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Quick Search     Adv Search 2026 Vol. 43, No. 6 Published: 2026-06-26 Original Articles          Original Articles 881 Analysis of Clinical Characteristics of Drug-Resistant Severe Mycoplasma Pneumoniae Pneumonia in Children of Different Age Groups SUN Hui, HUANG Han, DING Xiaofang, PENG Li, YU Jingwen DOI: 10.3969/j.issn.1671-7171.2026.06.001 【Objective】 To analyze the clinical characteristics of drug-resistant severe Mycoplasma pneumoniae pneumonia (MPP) in children of different age groups. 【Methods】 A retrospective analysis was performed on the clinical data of 207 children diagnosed with drug-resistant severe MPP admitted to The First Affiliated Hospital of Hunan Normal University (Hunan Provincial People's Hospital) from August 2023 to April 2024. The enrolled children were divided into three groups according to age: infant group (age<3 years old, n=40), preschool group (age 3-6 years old, n=73) and school-age group (age>6 years old, n=94). The clinical characteristics were compared among the three groups. 【Results】 Fever and cough were the main clinical manifestations in all children. The infant group had a significantly higher incidence of wheezing (32.50%) and single viral or bacterial co-infection rate (60.00%) than the other two groups, with single viral infection (40.00%) as the predominant complication. The levels of serum C-reactive protein, neutrophil-to-lymphocyte ratio and lactate dehydrogenase in the preschool and school-age groups were significantly higher than those in the infant group (P<0.05). The median D-dimer level of the three groups showed no obvious elevation compared with the normal range (P>0.05), while significantly increased D-dimer level (median: 25.72 mg/L) was observed in 5 children complicated with pulmonary embolism. Massive pulmonary consolidation was the main imaging feature in all groups, especially in the preschool and school-age groups, which also had a higher proportion of pleural effusion than the infant group (P<0.05). All 5 cases of pulmonary embolism occurred in preschool and school-age children. Extrapulmonary complications occurred in 99 children (47.83%), mainly including liver dysfunction and myocardial injury, with a higher incidence in the infant group. One school-age child developed multi-site vascular embolism and achieved a good prognosis after treatment. The school-age group had higher proportions of children receiving tetracycline antibiotics and undergoing bronchoscopic lavage for no less than twice (P<0.05). A total of 28 children (13.53%) received immune supportive therapy, most of whom were from the infant and school-age groups (23/28). All children improved and were discharged after treatment. 【Conclusion】 There are significant differences in clinical characteristics of children with drug-resistant severe MPP across different age groups. Clinically, individualized diagnosis and treatment strategies should be optimized based on age stratification characteristics to improve the efficacy of clinical treatment. 2026 Vol. 43 (6): 881-884 [Abstract] ( 14 ) HTML (1 KB)  PDF (1279 KB)  ( 7 ) 885 Effect of Shanghai-Style Pediatric Tuina Combined with Conventional Chinese Medicine Nursing on Functional Constipation in Children CHEN Huiqing, WU Jialian, SHEN Yijing, YU Yang DOI: 10.3969/j.issn.1671-7171.2026.06.002 【Objective】 To investigate the effect of Shanghai-style pediatric Tuina (Chinese therapeutic massage) combined with conventional Chinese medicine nursing on functional constipation in children. 【Methods】 A total of 100 children under 6 years old with functional constipation admitted to our hospital from April 2023 to December 2024 were selected. They were randomly divided into a control group and an observation group using a random number table method, with 50 cases in each group. The control group received conventional Chinese medicine nursing intervention, while the observation group received Shanghai-style pediatric Tuina in addition to the intervention given to the control group. The clinical efficacy, traditional Chinese medicine (TCM) main symptom scores, bowel sound frequency, and adverse reactions were compared between the two groups. 【Results】 The total effective rate in the observation group was 88.00% (44/50), which was higher than that in the control group (66.00%, 33/50), and the difference was statistically significant (χ2=6.832, P<0.05). After intervention, the TCM main symptom scores of both groups were lower than those before intervention, and the bowel sound frequency was higher than that before intervention. Moreover, the observation group had a lower TCM main symptom score and higher bowel sound frequency compared to the control group, with statistically significant differences (all P<0.05). There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】 Shanghai-style pediatric Tuina combined with conventional Chinese medicine nursing can improve the clinical symptoms of children with functional constipation, promote the recovery of intestinal peristalsis, and has good safety. It is worthy of promotion and application in community health service institutions. 2026 Vol. 43 (6): 885-888 [Abstract] ( 13 ) HTML (1 KB)  PDF (1212 KB)  ( 5 ) 889 Effect of External Application of Traditional Chinese Medicine Combined with Erxian Decoction in the Treatment of Hashimoto's Thyroiditis with Nodules WU Tianxin, XUE Jinhua, YANG Yanqing, GU Jiayin, ZHANG Xiao DOI: 10.3969/j.issn.1671-7171.2026.06.003 【Objective】 To investigate the clinical efficacy of external application of traditional Chinese medicine combined with Erxian Decoction in the treatment of patients with Hashimoto's thyroiditis (HT) accompanied by nodules (phlegm stagnation and blood stasis syndrome). 【Methods】 A total of 196 patients with HT accompanied by nodules (phlegm stagnation and blood stasis syndrome) admitted from June 2022 to December 2024 were enrolled and randomly divided into a control group and an observation group, with 98 cases in each group. The control group was treated with Erxian Decoction alone, while the observation group received Erxian Decoction combined with external application of traditional Chinese medicine. The traditional Chinese medicine (TCM) syndrome scores, thyroid function, antibody levels, and the maximum transverse diameter of thyroid nodules were compared between the two groups before and after treatment. 【Results】 Before treatment, there were no statistically significant differences in all observed indicators between the two groups (all P>0.05). After treatment, the TCM syndrome scores in the observation group were significantly lower than those in the control group (all P<0.05). The levels of thyroid-stimulating hormone (TSH) and free thyroxine (FT4) in the observation group were significantly higher than those in the control group (all P<0.05), while the levels of thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb) were significantly lower than those in the control group (all P<0.05). The maximum transverse diameter of thyroid nodules in both groups decreased compared with before treatment, and the maximum transverse diameter in the observation group was significantly smaller than that in the control group (P<0.05). 【Conclusion】 The combination of Erxian Decoction and external application of traditional Chinese medicine can effectively improve TCM syndrome manifestations in patients with HT accompanied by nodules, regulate thyroid function, reduce thyroid-related antibody levels, and shrink thyroid nodules. The clinical efficacy is significant and worthy of further promotion in clinical practice. 2026 Vol. 43 (6): 889-892 [Abstract] ( 13 ) HTML (1 KB)  PDF (1213 KB)  ( 4 ) 893 Analysis of Bone Flap Absorption after Autologous Skull Repair WANG Jikai, FANG Zhen, ZENG Jia, ZHANG Zichen, KONG Fangen DOI: 10.3969/j.issn.1671-7171.2026.06.004 【Objective】 To investigate the bone flap absorption after autologous skull repair. 【Methods】 A total of 14 patients who underwent autologous skull repair in our hospital from January 2020 to December 2023 were enrolled in this study. Two patients were excluded due to missing imaging data, and a total of 12 patients were finally included. The skull volume on CT images was delineated and automatically calculated by computer software, and the Oulu Resorption Scale (ORS) was adopted to evaluate the degree of bone flap absorption. 【Results】 All patients received complete large integral bone flaps. The skull defect area after craniectomy was (114.23±27.19) cm2, and the bone flap volume was (56.09±14.67) cm3. The operation duration of decompressive craniectomy was (162.83±52.72) min, the duration of skull repair surgery was (189.67±53.19) min, and the interval between the two operations was (130.75±67.11) days. Bone flap absorption occurred in all patients after surgery with varying degrees. The average bone flap volume within 3 months after surgery decreased to 84.12% (45.05%-99.89%) of the original volume, while the average volume decreased to 74.75% (35.45%-96.88%) of the original volume after 3 months postoperatively. The ORS scores were 2.08 (0-7) and 3.83 (0-8) within 3 months and after 3 months after surgery, respectively. 【Conclusion】 Bone flap absorption can occur in some patients after autologous skull repair, and the absorption degree is more severe after 3 months postoperatively than that within 3 months after surgery. 2026 Vol. 43 (6): 893-895 [Abstract] ( 11 ) HTML (1 KB)  PDF (1663 KB)  ( 4 ) 896 Application Effect of Nutritional Nursing Program in Patients with Pulmonary Tuberculosis WANG Zhixia, GAO Xian DOI: 10.3969/j.issn.1671-7171.2026.06.005 【Objective】 To explore the application effect of nutritional nursing program in patients with pulmonary tuberculosis. 【Methods】 A total of 90 inpatients diagnosed with pulmonary tuberculosis admitted to our hospital from November 2021 to October 2024 were selected and divided into a control group (receiving routine intervention) and an observation group (receiving nutritional nursing program on the basis of routine intervention) by random number table method, with 45 cases in each group. The nutritional health behaviors, quality of life and nutritional indicators of the two groups were compared at admission and 3 months after intervention. 【Results】 After 3 months of intervention, the scores of nutritional health behavior, quality of life and levels of nutritional indicators in both groups were higher than those at admission (P<0.05). And the above indicators in the observation group were significantly higher than those in the control group (P<0.05). 【Conclusion】 The nutritional nursing program achieves remarkable effect when applied to patients with pulmonary tuberculosis. It can obviously improve patients' nutritional status, accelerate recovery and elevate their quality of life, which is worthy of clinical promotion and application. 2026 Vol. 43 (6): 896-899 [Abstract] ( 9 ) HTML (1 KB)  PDF (1220 KB)  ( 4 ) 900 Clinical Efficacy of Platelet-Rich Plasma Combined with Closed Reduction and Cannulated Screw Internal Fixation in the Treatment of Femoral Neck Fractures WU Hongliang, DAI Minghua, TENG Yue, CHEN Guocheng, ZHANG Guibao, GUO Yanren DOI: 10.3969/j.issn.1671-7171.2026.06.006 【Objective】 To explore the clinical efficacy of platelet-rich plasma (PRP) combined with closed reduction and cannulated screw internal fixation in the treatment of patients with femoral neck fractures. 【Methods】 A retrospective analysis was performed on 96 patients with femoral neck fractures admitted to Punan Hospital of Pudong New Area from April 2021 to April 2024. The patients were divided into the observation group and the control group according to different treatment methods, with 48 cases in each group. The control group was treated with simple closed reduction and cannulated screw internal fixation, while the observation group received additional PRP treatment on the basis of the control group. The operation-related indicators, hip joint function (Harris Hip Score), excellent and good rate of hip joint function, and incidence of complications were compared between the two groups. 【Results】 The fracture healing time and hospital stay in the observation group were significantly shorter than those in the control group (P<0.05). At 6 and 12 months after surgery, the Harris scores and the excellent and good rate of hip joint function of the observation group were higher than those of the control group (P<0.05). The total incidence of complications in the observation group was lower than that in the control group (P<0.05). 【Conclusion】 PRP combined with closed reduction and cannulated screw internal fixation has definite curative effect in the treatment of femoral neck fractures, which can promote fracture healing, improve hip joint function and reduce the incidence of complications. 2026 Vol. 43 (6): 900-902 [Abstract] ( 8 ) HTML (1 KB)  PDF (1246 KB)  ( 4 ) 903 Efficacy of Guanxinning Injection Combined with Sacubitril/Valsartan in the Treatment of Coronary Heart Disease with Congestive Heart Failure and Effect on Cardiac Function and Myocardial Injury Markers ZHANG Xiaorui, LI Jianhua, LIU Hui DOI: 10.3969/j.issn.1671-7171.2026.06.007 【Objective】 To investigate the clinical efficacy of Guanxinning Injection combined with Sacubitril/Valsartan in the treatment of coronary heart disease complicated with congestive heart failure and its effects on cardiac function and myocardial injury markers. 【Methods】 A total of 110 patients with coronary heart disease complicated with congestive heart failure admitted to two hospitals from July 2024 to June 2025 were enrolled. The patients were randomly divided into an observation group and a control group using a random number table method, with 55 cases in each group. The control group received Sacubitril/Valsartan on the basis of conventional treatment, while the observation group received Guanxinning Injection in addition to the treatment of the control group. The clinical efficacy, cardiac function indicators [left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD)], myocardial injury markers [N-terminal pro-brain natriuretic peptide (NT-proBNP), cardiac troponin T (cTnT), cardiac troponin I (cTnI)], and the incidence of adverse reactions were compared between the two groups. 【Results】 The total clinical effective rate in the observation group was 96.36%(53/55), which was higher than that in the control group [85.45%(47/55)], and the difference was statistically significant (χ2=3.960, P<0.05). After treatment, LVEF in both groups was higher than that before treatment, while LVEDD and LVESD were shorter than those before treatment; The observation group showed higher LVEF and shorter LVEDD and LVESD compared with the control group, with statistically significant differences (P<0.05). After treatment, the serum levels of NT-proBNP, cTnT, and cTnI in both groups were lower than those before treatment, and these levels in the observation group were lower than those in the control group, with statistically significant differences (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (χ2=0.909, P>0.05). 【Conclusion】 The combination of Guanxinning injection and sacubitril/valsartan demonstrates favorable efficacy in patients with coronary heart disease and congestive heart failure by improving cardiac function and reducing myocardial injury, without increasing adverse reactions. 2026 Vol. 43 (6): 903-906 [Abstract] ( 19 ) HTML (1 KB)  PDF (1216 KB)  ( 4 ) 907 Clinical Efficacy of Traditional Chinese Medicine Acupoint Application Combined with Auricular Point Pressing in the Treatment of Preschool Children with Allergic Rhinitis SONG Yunfeng, ZHAO Xiang, WANG Shulan DOI: 10.3969/j.issn.1671-7171.2026.06.008 【Objective】 To explore the clinical efficacy of traditional Chinese medicine (TCM) acupoint application combined with auricular point pressing in the treatment of preschool children with allergic rhinitis (AR). 【Methods】 A total of 90 preschool children with AR treated in our hospital from May 2022 to May 2025 were selected and divided into the acupoint application group, auricular point pressing group and combined group by random number table method, with 30 cases in each group. All children received basic treatment and routine nursing. On this basis, the acupoint application group was treated with TCM acupoint application, the auricular point pressing group was treated with auricular point pressing therapy, and the combined group received combined treatment of TCM acupoint application and auricular point pressing. The TCM symptom scores, clinical efficacy, emergency western medicine use score and quality of life score were compared among the three groups before and after intervention. 【Results】 After 6 months of intervention, the TCM symptom scores of the three groups were lower than those before intervention, and the combined group had significantly lower scores than the other two groups (P<0.05). The total clinical effective rate of the combined group was 96.67%, which was higher than 73.33% of the acupoint application group and 60.00% of the auricular point pressing group (P<0.05). After intervention, the emergency western medicine use score of the combined group was lower than that of the other two groups (P<0.05). Additionally, each dimension score and total score of quality of life in the combined group were significantly lower than those in the acupoint application group and auricular point pressing group (P<0.05). 【Conclusion】 For preschool children with AR, TCM acupoint application combined with auricular point pressing can improve TCM symptoms, increase the total clinical effective rate, reduce the dosage of emergency western medicine, and optimize children's quality of life, which has good clinical application value. 2026 Vol. 43 (6): 907-909 [Abstract] ( 9 ) HTML (1 KB)  PDF (1252 KB)  ( 4 ) 910 Construction of a Machine Learning-Based Diagnostic Model Using Routine Blood Parameters for Identification of Mycoplasma Pneumoniae Infection CHEN Yue, XIAO Chunhai DOI: 10.3969/j.issn.1671-7171.2026.06.009 【Objective】 To explore the application of routine blood parameters in establishing machine learning screening models to construct and validate a nomogram diagnostic model for mycoplasma pneumoniae (MP) infection based on hematological indicators. 【Methods】 Clinical data from 4823 patients who underwent MP antigen testing and routine blood examinations at our hospital between January 2024 and June 2025 were retrospectively analyzed. Among them, 2545 MP-positive patients were assigned to the infection group, while 2278 MP-negative patients served as the control group. Four machine learning models, including Logistic regression, random forest, decision tree, and neural network, were established. Receiver operating characteristic (ROC) curves were used to compare the area under the curve (AUC) values of the four models. 【Results】 The AUC values of the Logistic regression, random forest, decision tree, and neural network models were 0.952, 0.942, 0.860, and 0.819, respectively. Multivariate analysis of the optimal Logistic regression model showed that variables with statistical significance (P<0.05) included age, red blood cell (RBC) count, red blood cell distribution width coefficient of variation (RDW-CV), mean platelet volume (MPV), mean corpuscular hemoglobin concentration (MCHC), and platelet (PLT) count. Based on the multivariate analysis results, a nomogram diagnostic model for MP infection using routine blood parameters was established along with clinical decision and clinical impact curves. 【Conclusion】 The Logistic regression and nomogram models that were constructed based on age, RBC count, RDW-CV, MPV, MCHC, and PLT count can effectively assist in the diagnosis of MP infection and demonstrate important clinical application value. 2026 Vol. 43 (6): 910-913 [Abstract] ( 12 ) HTML (1 KB)  PDF (1508 KB)  ( 4 ) 914 Analysis of Parenting Stress and its Influencing Factors among Mothers of Preterm Infants at 1 Year Corrected Age SHI Junxia, LIN Lin DOI: 10.3969/j.issn.1671-7171.2026.06.010 【Objective】 To explore the current status and influencing factors of parenting stress among mothers of preterm infants at 1 year corrected age. 【Methods】 A total of 500 preterm infants at 1 year corrected age and their mothers who received follow-up in the high-risk infant clinic of our hospital from January 2024 to December 2025 were enrolled by random sampling method. The Parenting Stress Index-Short Form (PSI-SF), Maternal and Child Feeding Difficulty Scale (MCH-FS), Brief Infant Sleep Questionnaire (BISQ), and Neuropsychological Development Scale for Children Aged 0-6 Years were adopted for investigation. Parenting stress scores of mothers with different basic characteristics were compared, and multiple linear regression analysis was performed to analyze the influencing factors of parenting stress among mothers of preterm infants at 1 year corrected age. 【Results】 Significant differences were found in parental distress (PD), parent-child dysfunctional interaction (P-CDI), difficult child (DC) scores and total PSI-SF scores among mothers with different educational levels, annual family incomes, numbers of children, previous adverse pregnancy histories and quantities of gestational complications (P<0.05). Similarly, the above scores differed significantly in groups stratified by infants' small for gestational age status, birth weight, neonatal complications, twin pregnancy/multiple pregnancy status and in vitro fertilization conception status (P<0.05). In addition, statistically significant differences existed in PD, P-CDI, DC and total PSI-SF scores among mothers of infants with different developmental quotient (DQ) at 1 year corrected age, sleep regularity, falling-asleep difficulty, sleep disorders and feeding difficulty degrees (P<0.05). Multiple linear regression analysis showed that infant sleep difficulty, irregular sleep, feeding difficulty, developmental quotient, number of neonatal complications, number of children in the family and twin pregnancy were independent influencing factors for maternal parenting stress (P<0.05). 【Conclusion】 Parenting stress among mothers of preterm infants at 1 year corrected age is affected by multiple factors. In high-risk infant management, medical staff should attach great importance to the screening and intervention of infant sleep and feeding problems, and provide targeted psychosocial support for families with high-risk characteristics, so as to promote maternal and infant health. 2026 Vol. 43 (6): 914-917 [Abstract] ( 12 ) HTML (1 KB)  PDF (1277 KB)  ( 4 ) 918 Application Effect of CO2 Fractional Laser Combined with Subcutaneous Dissection Followed by Concentrated Growth Factor Filling in the Treatment of Depressed Scars PENG Cheng, MING Haixia, LI Dailing, ZHANG Xinjie, LI Xiaoping DOI: 10.3969/j.issn.1671-7171.2026.06.011 【Objective】 To explore the application effect of CO2 fractional laser combined with subcutaneous dissection followed by concentrated growth factor (CGF) filling in the treatment of depressed scars. 【Methods】 A total of 100 patients with depressed scars treated in our hospital from July 2023 to June 2025 were enrolled and divided into the control group and the observation group according to different treatment methods, with 50 cases in each group. The control group was treated with CO2 fractional laser alone, while the observation group received combined treatment of CO2 fractional laser, subcutaneous dissection and subsequent CGF filling. The two groups were compared in terms of scar grading, pain score, anxiety score, scar satisfaction score, Global Aesthetic Improvement Scale (GAIS) score, duration of erythema and edema, healing time, and incidence of pigmentation. 【Results】 After treatment, the scar grading of the observation group was lower than that of the control group (P<0.05). At 1 and 3 days after treatment, the Visual Analogue Scale (VAS) scores of the observation group were higher than those of the control group (P<0.05); there was no significant difference in VAS scores between the two groups at 7 days after treatment (P>0.05). After treatment, the Self-Rating Anxiety Scale (SAS) score of the observation group was lower than that of the control group, while the scar satisfaction score and GAIS score were higher (P<0.05). No significant differences were found in the duration of erythema and edema, healing time and incidence of pigmentation between the two groups (P>0.05). 【Conclusion】 For patients with depressed scars, the combined regimen of CO2 fractional laser, subcutaneous dissection and CGF filling can effectively improve the morphological appearance of scar lesions, enhance the overall aesthetic effect, and relieve appearance-related anxiety. Although patients experience obvious short-term postoperative pain, they can achieve good long-term comfort. 2026 Vol. 43 (6): 918-921 [Abstract] ( 9 ) HTML (1 KB)  PDF (1215 KB)  ( 4 ) 922 Effects of Smoking Cessation CBT Combined with rTMS on Clinical Symptoms and Nicotine Dependence in Schizophrenia Patients with Tobacco Dependence LIU Yan DOI: 10.3969/j.issn.1671-7171.2026.06.012 【Objective】 To explore the effects of smoking cessation cognitive behavioral therapy (CBT) combined with repetitive transcranial magnetic stimulation (rTMS) on clinical symptoms and nicotine dependence in schizophrenia patients with tobacco dependence. 【Methods】 A total of 100 schizophrenia patients complicated with tobacco dependence admitted to the psychiatry department of our hospital from January 2023 to December 2024 were enrolled and divided into control group and observation group by random number table method, with 50 cases in each group. The control group received rTMS combined with original antipsychotic drugs; the observation group was additionally given smoking cessation CBT on the basis of the regimen for the control group. The clinical symptoms [Positive and Negative Syndrome Scale (PANSS) score], nicotine dependence level [Fagerstrom Test for Nicotine Dependence (FTND) score], smoking craving [Brief Questionnaire of Smoking Urges (QSU-Brief)], blood carboxyhemoglobin (COHb) and urinary cotinine levels before and after intervention were compared between the two groups, and adverse events were recorded. 【Results】 After intervention, the scores of positive symptoms, negative symptoms, and general psychopathology in both groups were lower than those before intervention, and the observation group was lower than the control group, with statistically significant differences (P<0.05). The FTND and QSU-Brief scores in both groups were lower than those before intervention, and the observation group was lower than the control group, with statistically significant differences (P<0.05). The levels of COHb and urinary cotinine in both groups were lower than those before intervention, and the observation group was lower than the control group, with statistically significant differences (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (χ2=0.045, P>0.05). 【Conclusion】 On the basis of conventional antipsychotic treatment, smoking cessation CBT combined with rTMS can remarkably alleviate tobacco dependence and smoking craving, improve psychiatric symptoms in schizophrenia patients with tobacco dependence with satisfactory safety, which possesses promising clinical application value. 2026 Vol. 43 (6): 922-925 [Abstract] ( 9 ) HTML (1 KB)  PDF (1207 KB)  ( 4 ) 926 Effects of Traditional Chinese Medicine Cardiac Rehabilitation Exercise Combined with Respiratory Function Training on Oxygenation, Cardiopulmonary Function, Exercise Capacity and Quality of Life in Coronary Heart Disease Patients after PCI SHEN Yanan, ZHAO Feiran, FENG Ling DOI: 10.3969/j.issn.1671-7171.2026.06.013 【Objective】 To explore the effects of traditional Chinese medicine (TCM) cardiac rehabilitation exercise combined with respiratory function training on oxygenation function, cardiopulmonary function, exercise capacity and quality of life in patients with coronary heart disease (CHD) after percutaneous coronary intervention (PCI). 【Methods】 A total of 120 CHD patients after PCI admitted to our hospital from April 2023 to April 2025 were enrolled and randomly divided into the observation group (receiving TCM cardiac rehabilitation exercise combined with respiratory function training) and the control group (receiving respiratory function training alone), with 60 cases in each group. The oxygenation function [maximal oxygen uptake (VO2max), peak rate of perceived exertion (PREspk), peak metabolic equivalent (METspk)], cardiopulmonary function [right ventricular end-diastolic diameter (RVEDD), right ventricular anterior wall thickness (RVAWT), pulmonary artery systolic pressure (PASP), forced expiratory volume in the first second (FEV1), forced vital capacity (FVC), FEV1/FVC], exercise capacity [6-minute walking distance (6MWD), maximal exercise load], and quality of life [Chinese Cardiovascular Quality of Life Questionnaire (CQQC) score] were compared between the two groups. 【Results】 After treatment, VO2max and METspk increased while PREspk decreased in both groups; the observation group had higher VO2max and METspk, and lower PREspk than the control group (all P<0.05). In terms of cardiopulmonary function, RVEDD, RVAWT and PASP decreased, while FEV1, FVC and FEV1/FVC increased in both groups after treatment; the observation group presented lower RVEDD, RVAWT, PASP and higher FEV1, FVC, FEV1/FVC (all P<0.05). Additionally, 6MWD and maximal exercise load of both groups were significantly improved after treatment, with better outcomes in the observation group (P<0.05). All dimension scores of CQQC in the observation group were higher than those in the control group after intervention (P<0.05). 【Conclusion】 TCM cardiac rehabilitation exercise combined with respiratory function training can effectively improve oxygenation function, cardiopulmonary function and exercise capacity, and enhance the quality of life of CHD patients after PCI, which plays a positive role in promoting postoperative rehabilitation. 2026 Vol. 43 (6): 926-929 [Abstract] ( 16 ) HTML (1 KB)  PDF (1280 KB)  ( 4 ) 930 Construction of an Invasiveness Assessment System for Lung Adenocarcinoma Based on Triple Markers of CD34, α-SMA, and β-Tubulin-Ⅲ and its Clinical Significance CAI Lin, LIN Yong DOI: 10.3969/j.issn.1671-7171.2026.06.014 【Objective】 To investigate the value of the combined detection of CD34, α-smooth muscle actin (α-SMA), and β-Ⅲ tubulin (β-Tubulin-Ⅲ) immunostaining for assessing invasiveness in lung adenocarcinoma. 【Methods】 We retrospectively analyzed 100 resected lung adenocarcinomas, including 15 adenocarcinoma in situ (AIS), 35 minimally invasive adenocarcinomas (MIA), and 50 invasive adenocarcinomas (IA). The CD34, α-SMA, and β-Tubulin-Ⅲ expressions were evaluated by immunohistochemistry and correlated with clinicopathological findings and follow-up data. 【Results】 AIS, MIA, and lepidic-predominant IA mainly showed a "double-track" pattern, which was characterized by reticular CD34 positivity and linear α-SMA staining along the basement membrane. In contrast, acinar- and solid-predominant IA showed a "loss-and-gain" pattern, which exhibited the loss of CD34 expression and strong stromal α-SMA positivity, whereas papillary-predominant IA showed an irregular linear pattern. β-Tubulin-Ⅲ was negative in AIS and most lepidic areas, but its expression was significantly upregulated in IA and correlated with invasive extent (all P<0.05). Follow-up data demonstrated favorable outcomes in AIS/MIA, most of whom underwent sublobar resection. Recurrence/metastasis-free survival did not have statistical significance between lepidic-predominant IA and AIS/MIA groups (P>0.05), whereas the risk of recurrence or metastasis in other types of IA was significantly higher than that in the AIS/MIA group and the lepidic-predominant IA group (P<0.05). 【Conclusion】 The combined detection of CD34, α-SMA, and β-Tubulin-Ⅲ aids in improving the accuracy of determining true invasion in lung adenocarcinoma, thereby providing a pathological basis for sublobar resection strategies in AIS/MIA and for individualized surgical decision-making in invasive adenocarcinomas. 2026 Vol. 43 (6): 930-934 [Abstract] ( 10 ) HTML (1 KB)  PDF (2786 KB)  ( 4 ) 935 Analysis of Color Doppler Ultrasound Imaging Features and its Diagnostic Value in Urinary System Calculi XU Xiaozhen, ZHANG Chuanchuan DOI: 10.3969/j.issn.1671-7171.2026.06.015 【Objective】 To explore the imaging features of urinary system calculi by color Doppler ultrasound and analyze its clinical diagnostic value. 【Methods】 A retrospective analysis was conducted on the clinical data of 80 patients with urinary system calculi admitted to two hospitals from September 2021 to September 2025. All patients underwent preoperative two-dimensional ultrasound and color Doppler ultrasound examination. With surgical exploration or stone discharge after extracorporeal lithotripsy as the gold standard, the stone detection rate and segmental ureteral stone detection results of the two examination methods were compared, and the imaging characteristics of urinary calculi were summarized. 【Results】 Among the enrolled patients, 12 cases were diagnosed with bladder calculi, 31 cases with renal calculi, and 37 cases with ureteral calculi. The detection rates of bladder calculi, renal calculi and ureteral calculi by color Doppler ultrasound were significantly higher than those of two-dimensional ultrasound (all P<0.05). For upper and middle ureteral calculi, color Doppler ultrasound presented superior detection efficiency with statistically significant differences (all P<0.05). There was no significant difference in the detection rate of lower ureteral calculi between two-dimensional ultrasound and color Doppler ultrasound (P>0.05). 【Conclusion】 Color Doppler ultrasound can clearly display the ultrasonic imaging characteristics of different types of urinary system calculi. It has a significantly higher detection rate for bladder calculi, renal calculi, and upper and middle ureteral calculi than two-dimensional ultrasound, possessing important clinical application value. 2026 Vol. 43 (6): 935-937 [Abstract] ( 11 ) HTML (1 KB)  PDF (1190 KB)  ( 4 ) 938 Efficacy of Dapagliflozin Combined with Enalapril in the Treatment of Patients with Diabetic Nephropathy ZHOU Yuanting DOI: 10.3969/j.issn.1671-7171.2026.06.016 【Objective】 To investigate the efficacy of dapagliflozin combined with enalapril in the treatment of patients with diabetic nephropathy (DN). 【Methods】 A total of 93 patients with DN admitted to our hospital from February 2022 to November 2025 were enrolled. According to different treatment methods, they were divided into a control group (n=47, treated with enalapril) and an observation group (n=46, treated with dapagliflozin combined with enalapril). The clinical efficacy of the two groups was compared, as well as blood glucose indices [fasting blood glucose (FPG), glycated hemoglobin (HbA1c)], renal function indices [β2-microglobulin (β2-MG), cystatin C (cys C), homocysteine (Hcy)], inflammatory markers [intercellular adhesion molecule-1 (ICAM-1), serum amyloid A (SAA), interleukin-6 (IL-6)], oxidative stress indices [total antioxidant capacity (TAOC), malondialdehyde (MDA), superoxide dismutase (SOD)], and safety before and after treatment. 【Results】 After treatment, the efficacy in the observation group was higher than that in the control group (P<0.05). The levels of FPG, HbA1c, β2-MG, cys C, Hcy, ICAM-1, SAA, IL-6, and MDA in both groups were lower than those before treatment (P<0.05);Furthermore, those levels in the observation group were lower than those in the control group (P<0.05). The levels of TAOC and SOD in both groups were higher than those before treatment (P<0.05), and both TACO and SOD levels in the observation group were higher than those in the control group (P<0.05). There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】 Dapagliflozin combined with enalapril in the treatment of DN patients can effectively improve clinical efficacy by reducing blood glucose levels, alleviating inflammatory response and oxidative stress, and promoting the recovery of renal function, with good safety. 2026 Vol. 43 (6): 938-940 [Abstract] ( 10 ) HTML (1 KB)  PDF (1256 KB)  ( 4 ) 941 Clinical Effect of Nasal Intermittent Positive Pressure Ventilation in the Treatment of Neonatal Respiratory Distress Syndrome and its Influence on Blood Gas Indexes and Neurodevelopment of Neonates LI Bin DOI: 10.3969/j.issn.1671-7171.2026.06.017 【Objective】 To investigate the clinical effect of nasal intermittent positive pressure ventilation (NIPPV) in the treatment of neonatal respiratory distress syndrome (NRDS) and its influence on blood gas indexes and neurodevelopment of neonates. 【Methods】 A total of 148 neonates with NRDS admitted to our hospital from August 2019 to August 2024 were selected and divided into observation group and control group according to different ventilation regimens, with 74 cases in each group. The observation group was treated with NIPPV mode, while the control group received nasal continuous positive airway pressure (N-CPAP) mode. The treatment outcomes, arterial partial pressure of carbon dioxide (PaCO2), arterial partial pressure of oxygen (PaO2), pH value, oxygenation index (OI) and neurodevelopment status were compared between the two groups. 【Results】 The hospitalization stay and oxygen therapy duration of the observation group were shorter, and the number of apnea episodes was less than those of the control group, with statistically significant differences (P<0.05). After treatment, PaCO2 and OI decreased, while pH value and PaO2 increased in both groups compared with baseline; the observation group had lower PaCO2 and OI, as well as higher pH value and PaO2 than the control group, and all differences were statistically significant (P<0.05). At 12 months after treatment, the proportions of neonates with intelligence scale score ≥85, motor scale score ≥85 and developmental quotient (DQ) ≥85 in the observation group were all higher than those in the control group, with statistically significant differences (P<0.05). The total incidence of adverse reactions in the observation group and control group was 13.51% (10/74) and 14.86% (11/74) respectively, and there was no statistically significant difference between the two groups (χ2=0.055, P>0.05). 【Conclusion】 NIPPV can rapidly improve respiratory function and clinical symptoms, significantly ameliorate oxygenation function and correct hypoxemia in neonates with NRDS, help maintain the body's acid-base balance, and possesses favorable safety. 2026 Vol. 43 (6): 941-944 [Abstract] ( 12 ) HTML (1 KB)  PDF (1217 KB)  ( 4 ) 945 Effects of Citrus Flavone Combined with Diosmin on Perianal Edema, Pain Degree and Clinical Efficacy in Patients with Circular Mixed Hemorrhoids after Surgery SHEN Jianzhong DOI: 10.3969/j.issn.1671-7171.2026.06.018 【Objective】 To explore the effects of citrus flavone combined with diosmin on postoperative perianal edema, pain degree and clinical efficacy in patients with circular mixed hemorrhoids. 【Methods】 A total of 90 patients with circular mixed hemorrhoids admitted to our hospital from February 2022 to February 2025 were selected and divided into the control group and the observation group by random number table method, with 45 cases in each group. The control group received oral diosmin tablets after surgery, while the observation group was treated with oral diosmin tablets combined with citrus flavone tablets after surgery. The perianal edema degree, pain degree and clinical efficacy of the two groups were compared on the 1st and 7th day after operation. 【Results】 On the 7th day after surgery, the perianal edema scores of both groups were lower than those on the 1st day after surgery, and the observation group had significantly lower scores than the control group (P<0.05). Similarly, the Visual Analogue Scale (VAS) scores of the two groups on the 7th day after surgery were lower than those on the 1st day after surgery, and the observation group was superior to the control group (P<0.05). The total clinical effective rate of the observation group was 97.78% (44/45), which was significantly higher than 77.78% (35/45) of the control group (χ2=8.389, P<0.05). 【Conclusion】 The combination of citrus flavone and diosmin can effectively relieve postoperative perianal edema and pain in patients with circular mixed hemorrhoids, with favorable clinical efficacy, which is worthy of clinical promotion and application. 2026 Vol. 43 (6): 945-947 [Abstract] ( 12 ) HTML (1 KB)  PDF (1191 KB)  ( 4 ) 948 Clinical Efficacy of Shensong Yangxin Capsule Combined with Telmisartan Tablets and Metoprolol Tartrate Tablets in the Treatment of Hypertensive Patients Complicated with Arrhythmia FAN Lili DOI: 10.3969/j.issn.1671-7171.2026.06.019 【Objective】 To explore the clinical efficacy of Shensong Yangxin Capsule combined with telmisartan tablets and metoprolol tartrate tablets in the treatment of hypertensive patients complicated with arrhythmia. 【Methods】 A total of 104 hypertensive patients combined with arrhythmia admitted to our hospital from February 2024 to June 2025 were selected and divided into control group and observation group by random number table method, with 52 cases in each group. The control group received telmisartan tablets combined with metoprolol tartrate tablets tartrate, and the observation group was given Shensong Yangxin Capsule on the basis of the treatment for the control group. The two groups were compared in terms of clinical efficacy, blood pressure [diastolic blood pressure (DBP), systolic blood pressure (SBP)], cardiac function indicators [left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), left ventricular ejection fraction (LVEF)] and incidence of adverse reactions. 【Results】 The total clinical effective rate of the observation group was 94.23% (49/52), which was higher than 75.00% (39/52) of the control group, and the difference was statistically significant (χ2=7.386, P<0.05). After treatment, DBP and SBP in both groups were lower than those before treatment, and the levels in the observation group were lower than those in the control group, with statistically significant differences (P<0.05). After treatment, LVEDD and LVESD of the two groups were decreased and LVEF was increased compared with those before treatment; LVEDD and LVESD in the observation group were lower, while LVEF was higher than those in the control group, and all differences had statistical significance (all P<0.05). There was no statistically significant difference in the total incidence of adverse reactions between the two groups (χ2=0.377, P＞0.05). 【Conclusion】 Shensong Yangxin Capsule combined with telmisartan tablets and metoprolol tartrate tablets can obviously improve cardiac function of hypertensive patients complicated with arrhythmia, with good clinical efficacy and high safety. 2026 Vol. 43 (6): 948-950 [Abstract] ( 12 ) HTML (1 KB)  PDF (1254 KB)  ( 4 ) 951 Efficacy of Sintilimab Combined with the SOX Regimen in the Treatment of Advanced Gastric Cancer MA Zihan, GAO Zhan, QIAO Yanjing DOI: 10.3969/j.issn.1671-7171.2026.06.020 【Objective】 To investigate the clinical efficacy of sintilimab combined with the SOX regimen in the treatment of advanced gastric cancer. 【Methods】 A total of 90 patients with advanced gastric cancer admitted to our hospital between June 2021 and June 2025 were randomly divided into a control group (treated with the SOX regimen) and an observation group (treated with sintilimab combined with the SOX regimen), with 45 patients in each group. Immune function indicators, angiogenesis indicators [endostatin (ES), vascular endothelial growth factor (VEGF), and angiopoietin-2 (Ang-2)], tumor markers [carbohydrate antigen 125 (CA125), carbohydrate antigen 19-9 (CA19-9), and carcinoembryonic antigen (CEA)], functional status [Karnofsky Performance Status (KPS) score], activities of daily living [Activities of Daily Living (ADL) score], and adverse reactions were compared between the two groups before and after treatment. 【Results】 After 4 cycles of treatment, the levels of CD3+, CD4+, and CD4+/CD8+ in the observation group were significantly higher than those in the control group, while the CD8+ level was significantly lower than that in the control group (all P<0.05). The ES level of posttreatment in the observation group was significantly higher than that in the control group, whereas VEGF and Ang-2 levels were significantly lower than those in the control group (P<0.05). Levels of CA125, CA19-9, and CEA in the observation group were significantly lower than those in the control group (P<0.05), while KPS and ADL scores were significantly higher than those in the control group (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】 Sintilimab combined with the SOX regimen for advanced gastric cancer can effectively enhance immune function, inhibit tumor angiogenesis, reduce tumor marker levels, and improve quality of life, with good safety. 2026 Vol. 43 (6): 951-954 [Abstract] ( 12 ) HTML (1 KB)  PDF (1215 KB)  ( 4 ) 955 Effect of Outcome-Oriented Intervention Program on Self-Care Ability of Patients with Pelvic Floor Dysfunction PAN Xili DOI: 10.3969/j.issn.1671-7171.2026.06.021 【Objective】 To explore the effect of outcome-oriented intervention program on the self-care ability of patients with pelvic floor dysfunction. 【Methods】 A total of 106 patients with pelvic floor dysfunction admitted to our hospital from January 2021 to December 2023 were selected and divided into the control group (receiving routine intervention) and the observation group (receiving outcome-oriented intervention program) by random number table method, with 53 cases in each group. The total effective rate, urinary incontinence status [International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF) score], self-care ability [Exercise of Self-Care Agency Scale (ESCA) score], and negative emotions [Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) scores] were compared between the two groups. 【Results】 After intervention, the total effective rate of the observation group was 83.02%, which was higher than 66.04% of the control group, and the difference was statistically significant (P<0.05). After intervention, the scores of ICIQ-SF, SAS and SDS in the observation group were lower than those in the control group (P<0.05), and the scores of all dimensions of ESCA were higher than those in the control group (P<0.05). 【Conclusion】 The outcome-oriented nursing program can significantly improve pelvic floor muscle strength, relieve urinary incontinence symptoms, enhance self-care ability, and alleviate negative emotions in patients with pelvic floor dysfunction, which is conducive to improving the overall quality of life of patients. 2026 Vol. 43 (6): 955-957 [Abstract] ( 13 ) HTML (1 KB)  PDF (1248 KB)  ( 4 ) 958 Predictive Value of Gleason Score Combined with Clinicopathological Features for the Prognosis of Patients with Prostate Cancer JIANG Xiufang DOI: 10.3969/j.issn.1671-7171.2026.06.022 【Objective】 To investigate the predictive value of the Gleason score combined with clinicopathological features for the prognosis of patients with prostate cancer. 【Methods】 A total of 98 patients with prostate cancer admitted to our hospital from January 2022 to June 2023 were followed up for 2 years. According to survival outcomes, the patients were divided into a survival group (74 cases) and a death group (24 cases). Clinical characteristics of the two groups were collected and compared. Univariate analysis was performed to screen indicators with significant differences between groups, and multivariate logistic regression analysis was conducted to identify independent risk factors. Receiver operating characteristic (ROC) curves were plotted to evaluate the predictive efficacy of the Gleason score combined with clinicopathological features for patient prognosis. 【Results】 The proportions of patients with TNM stage Ⅲ-Ⅳ prostate cancer, lymph node metastasis, poorly to moderately differentiated tumors, and Gleason scores in the death group were significantly higher than those in the survival group (P<0.05). Multivariate logistic regression analysis showed that TNM stage, lymph node metastasis, and Gleason score were independent risk factors for death in patients with prostate cancer(P<0.05), whereas degree of differentiation was an independent protective factor (P<0.05). The area under the curve (AUC) of the regression model was 0.907, with a sensitivity of 75.0% and a specificity of 91.9%. 【Conclusion】 Gleason score combined with clinicopathological features such as TNM stage and lymph node metastasis has high predictive value for the prognosis of patients with prostate cancer and may serve as an important reference indicator for clinical prognostic evaluation. 2026 Vol. 43 (6): 958-961 [Abstract] ( 9 ) HTML (1 KB)  PDF (1256 KB)  ( 4 ) 962 Clinical Efficacy of Insulin Aspart Combined with Insulin Detemir in the Treatment of Patients with Gestational Diabetes Mellitus YANG Weixiao, LIU Xiaohui, YIN Huanhuan DOI: 10.3969/j.issn.1671-7171.2026.06.023 【Objective】 To explore the clinical efficacy of insulin aspart combined with insulin detemir in the treatment of patients with gestational diabetes mellitus (GDM). 【Methods】 A total of 150 patients with GDM admitted to our hospital from January 2022 to December 2024 were selected and randomly divided into the observation group and the control group at a ratio of 1∶1, with 75 cases in each group. The control group was treated with insulin aspart alone, while the observation group was treated with combined insulin aspart and insulin detemir on the basis of the control group. The clinical efficacy, blood glucose levels [fasting plasma glucose (FPG), 2-hour postprandial blood glucose (2hPG)], islet-related hormone and adipokine levels [C-peptide, visfatin (VF), leptin (LP), adiponectin], islet cell function indicators [fasting insulin (FINS), homeostasis model assessment of β-cell function (HOMA-β)] and homeostasis model assessment of insulin resistance (HOMA-IR) were compared between the two groups. 【Results】 The total clinical effective rate of the observation group was higher than that of the control group (P<0.05). After treatment, the levels of FPG, 2hPG, VF, LP, FINS and HOMA-IR in the observation group were lower than those in the control group (P<0.05), while the levels of C-peptide, adiponectin and HOMA-β were higher (P<0.05). 【Conclusion】 The combination of insulin aspart and insulin detemir can significantly improve the clinical efficacy, optimize blood glucose status, regulate the levels of islet-related hormones and enhance islet cell function in the treatment of GDM. 2026 Vol. 43 (6): 962-964 [Abstract] ( 9 ) HTML (1 KB)  PDF (1249 KB)  ( 4 ) 965 Application Value of Early Oral Motor Therapy Combined with Touch Care in Low Birth Weight Preterm Infants LIU Caihong DOI: 10.3969/j.issn.1671-7171.2026.06.024 【Objective】 To explore the application value of early oral motor therapy combined with touch care in low birth weight preterm infants. 【Methods】 A total of 70 low birth weight preterm infants treated in the Department of Neonatology of our hospital from December 2021 to December 2024 were selected and divided into control group and observation group by random number table method, with 35 cases in each group. Preterm infants in the control group received routine nursing combined with touch care, while the observation group was given additional early oral motor therapy on the basis of the control group, with a 3-week intervention period. The oral motor function [Neonatal Oral-Motor Assessment Scale (NOMAS) score], nutritional status [albumin (ALB), serum prealbumin (PA)] and weight gain of preterm infants in the two groups were compared before nursing and after 3 weeks of nursing. 【Results】 After 3 weeks of intervention, the normal pattern score of NOMAS in the observation group was higher than that in the control group, while the scores of disorder pattern and dysfunction pattern were lower (P<0.05). The levels of ALB and PA in the observation group were significantly higher than those in the control group after 3 weeks of nursing (P<0.05). There was no statistically significant difference in the weight of preterm infants at the initiation of oral feeding between the two groups (P>0.05); the weights of infants in the observation group at full oral feeding and discharge were higher than those in the control group (P<0.05). 【Conclusion】 The combination of early oral motor therapy and touch care applied to low birth weight preterm infants can significantly improve their oral motor function and nutritional status, and promote weight gain of preterm infants. 2026 Vol. 43 (6): 965-968 [Abstract] ( 8 ) HTML (1 KB)  PDF (1210 KB)  ( 5 ) 969 Diagnostic Efficacy of CMR-Based Left Atrial Strain Parameters for Left Ventricular Fibrosis in Patients with Dilated Cardiomyopathy YUAN Shuai, LI Yun DOI: 10.3969/j.issn.1671-7171.2026.06.025 【Objective】 To explore the diagnostic efficacy of cardiac magnetic resonance (CMR)-based left atrial strain parameters for left ventricular fibrosis in patients with dilated cardiomyopathy (DCM). 【Methods】 A total of 42 patients diagnosed with DCM complicated with left ventricular fibrosis in our hospital from January 2022 to January 2025 were prospectively enrolled as the observation group. Meanwhile, 42 healthy volunteers who underwent CMR examination during the same period were selected as the control group. Left ventricular and left atrial functional parameters were compared between the two groups, including left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), stroke volume (SV), left ventricular ejection fraction (LVEF), cardiac output (CO), cardiac index (CI), left ventricular end-diastolic myocardial mass (LVEDM), as well as left atrial strain parameters: left atrial reservoir strain (LARS), left atrial conduit strain (LACS), left atrial booster strain (LABS), late negative peak strain rate (SRa), early negative peak strain rate (SRe), and systolic peak strain rate (SRs). Receiver operating characteristic (ROC) curves were plotted to evaluate the diagnostic value of left atrial strain parameters for left ventricular fibrosis. 【Results】 The observation group had higher LVEDV, LVESV, heart rate (HR) and LVEDM, and lower SV, LVEF, CO and CI than the control group, with statistically significant differences (P<0.05). All left atrial strain parameters including LARS, LACS, LABS, SRa, SRe and SRs in the observation group were significantly lower than those in the control group (P<0.05). Multivariate Logistic regression analysis showed that LARS, LACS, LABS and SRs were independent correlated factors for the occurrence of DCM fibrosis (P<0.05). ROC curve analysis indicated that LARS yielded the highest single-test sensitivity (100.0%), while LABS presented identical and favorable specificity (92.86%). The area under the curve (AUC) and Youden index of combined detection were significantly higher than those of single parameter detection (P<0.05). 【Conclusion】 CMR-based left atrial strain parameters are closely correlated with left ventricular fibrosis in DCM patients. The combined detection achieves the optimal diagnostic efficacy, and single LARS detection presents the best sensitivity, which can serve as potential non-invasive indicators for clinical evaluation of left ventricular fibrosis in DCM patients. 2026 Vol. 43 (6): 969-972 [Abstract] ( 8 ) HTML (1 KB)  PDF (1281 KB)  ( 4 ) 973 Effects of Continuous Renal Replacement Therapy on Microinflammatory Status, Circulating Endothelial Cells, and Toll-Like Receptor 4 in Patients with Acute Renal Failure DING Huiqiang, LI Na, CHEN Shaoliang, YUN Xuejiao DOI: 10.3969/j.issn.1671-7171.2026.06.026 【Objective】 To investigate the effects of continuous renal replacement therapy (CRRT) on microinflammatory status, circulating endothelial cells (CECs), and Toll-like receptor 4 (TLR4) in patients with acute renal failure (ARF). 【Methods】 A total of 122 patients with ARF admitted to our hospital from January 2022 to January 2025 were randomly divided into an observation group and a control group, with 61 cases in each group. The observation group received CRRT, while the control group was treated with intermittent hemodialysis (HD). The microinflammatory markers [C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6)], renal function indices [blood urea nitrogen (BUN), serum creatinine (SCr)], levels of CECs and TLR4, and incidence of complications were compared between the two groups before treatment and after 2 weeks of treatment. 【Results】 After treatment, the levels of CRP, TNF-α, IL-6, BUN, SCr, CECs, and TLR4 in both groups were significantly lower than those before treatment, and the reductions were more pronounced in the observation group than in the control group (P<0.05). There was no statistically significant difference in the total incidence of complications between the two groups (P>0.05). 【Conclusion】 CRRT in patients with ARF can effectively alleviate the microinflammatory state, improve renal function, and reduce the levels of CECs and TLR4, with a favorable safety profile. 2026 Vol. 43 (6): 973-975 [Abstract] ( 8 ) HTML (1 KB)  PDF (1194 KB)  ( 4 ) 976 Anesthetic Effect of Esketamine Combined with Sevoflurane in Patients Undergoing Oral Surgery XU Depei, SUN Lisheng DOI: 10.3969/j.issn.1671-7171.2026.06.027 【Objective】 To investigate the anesthetic effect of esketamine combined with sevoflurane in patients undergoing oral surgery. 【Methods】 A total of 102 patients who underwent oral surgery from May 2021 to May 2024 were randomly divided into a control group and an observation group, with 51 cases in each group. The control group received esketamine anesthesia, while the observation group received esketamine combined with sevoflurane anesthesia. Surgical indicators, hemodynamics [heart rate (HR), mean arterial pressure (MAP)], sedation and analgesia levels [Ramsay sedation score, visual analogue scale (VAS)], and the incidence of adverse reactions were compared between the two groups. 【Results】 The onset time of anesthesia, extubation time, complete recovery time, and discharge time in the observation group were all shorter than those in the control group (P<0.05). The HR and MAP at 5 min after anesthesia induction (T1) and immediately after surgery (T2) in the observation group were lower than those in the control group (P<0.05). The Ramsay score at the time of leaving the operating room was higher in the observation group, while the VAS scores at 10 min and 30 min after recovery were lower than those in the control group (P<0.05). The total incidence of adverse reactions in the observation group was lower than that in the control group (P<0.05). 【Conclusion】 Esketamine combined with sevoflurane anesthesia in oral surgery can accelerate recovery, stabilize intraoperative hemodynamics, improve sedation, relieve postoperative pain, and reduce the incidence of adverse reactions. 2026 Vol. 43 (6): 976-978 [Abstract] ( 9 ) HTML (1 KB)  PDF (1251 KB)  ( 4 ) 979 Value of Magnetic Resonance Imaging Parameters Combined with Lumbodorsal Surface Electromyography Parameters in Evaluating Postoperative Lumbar Function in Patients with Lumbar Spinal Stenosis WANG Xiaolong, ZHANG Jianbao, ZHANG Xiyang DOI: 10.3969/j.issn.1671-7171.2026.06.028 【Objective】 To evaluate the diagnostic value of combining magnetic resonance imaging (MRI) parameters with surface electromyography (sEMG) of the lumbar paraspinal muscles in assessing postoperative lumbar function in patients with lumbar spinal stenosis (LSS). 【Methods】 A total of 63 LSS patients who underwent endoscopic decompression surgery at our hospital between February 2023 and June 2024 were enrolled. Based on their lumbar functional outcomes at 3 months postoperatively, they were divided into an improvement group and a non-improvement group. Additionally, 31 healthy individuals of similar age who underwent routine physical examinations at the same period were selected as the control group. MRI parameters and sEMG parameters of the paraspinal muscles were compared among the three groups: the improvement group, non-improvement group at 3 months post-surgery and the control group during physical examination. The diagnostic value of MRI parameters and sEMG parameters for postoperative lumbar function was assessed using receiver operating characteristic (ROC) curve analysis. 【Results】 Among the 63 LSS patients, 30.16% (19/63) showed no improvement after surgery. The spinal canal area, sagittal diameter, transverse diameter, and dural sac area in both the control group and the improvement group were significantly larger than those in the non-improvement group. Similarly, the integrated electromyography (IEMG) and mean power frequency (MPF) values were higher in the improvement and control groups compared to the non-improvement group, with all differences being statistically significant (P<0.05). ROC analysis revealed that the combination of MRI parameters and sEMG parameters yielded higher accuracy, sensitivity, and specificity in diagnosing postoperative lumbar function in LSS patients compared to either MRI or sEMG alone. 【Conclusion】 The combined use of MRI parameters and sEMG of the lumbar paraspinal muscles has high diagnostic value for assessing postoperative lumbar function in LSS patients. 2026 Vol. 43 (6): 979-982 [Abstract] ( 8 ) HTML (1 KB)  PDF (1213 KB)  ( 4 ) 983 Clinical Value of 18-Lead Electrocardiogram Combined with Echocardiography in Diagnosing Coronary Heart Disease with Myocardial Ischemia and Localizing Culprit Vessels LI Xiaomin DOI: 10.3969/j.issn.1671-7171.2026.06.029 【Objective】 To explore the clinical value of 18-lead electrocardiogram (ECG) combined with echocardiography in diagnosing coronary heart disease (CHD) complicated with myocardial ischemia and localizing culprit vessels. 【Methods】 A total of 82 patients with suspected CHD scheduled for coronary angiography admitted to our hospital from June 2023 to January 2025 were prospectively enrolled. According to coronary angiography findings, patients were divided into observation group (hemodynamically significant stenosis, n=56) and control group (no significant stenosis, n=26). The diagnostic performance of 18-lead ECG, echocardiography and their combination (defined as positive if either test showed positive result) was compared. Hierarchical Logistic regression models were established: Model 1 contained clinical baseline data; Model 2 added 12-lead ST-T changes based on Model 1; Model 3 supplemented ST-T abnormalities from additional leads of 18-lead ECG on the basis of Model 2; Model 4 incorporated echocardiographic wall motion abnormalities into Model 3. The area under the receiver operating characteristic curve (AUC) and incremental diagnostic value of each model were analyzed. 【Results】 Fifty-six patients were confirmed to have hemodynamically significant coronary stenosis. For the diagnosis of myocardial ischemia, 18-lead ECG yielded a sensitivity of 76.79%, specificity of 73.08% and AUC of 0.749; echocardiography showed a sensitivity of 73.21%, specificity of 76.92% and AUC of 0.751. Combined detection achieved a higher sensitivity of 91.07%, specificity of 69.23% and AUC of 0.802, which were all superior to single examination (P<0.05). The AUC values of Model 1 to Model 4 were 0.702, 0.752, 0.781 and 0.832 respectively. Compared with Model 4, Model 1, Model 2 and Model 3 had significantly lower AUCs with DeLong test P values of 0.004, 0.021 and 0.047 separately. The variance inflation factor (VIF) of all models was less than 5 without obvious multicollinearity, and the Hosmer-Lemeshow test showed P>0.05 for all models. 【Conclusion】 In patients admitted to chest pain center, 18-lead ECG and echocardiography have respective advantages in identifying hemodynamically significant myocardial ischemia in CHD patients. Their combination presents favorable overall diagnostic efficiency, which can be applied as a comprehensive evaluation protocol for patients with moderate-to-high risk suspected coronary heart disease. 2026 Vol. 43 (6): 983-986 [Abstract] ( 13 ) HTML (1 KB)  PDF (1277 KB)  ( 4 )

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