外周血中循环肿瘤细胞与结肠癌患者进展及预后的相关性研究

doi:10.3969/j.issn.1671-7171.2020.11.025

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摘要【目的】探讨外周血中循环肿瘤细胞(CTCs)与结肠癌患者进展及预后的相关性。【方法】选取2018年1月至2019年12月本院收治的87例首诊拟行结肠癌根治术治疗的结肠癌患者的临床资料(观察组),选择同期拟行结肠息肉切除术治疗85例结肠息肉患者为对照组。检测两组患者术前外周血中CTCs阳性细胞,比较两组外周血CTCs阳性率,分析不同病理学特征结肠癌患者CTCs阳性率差异。所有患者随访3年,分析CTCs阳性与阴性结肠癌患者3年生存率及生存时间差异。【结果】观察组外周血中CTCs阳性细胞检出率为44.83%(39/87),显著高于对照组的3.53%(3/85),差异有统计学意义(χ²=39.732,P<0.05)。不同TNM分期、是否发生淋巴结转移、是否发生脉管浸润的结肠癌患者中外周血中CTCs阳性细胞检出率组间比较,差异具有统计学意义(P<0.05);不同分化程度、不同病灶大小、不同肿瘤部位的结肠癌患者外周血中CTCs阳性细胞检出率组间比较,差异无统计学意义(P>0.05)。CTCs阳性组患者的3年累积生存率19.10%,低于阴性组患者的45.20%(P<0.05);CTCs阳性组患者的中位生存时间28.0个月,低于阴性组患者的35.0个月(P<0.05)。【结论】结肠癌患者外周血中CTCs阳性细胞检测,对患者病情评估、预后判断均具有一定的指导意义。

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	胡佐宇
	崔正旅
	冯伟

关键词 ：结肠肿瘤/病理学, 肿瘤细胞, 循环/血液, 预后

Abstract：【Objective】To investigate the relationship of circulating tumor cells (CTCs) in peripheral blood with the development and prognosis of colon cancer. 【Methods】A total of 87 patients who underwent surgical treatment of colon cancer in our hospital were selected in the observation (colon cancer) group, and 85 patients with colon polyps who were treated with intestinal polyps were selected as the control group. The levels of CTCs in the peripheral blood of the two groups were measured. The positive rate of peripheral blood CTCs in the group and different CTCs positive rates in colon cancer patients with different pathological features were analyzed. All patients were followed up for 3 years to evaluated the difference in 3-year survival rate and survival time between CTCs positive and negative colon cancer patients. 【Results】The detection rate of CTCs positive cells in peripheral blood of colon cancer group was 44.83%, which was significantly higher than that of control group (3.53%). The difference was statistically significant (P<0.05). The detection rate of CTCs positive cells in peripheral blood of colon cancer patients with different TNM stages, lymph node metastasis, and vascular invasion were compared between groups; and the difference was statistically significant (P<0.05). The positive cells of CTCs in peripheral blood of colon cancer patients with different degrees of differentiation and different tumor sites were detected. The difference between the two groups was not statistically significant (P>0.05). The survival rate analysis showed that the 3-year cumulative survival rate of patients with CTCs positive group was 19.10%, which was lower than that of the negative group (45.20%) (P<0.05). The median survival time was 28.0 months in the CTCs positive group and 35.0 months in the negative group (P<0.05). 【Conclusion】Detection of CTCs positive cells in peripheral blood of patients with colon cancer has certain guiding significance for disease assessment and prognosis.

Key words： Colonic Neoplasms/PA Neoplastic Cells, Circulating/BL Prognosis

收稿日期: 2020-08-17

PACS:

R735.35

通讯作者: E-mail:805672034@qq.com

引用本文:

胡佐宇, 崔正旅, 冯伟. 外周血中循环肿瘤细胞与结肠癌患者进展及预后的相关性研究[J]. 医学临床研究, 2020, 37(11): 1681-1683.
HU Zuo-yu, CUI Zheng-lyu, FENG Wei. Relationship of Peripheral Blood CTCs with Development and Prognosis of Colon Cancer. JOURNAL OF CLINICAL RESEARCH, 2020, 37(11): 1681-1683.

链接本文:

http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2020.11.025 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2020/V37/I11/1681

[1] 李季,夏群,马静. 结肠癌根治术前 CEA 、NLR 水平与患者预后的相关性分析[J].医学临床研究,2020,37(5):781-783.
[2] 白东晓, 杨海军. 循环肿瘤细胞检测与结直肠癌复发转移的研究进展[J].中国肿瘤临床, 2017, 44(3):142-145.
[3] 张艳红, 段春芳, 谢凭. 循环肿瘤细胞对结直肠癌预后的相关性研究[J].河北医药, 2017, 39(11):1634-1637.
[4] Eliasova P, Pinkas M, Kolostova K, et al. Circulating tumor cells in different stages of colorectal cancer[J].Folia Histochem Cytobiol,2017, 55(1):1-5.
[5] 杨平, 魏建昌, 张通,等. 外周血循环肿瘤细胞检测在结直肠癌转移早期诊断中的应用[J].中国医师进修杂志, 2017, 40(8):735-737.
[6] 汪栋, 杨盈赤, 姚宏伟,等. 结直肠癌患者外周血循环肿瘤细胞检测的临床意义[J].中华外科杂志, 2017, 55(10):765-769.
[7] 姚月娟, 荆结线. 结直肠癌循环肿瘤细胞检测的临床价值[J].肿瘤研究与临床, 2017, 29(1):11-14.
[8] Kurzawazegota M, Sharma V, Najafzadeh M, et al. Titanium dioxide nanoparticles induce DNA damage in peripheral blood lymphocytes from polyposis coli, colon cancer patients and healthy individuals: an ex vivo/in vitro study[J].J Nanosci Nanotechnol,2017, 17(12):9274-9285.
[9] 吕国庆, 叶德敬, 刘超英,等. 循环肿瘤细胞检测对直肠癌同步放化疗的临床意义[J].中国肿瘤临床与康复, 2017(3):284-287.
[10] 许扬梅, 龚福生, 陈路川, 等.直肠癌循环肿瘤细胞与原发肿瘤组织基因表达谱的差异分析[J].中国肿瘤生物治疗杂志, 2017, 24(4):348-354.
[11] 蒋文,王礼学,丁怀银. 循环肿瘤细胞监测在结直肠癌肝转移微波消融治疗中临床价值的评估[J].临床肿瘤学杂志, 2018, 23(10):67-72.
[12] Chen C J, Sung W W, Chen H C, et al. Early assessment of colorectal cancer by quantifying circulating tumor cells in peripheral blood: ECT2 in diagnosis of colorectal cancer[J].Int J Mol Sci,2017,18(4):743-745.
[13] Economopoulou P, Georgoulias V, Kotsakis A. Classifying circulating tumor cells to monitor cancer progression[J].Expert Rev Mol Diagn,2017, 17(2):153-165.