Abstract：【Objective】To investigate relationship of the expression of myeloid leukemia gene-1 (MCL-1) and NIK-IKK binding protein (NIBP) with tumor progression in colon cancer. 【Methods】Immunohistochemical staining was used to detect the expression of MCL-1 protein and NIBP protein in 82 cases of postoperative colon cancer tissues and corresponding adjacent tissues. The pathological parameters such as different TNM stage, tumor differentiation degree and lesion size were analyzed to reveal their relationship with positive expression rate of MCL-1 protein and NIBP protein. 【Results】The positive rates of MCL-1 protein and NIBP protein in colon cancer tissues were 68.29% and 60.98%, respectively, which were significantly higher than those in adjacent tissues (26.83% and 20.73%, respectively). The differences were statistically significant (P<0.05). The differential expression of MCL-1 protein and NIBP protein in colon cancer tissues with different tumor invasion depths, TNM stages, pathological differentiation, and lymph node metastasis were statistically significant (P<0.05). 【Conclusion】The expression of MCL-1 protein and NIBP protein in colon cancer tissues is significantly higher than that in adjacent tissues, which may be related to the progression of colon cancer.
范钰晨, 马月珍, 李铠男. 结肠癌组织中MCL-1、NIBP表达情况及其与肿瘤进展的相关性[J]. 医学临床研究, 2020, 37(11): 1678-1680.
FAN Yu-chen, MA Yue-zhen, LI Kai-nan. Relationship of MCL-1 and NIBP Expression in Colon Cancer Tissues with Tumor Progression. JOURNAL OF CLINICAL RESEARCH, 2020, 37(11): 1678-1680.
[1] El J T, Dalvi S D, Kim S, et al. Myeloid cell leukemia-1 protein expression and myeloid cell leukemia-1 gene amplification in non small cell lung cancer[J].Indian J Pathol Microbiol,2018, 61(1):27-30. [2] Yin W, Nie Y, Chen L, et al. Deregulation of microRNA-193b affects the proliferation of liver cancer via myeloid cell leukemia-1[J].Oncology Letters,2017, 15(3):2781-2788. [3] Bi L, Zhou B, Li H, et al. A novel miR-375-HOXB3-CDCA3/DNMT3B regulatory circuitry contributes to leukemogenesis in acute myeloid leukemia[J].BMC Cancer,2018, 18(1):182-183. [4] 刘殊,王士勇,张晖,等. NIBP 在结肠癌组织中的表达及临床意义[J].现代肿瘤医学,2015,23(7): 974-976. [5] 陈万青,郑荣寿,曾红梅,等.2011年中国恶性肿瘤发病和死亡分析[J].中国肿瘤,2015,24(1):1-10. [6] 吕龙,常春.结直肠癌术后复发相关标志物的研究进展[J].中国煤炭工业医学杂志,2013, 16(2):324-328. [7] 谭林,刘诗权,覃蒙斌,等.NIBP在结肠癌NF-KB非经典激活通路中的作用及其临床意义[J].世界华人消化杂志,2015,23(8):1238-l246. [8] Wang H, Liu S, Zhang X, et al. Tu1919 Clinical Significance of NIBP Expression in Human Colon Cancer Tissues[J].Gastroenterology,2013, 144(5):881. [9] Qin M, Liu S, Li A, et al. NIK- and IKKβ-binding protein promotes colon cancer metastasis by activating the classical NF-κB pathway and MMPs[J].Tumor Biol,2015, 37(5):5979-5990. [10] Zhang Y , Liu S , Wang H , et al. Elevated NIBP/TRAPPC9 mediates tumorigenesis of cancer cells through NFκB signaling[J].Oncotarget,2015, 6(8):6160-6178. [11] 杜冠魁,骆凯丽,庞驰,等.人Mcl -1基因启动子区结合蛋白的生物信息学分析[J].吉林医学,2016,37(12):2865.
2020, Vol. 37 
