Abstract：【Objective】 To investigate the efficacy of eplerenone combined with enalapril in the treatment of type H hypertension with heart failure and its effects on N-terminal B-type pro-brain natriuretic peptide (NT-proBNP) and homocysteine(Hcy). 【Methods】 From January 2016 to January 2019, 104 patients with H-type hypertension complicated with chronic heart failure in our hospital were selected as the research objects, and they were divided into observation group and control group according to the random number table method, with 52 cases in each group. The control group was treated with eplerenone, while the observation group was treated with enalapril maleate and folic acid tablets on the basis of the control group for 3 months. The clinical efficacy, serum Hcy and NT-proBNP levels before and after treatment, left ventricular end diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD), left ventricular ejection fraction (LVEF), NYHA classification and incidence of adverse reactions were compared between the two groups. 【Results】 The clinical effective rate of the observation group was 92.31% (48/52), which was significantly higher than 76.92% (40/52) of the control group (χ2=4.727,P=0.03<0.05). After treatment, SBP, DBP and serum Hcy, NT-proBNP levels of the two groups were lower than before treatment, and the observation group was significantly lower than the control group, the difference was statistically significant (P<0.05); LVESD and LVEDD of the two groups were lower than those before treatment, and the observation group was significantly lower than the control group; LVEF was higher than that before treatment, and the observation group was significantly higher than the control group; NYHA grade was significantly improved, the differences were statistically significant (P<0.05); no serious adverse reactions occurred in the two groups during the treatment.【Conclusion】 Eplerenone combined with enalapril folic acid has good clinical effect in the treatment of H-type hypertension with chronic heart failure. It can effectively control the blood pressure and reduce the serum NT-proBNP and Hcy levels.
李刘文, 白红艳, 李岗峰. 依普利酮联合依那普利叶酸治疗H型高血压合并慢性心衰的疗效及对血清NT-proBNP、Hcy水平的影响[J]. 医学临床研究, 2021, 38(2): 199-201.
LI Liu-wen, BAI Hong-yan, LI Gang-feng. Efficacy of Eplerenone Combined with Enalapril in the Treatment of Type H Hypertension with Heart Failure and its Effects on NT-proBNP and Hcy. JOURNAL OF CLINICAL RESEARCH, 2021, 38(2): 199-201.
2021, Vol. 38 
