血清氨基酸与CEA及CA19-9对结直肠良恶性占位性病变的诊断价值

doi:10.3969/j.issn.1671-7171.2020.08.008

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摘要【目的】探讨血清氨基酸与癌胚抗原(CEA)和糖类抗原(CA19-9)对结直肠良恶性占位性病变的鉴别诊断效果。【方法】于本院接受治疗的94例结直肠占位性病变患者均接受结肠镜取活组织做病理检查,根据检查结果分为两组,对照组为良性病灶患者,共63例,观察组为恶性病灶者,共31例,比较两组患者的基本临床资料以及血清氨基酸、CEA和CA19-9水平,对比较有统计学意义的指标行多因素logistic分析,探究结直肠恶性占位性病变的危险因素。【结果】观察组瓜氨酸、乙醇胺、CEA以及CA19-9水平高于对照组,缬氨酸、5-羟色胺、亮氨酸水平低于对照组,且差异均有显著性(P<0.05);多因素logistic分析显示,瓜氨酸升高、乙醇胺升高、缬氨酸降低、5-羟色胺降低、亮氨酸降低、CEA升高、CA19-9升高是结直肠恶性占位性病变的危险因素。【结论】血清氨基酸与CEA、CA19-9对鉴别诊断结直肠良恶性占位性病变具有重要意义,瓜氨酸、乙醇胺、血清CEA、CA19-9水平升高,缬氨酸、5-羟色胺、亮氨酸水平降低是结直肠恶性占位性病变的危险因素。

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	梅浩砚
	牛惠惠

关键词 ：结直肠肿瘤/诊断, 氨基酸类/血液, 癌胚抗原/血液, 抗原, 肿瘤相关, 碳水化合物/血液

Abstract：【Objective】 To explore the application of serum amino acid, CEA and CA19-9 on the differential diagnosis of benign and malignant colorectal space-occupying lesions. 【Methods】 A total of 94 patients with colorectal space-occupying lesions treated in our hospital were selected. According to the examination results, patients were divided into two groups: the control group with benign lesions (n=63) and the observation group with malignant lesions (n=31). The basic clinical data, serum amino acid, CEA and CA19-9 levels were compared between the two groups. Statistically significant indicators were evaluated by multi-factor logistic analysis to explore the risk factors of malignant colorectal space-occupying lesions. 【Results】 The levels of citrulline, ethanolamine, serum carcinoembryonic antigen (CEA) and carbohydrate antigen (CA19-9) in the observation group were higher than those in the control group, while the levels of valine, serotonin and leucine were lower than the control group, and the differences were statistically significant (P <0.05). Multivariate logistic analysis showed that elevated citrulline, elevated ethanolamine, lowered valine, lowered serotonin, lowered leucine, elevated CEA, and elevated CA19-9 were the risk factors for colorectal malignant mass lesions. 【Conclusion】 Serum amino acids and CEA/CA19-9 are of great significance for the differential diagnosis of colorectal benign and malignant space-occupying lesions. The increased levels of citrulline, ethanolamine, CEA and CA19-9 and the decreased levels of valine, serotonin and leucine in patients may have the risk for colorectal malignant space-occupying lesions.

Key words： Colorectal Neoplasms/DI Amino Acids/BL Carcinoembryonic Antigen/BL Antigens, Tumor-Associated, Carbohydrate/BL

收稿日期: 2019-05-06

PACS:

R735.3

基金资助:湖北省自然科学基金计划项目(2014CDC049)

引用本文:

梅浩砚, 牛惠惠. 血清氨基酸与CEA及CA19-9对结直肠良恶性占位性病变的诊断价值[J]. 医学临床研究, 2020, 37(8): 1145-1147.
MEI Hao-yan, NIU Hui-hui. Diagnostic Value of Serum Amino Acid, CEA and CA19-9 in Benign and Malignant Colorectal Space-occupying Lesions. JOURNAL OF CLINICAL RESEARCH, 2020, 37(8): 1145-1147.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2020.08.008 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2020/V37/I8/1145