<0.05).And the levels of SCr,BUN,β2-MG and UmAlb in observation group were significantly lower than those in control group after treatment (P<0.05).There was no significant difference in adverse reactions between the two groups (P>0.05). 【Conclusion】Treatment of diabetic nephropathy with sodium ferulate can effectively reduce renal interstitial fibrosis and urinary microprotein index,and protect renal function.No obvious adverse drug reactions were seen,which is worthy of clinical promotion.
2022, Vol. 39 
