Abstract：【Objective】 To investigate the value of diffusion weighted imaging (DWI) in the diagnosis of glomerulonephritis and its relationship with the severity of renal pathological damage. 【Methods】 A total of 56 patients with glomerulonephritis in our hospital were selected as the observation group,and 56 healthy subjects were selected as the control group. The general data of the two groups at admission,renal function[serum creatinine (SCR),urea nitrogen (BUN)],combined diseases,renal cortex and renal medulla performance diffusion coefficient (ADC) values,etc. were collected. Receiver operating characteristic (ROC) curve was used to analyze the diagnostic value of DWI related parameters in glomerulonephritis. The severity of renal pathological damage in the observation group was evaluated according to Katafuchi nephropathy scoring system,and ADC values of renal cortex and renal medulla in patients with different severity of pathological damage were compared to analyze their correlation with the severity of renal pathological damage. 【Results】There was no significant difference in the levels of SCR,BUN,age and sex ratio between the two groups (P>0.05); The ADC values of renal cortex and renal medulla in the observation group were lower than those in the control group (P<0.05). The ROC curve analysis showed that the ADC values of renal cortex and renal medulla had certain diagnostic value for glomerulonephritis,and the areas under the curve were 0.787 and 0.739 respectively. Among the 56 patients with glomerulonephritis,20 patients(35.71%) had no pathological damage to the kidney and were considered as normal group; 26 cases (46.43%) were mild damage,and were classified as mild group; 10 cases (17.86%) were moderate damage,and were classified as moderate group; No severe damage.The ADC values of renal cortex and renal medulla in the normal group were higher than those in the mild group and the moderate group (P<0.05); Katafuchi damage score in the normal group was lower than that in the mild group and moderate group(P<0.05). By Pearson test,ADC values of renal cortex and medulla were negatively correlated with pathological scores (P<0.05). 【Conclusion】 DWI related parameters have a certain diagnostic value for glomerulonephritis,and it has a certain correlation with the degree of renal pathological damage.
张磊, 李卓. 扩散加权成像相关参数诊断肾小球肾炎的价值及其与肾脏病理损害严重程度的关系[J]. 医学临床研究, 2022, 39(7): 977-980.
ZHANG Lei, LI Zhuo. Value of Diffusion Weighted Imaging in the Diagnosis of Glomerulonephritis and its Relationship with the Severity of Renal Pathological Damage. JOURNAL OF CLINICAL RESEARCH, 2022, 39(7): 977-980.
2022, Vol. 39 
