医学临床研究
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2026 Vol. 43, No. 3
Published: 2026-03-26

Original Articles
 
 
       Original Articles
357 Therapeutic Effect of Modified Zhenwu Decoction in Patients Undergoing Shoulder Arthroscopy During Perioperative Period
DUAN Xiaobo, ZHANG Laifu, CHANG Zhongxiao, NING Fanyou
DOI: 10.3969/j.issn.1671-7171.2026.03.002
【Objective】 To investigate the therapeutic effect of modified Zhenwu Decoction in patients undergoing shoulder arthroscopy during the perioperative period. 【Methods】 A total of 80 patients who underwent shoulder arthroscopy in our hospital from January 2023 to December 2024 were selected and divided into a control group and an observation group according to different perioperative management methods, with 40 cases in each group. The control group received routine perioperative management and standard thermal insulation, while the observation group was additionally treated with modified Zhenwu Decoction on the basis of the control group. Body temperature indicators [incidence of hypothermia, minimum core body temperature, Bedside Shivering Assessment Scale (BSAS) score], recovery indicators [awakening time, length of stay in Post-Anesthesia Care Unit (PACU)] and postoperative complications were compared between the two groups. 【Results】 The incidence of hypothermia and BSAS score in the observation group were lower than those in the control group (P<0.05), and the minimum core body temperature was higher than that in the control group (P<0.05). The postoperative awakening time and PACU stay in the observation group were shorter than those in the control group (P<0.05). There was no statistically significant difference in the total incidence of postoperative complications between the two groups (P>0.05). 【Conclusion】 The combination of modified Zhenwu Decoction and standard thermal insulation in the perioperative period of shoulder arthroscopy can reduce the risk of perioperative hypothermia, alleviate shivering, promote early recovery of patients, and shows favorable safety.
2026 Vol. 43 (3): 357-359 [Abstract] ( 23 ) HTML (1 KB)  PDF (1248 KB)  ( 6 )
360 Application of Twist-VIBE and VIBE Technique in Contrast-Enhanced Magnetic Resonance Imaging Examination of Gastric Cancer
ZHOU Yueyuan, NI Enzhen, SHAN Xiuhong
DOI: 10.3969/j.issn.1671-7171.2026.03.003
【Objective】 To explore the feasibility of time-resolved imaging with interleaved stochastic trajectories and volume interpolated breath hold examination (Twist-VIBE) technique in contrast-enhanced magnetic resonance imaging (CE-MRI) of gastric cancer. 【Methods】 A total of 55 gastric cancer patients were analyzed retrospectively, which were confirmed by gastroscopic pathological biopsy. All patients underwent Twist-VIBE and volume interpolation breath-hold examination (VIBE) T1WI scanning after injecting MRI contrast agent. Two groups of MR images were independently and subjectively scored by two radiologists based on the visualization of gastric cancer lesions, gastric wall structures, gastrointestinal peristaltic motion artifacts, respiratory motion artifacts and overall image quality. The subjective and objective evaluation results of image quality for the two imaging techniques were compared. 【Results】 There were no significant differences between Twist-VIBE and VIBE (P>0.05) regarding the visualization of gastric cancer lesions, gastric wall structure, gastrointestinal peristaltic motion artifacts, respiratory motion artifacts, and overall image quality. Furthermore, there were no statistically significant differences (P>0.05) between the two imaging techniques in terms of SNR (signal-to-noise ratio) and CNR (contrast-to-noise ratio). 【Conclusion】 There were no significant difference in image quality between Twist-VIBE and VIBE imaging techniques in CE-MRI of gastric cancer. However, with its ultra-high temporal resolution, Twist-VIBE technology can obtain multi-time arterial phase enhancement images of the gastric cancer in a single breath-hold by ensuring SNR, CNR, and spatial resolution.
2026 Vol. 43 (3): 360-363 [Abstract] ( 25 ) HTML (1 KB)  PDF (1583 KB)  ( 5 )
364 Effect of King's Interactive Goal Attainment Theory Management Program on Social Function, Daily Self-Care Ability and Self-Compassion of Patients with Schizophrenia
QIAN Danling, HU Jiaqi
DOI: 10.3969/j.issn.1671-7171.2026.03.004
【Objective】 To explore the effect of King's Interactive Goal Attainment Theory management program on social function, daily self-care ability and self-compassion of patients with schizophrenia. 【Methods】 A total of 102 patients with schizophrenia admitted to our hospital from January 2021 to January 2025 were selected and divided into an observation group and a control group according to different intervention methods, with 51 cases in each group. The control group received routine nursing intervention, while the observation group received nursing intervention based on King's Interactive Goal Attainment Theory management program. The scores of social function, daily self-care ability and self-compassion of the two groups were compared before and after intervention. 【Results】 After intervention, the scores of physical self-care, instrumental self-care and total score in both groups were higher than those before intervention, and the observation group was higher than the control group, with statistically significant differences (P<0.05). After intervention, the scores of socially useful activities, personal and social relationships, self-care, disturbance and aggressive behavior in both groups were higher than those before intervention, and the observation group was higher than the control group, with statistically significant differences (P<0.05). After intervention, the scores of self-kindness, common humanity and mindfulness in both groups were higher than those before intervention, while the scores of self-judgment, isolation and over-immersion were lower than those before intervention; in addition, the scores of self-kindness, common humanity and mindfulness in the observation group were higher than those in the control group, and the scores of self-judgment, isolation and over-immersion were lower than those in the control group, with statistically significant differences (P<0.05). 【Conclusion】 King's Interactive Goal Attainment Theory management program is helpful to improve the daily self-care ability, social function and self-compassion of patients with schizophrenia, and this program plays an important role in improving the quality of life of patients.
2026 Vol. 43 (3): 364-367 [Abstract] ( 23 ) HTML (1 KB)  PDF (1208 KB)  ( 6 )
368 Application of Combined Procalcitonin and Interleukin-6 in Predicting Sepsis among Emergency Patients with Infection
WANG Junjun, WU Chao, SUN Ming
DOI: 10.3969/j.issn.1671-7171.2026.03.005
【Objective】 To investigate the predictive value of procalcitonin (PCT) and interleukin-6 (IL-6) for the progression to sepsis in emergency patients with infection. 【Methods】 A total of 160 emergency patients with infection who progressed to sepsis in our hospital were included as the observation group. Meanwhile, 160 emergency patients with infection who did not progress to sepsis during the same period were selected as the control group. General clinical data and levels of white blood cells (WBC), PCT, and IL-6 were compared between the two groups. Univariate and multivariate logistic regression analyses were performed to identify factors influencing the progression to sepsis. Receiver operating characteristic (ROC) curves were used to evaluate the predictive performance of each indicator and their combined detection. 【Results】 The levels of WBC, PCT, and IL-6 in the observation group were significantly higher than those in the control group (P<0.05). There were no statistically significant differences between the two groups in terms of sex, age, and distribution of infection sites (P>0.05). Multivariate logistic regression analysis showed that PCT and IL-6 were independent risk factors for progression to sepsis (P<0.05). ROC curve analysis demonstrated that the area under the curve (AUC) of PCT for predicting sepsis was 0.985, with a sensitivity of 96.3% and a specificity of 97.5%; the AUC of IL-6 was 0.979, with a sensitivity of 94.4% and a specificity of 96.9%. The combined detection of both PCT and IL-6 yielded an AUC of 0.987, with a sensitivity of 96.9% and a specificity of 97.5%. 【Conclusion】 PCT and IL-6 have high early predictive value for the progression to sepsis in emergency patients with infection. PCT demonstrates superior sensitivity and specificity. Combined detection of both PCT and IL-6 can further improve predictive accuracy.
2026 Vol. 43 (3): 368-370 [Abstract] ( 18 ) HTML (1 KB)  PDF (1222 KB)  ( 4 )
371 Clinical Efficacy of Compound Intestinal Microecological Preparation Combined with Modified Low-Carbon Diet in the Treatment of Children with Simple Obesity
LU Xinjie, CAI Yingqing, ZHANG Haili, WU Huiying
DOI: 10.3969/j.issn.1671-7171.2026.03.006
【Objective】 To explore the clinical efficacy of compound intestinal microecological preparation combined with modified low-carbon diet in the treatment of children with simple obesity. 【Methods】 A total of 108 children with simple obesity admitted to our hospital from January 2022 to August 2024 were selected and divided into an observation group and a control group, with 54 cases in each group according to different treatment methods. All children in both groups received motor behavior intervention. The control group was intervened with simple energy-restricted balanced diet, while the observation group was intervened with compound intestinal microecological preparation combined with modified low-carbon diet. Both groups were treated for 6 weeks. Blood lipid indexes [total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C)], glucose metabolism indexes [fasting plasma glucose (FPG), fasting insulin (FINS), insulin resistance index (HOMA-IR)], physical and blood pressure indexes [body weight, body fat percentage, systolic blood pressure (SBP) and diastolic blood pressure (DBP)], adipocytokines [leptin, adiponectin, visfatin] and gastrointestinal adverse reactions were compared between the two groups before and after intervention. 【Results】 After intervention, the levels of TC, TG and LDL-C in both groups were lower than those before intervention, and the level of HDL-C was higher than that before intervention. Moreover, the levels of TC, TG and LDL-C in the observation group were lower than those in the control group, and the level of HDL-C was higher than that in the control group, with statistically significant differences (P<0.05). After intervention, the body weight, body fat percentage, SBP and DBP in both groups were lower than those before intervention, and those in the observation group were lower than those in the control group, with statistically significant differences (P<0.05). After intervention, the levels of FPG, FINS and HOMA-IR in both groups were lower than those before intervention, and those in the observation group were lower than those in the control group, with statistically significant differences (P<0.05). After intervention, the levels of leptin and visfatin in both groups were lower than those before intervention, and the level of adiponectin was higher than that before intervention. Furthermore, the levels of leptin and visfatin in the observation group were lower than those in the control group, and the level of adiponectin was higher than that in the control group, with statistically significant differences (P<0.05). After intervention, the incidence of constipation in the observation group was lower than that before intervention and lower than that in the control group, with a statistically significant difference (P<0.05). There were no statistically significant differences in the incidences of diarrhea and abdominal pain between the two groups (P>0.05). 【Conclusion】 Compound intestinal microecological preparation combined with modified low-carbon diet can regulate glycolipid metabolism and improve physical indexes in children with simple obesity.
2026 Vol. 43 (3): 371-374 [Abstract] ( 24 ) HTML (1 KB)  PDF (1220 KB)  ( 10 )
375 MRI Imaging Features of Congenital Tibial Pseudarthrosis in 30 Children
ZHOU Xia, LIU Raoxi, MEI Haibo, JIN Ke
DOI: 10.3969/j.issn.1671-7171.2026.03.007
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【Objective】 To explore the MRI imaging features of congenital tibial pseudarthrosis (CPT) in children with different X-ray classifications. 【Methods】 The clinical data of 30 untreated children with CPT admitted to our hospital from March 2013 to January 2024 were retrospectively analyzed. According to Crawford classification, they were divided into type Ⅰ (n=3), type Ⅱ (n=10), type Ⅲ (n=3) and type Ⅳ (n=14). Then the MRI imaging features of CPT with different classifications were analyzed. 【Results】 MRI showed that the thickening, bending, discontinuity and narrowing of the tibial shaft were basically consistent with X-ray. Regardless of the type of CPT, the periosteum was significantly thickened and showed obvious enhancement after contrast enhancement. In some children, the lesion periosteum had a wide range, which could extend to the metaphysis. The endosteum was also thickened and enhanced. The signal of the soft tissue mass in the medullary cavity and between the fracture ends was consistent with that of the lesion periosteum, showing high signal on T2 fat-suppression sequence and obvious enhancement on T1 enhancement sequence with clear boundaries. Some lesions between the fracture ends invaded the adjacent medullary cavity. 【Conclusion】 In addition to clearly showing the bone condition, MRI can also clearly show the scope of the lesion periosteum, medullary cavity and lesion tissue between the fracture ends. Therefore, MRI imaging can be used as a routine imaging examination for congenital tibial pseudarthrosis in children and can be used as a supplementary examination to X-ray.
2026 Vol. 43 (3): 375-378 [Abstract] ( 28 ) HTML (1 KB)  PDF (2847 KB)  ( 4 )
379 Clinical Effect Comparison of Implant Anchorage Combined with Different Appliances in the Treatment of Angle Class Ⅱ Malocclusion
LIANG Shuheng, FENG Hui
DOI: 10.3969/j.issn.1671-7171.2026.03.008
【Objective】 To compare the clinical effects of implant anchorage combined with different appliances in the treatment of Angle Class Ⅱ malocclusion. 【Methods】 A total of 100 patients with Angle Class Ⅱ malocclusion who visited the Department of Orthodontics in our hospital from January 2020 to January 2025 were selected and divided into four groups according to different treatment methods: group A (treated with invisible appliance + mandibular implant anchorage combined with elastic traction, n=30), group B (treated with invisible appliance + intermaxillary traction anchorage, n=30), group C (treated with fixed appliance + zygomatic alveolar crest anchorage, n=20), and group D (treated with fixed appliance + implant anchorage between the maxillary second premolar and first molar, n=20). Pain levels [visual analogue scale (VAS) score] at 1 d, 3 d and 5 d after treatment, as well as the expression rate of maxillary first and second molar displacement, distal movement distance and movement speed of molars at 6 months after treatment, temporomandibular joint parameters and periodontal indexes before and after treatment were compared among the four groups. 【Results】 At 1 d, 3 d and 5 d after treatment, the VAS score in group B was lower than those in the other three groups. At 6 months after treatment, the molar displacement expression rate and distal movement distance in group A and group C were greater than those in group B and group D, and the movement speed in group C and group D was faster than that in group A and group B (P<0.05). At 6 months after treatment, the superior joint space in group A and group B was larger than that in group C and group D, while the anterior joint space was smaller than that in group C and group D. The plaque index (PLI), probing depth (SPD), gingival index (GI) and sulcus bleeding index (SBI) in group A were lower than those in the other three groups, with statistically significant differences (P<0.05). 【Conclusion】 Both invisible appliance combined with mandibular implant anchorage and fixed appliance combined with zygomatic alveolar crest anchorage can effectively increase the distal movement distance of molars. Invisible appliance combined with intermaxillary traction can more effectively relieve postoperative pain in patients, and invisible appliances show advantages in improving periodontal health indicators.
2026 Vol. 43 (3): 379-382 [Abstract] ( 22 ) HTML (1 KB)  PDF (1272 KB)  ( 3 )
383 Clinical Effect of Bawei Tongda Decoction in Adjuvant Treatment of Patients with Variant Angina Pectoris
WANG Bin, WANG Chen, ZHANG Kangkang
DOI: 10.3969/j.issn.1671-7171.2026.03.009
【Objective】 To explore the clinical effect of Bawei Tongda Decoction in adjuvant treatment of patients with variant angina pectoris. 【Methods】 A total of 80 patients with variant angina pectoris admitted to the Wuxi Mingci Cardiovascular Hospital from December 2023 to October 2024 were selected and divided into an observation group and a control group according to different treatment methods, with 40 cases in each group. The control group was given conventional western medicine treatment, and the observation group was additionally treated with Bawei Tongda Decoction on the basis of the control group. Both groups were treated continuously for 4 weeks. The clinical efficacy, TCM syndrome scores, Seattle Angina Questionnaire scores, frequency and duration of angina pectoris attacks, as well as serum levels of malondialdehyde (MDA), nitric oxide (NO) and superoxide dismutase (SOD) were compared between the two groups. 【Results】 After treatment, the frequency and duration of angina pectoris attacks in both groups were lower than those before treatment, and the observation group was lower than the control group, with statistically significant differences (P<0.05); the scores of chest pain, chest tightness, fatigue, palpitations and shortness of breath, and dark complexion in both groups were lower than those before treatment, and the observation group was lower than the control group, with statistically significant differences (P<0.05); the serum MDA level in both groups was lower than that before treatment, and the levels of NO and SOD were higher than those before treatment; in addition, the serum MDA level in the observation group was lower than that in the control group, and the levels of NO and SOD were higher than those in the control group (P<0.05); the scores of physical activity limitation, angina stability, angina attack, treatment satisfaction and disease cognition in both groups were higher than those before treatment, and the observation group was higher than the control group (P<0.05). The total effective rate of the observation group was higher than that of the control group, with a statistically significant difference (P<0.05). 【Conclusion】 Bawei Tongda Decoction has a good clinical effect in adjuvant treatment of patients with variant angina pectoris, which can effectively relieve angina pectoris symptoms, improve vascular function and enhance the quality of life of patients.
2026 Vol. 43 (3): 383-386 [Abstract] ( 23 ) HTML (1 KB)  PDF (1220 KB)  ( 8 )
387 Application Value of Heart Rate Variability Indicators in Predicting Short-Term Prognosis of ACS Patients after PCI
XIA Yilan, YANG Weiya, SUN Ling
DOI: 10.3969/j.issn.1671-7171.2026.03.010
【Objective】 To explore the changes of heart rate variability (HRV) indicators in patients with acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI) treated with oral atorvastatin calcium tablets, and to evaluate the predictive value of HRV indicators in short-term prognosis. 【Methods】 A total of 157 ACS patients who underwent PCI in our hospital from March 2022 to May 2024 were selected. All patients took atorvastatin calcium tablets orally. According to whether major adverse cardiovascular events (MACE) occurred within 6 months after treatment, the patients were divided into a control group (no MACE occurred, n=125) and an observation group (MACE occurred, n=32). HRV indicators [standard deviation of normal-to-normal intervals (SDNN), root mean square of the differences between successive normal-to-normal intervals (rMSSD), low frequency (LF), high frequency (HF), approximate entropy (ApEn), sample entropy (SampEn), SD1, SD2] before and after treatment, 24-hour dynamic electrocardiogram indicators [turbulence slope (TS), turbulence onset (TO), 24-hour QT interval variability (24hQTV), standard deviation of the average normal R-R intervals for successive 5-minute segments (SDANN-index)], and Gensini score were compared between the two groups. Pearson correlation analysis was used to analyze the correlation between Gensini score and HRV indicators, and multivariate Logistic regression analysis was used to analyze the risk factors for MACE in ACS patients. 【Results】 The SDNN, LF, SD2 and Gensini scores in the observation group were higher than those in the control group, while rMSSD, HF and SD1 were lower than those in the control group, with statistically significant differences (P<0.05). The TS, 24hQTV and SDANN-index in the observation group were lower than those in the control group, and TO was higher than that in the control group, with statistically significant differences (P<0.05). Pearson correlation analysis showed that Gensini score was positively correlated with SDNN, LF and SD2 (r=0.266, 0.232, 0.258, all P<0.05), and negatively correlated with rMSSD, HF and SD1 (r=-0.218, -0.181, -0.242, all P<0.05). Multivariate Logistic regression analysis showed that SDNN, LF and SD2 were positively correlated with the risk of MACE in ACS patients (P<0.05), while rMSSD, HF, SD1, 24hQTV and SDANN-index were negatively correlated with the risk of MACE (P<0.05). 【Conclusion】 HRV has high value in predicting the short-term prognosis of ACS patients after PCI, and it plays an important role in evaluating the severity of patients' condition and treatment effect.
2026 Vol. 43 (3): 387-390 [Abstract] ( 19 ) HTML (1 KB)  PDF (1272 KB)  ( 3 )
391 Application Effect of Whole-Course Responsibility System Intervention Combined with Early Pulmonary Rehabilitation Training in Patients with AECOPD Complicated with Respiratory Failure
JIA Yawei, JIAO Xiaoqi, LOU Zhangju
DOI: 10.3969/j.issn.1671-7171.2026.03.011
【Objective】 To investigate the application effect of whole-course responsibility system intervention combined with early pulmonary rehabilitation training in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) complicated with respiratory failure. 【Methods】 A total of 100 patients with AECOPD complicated with respiratory failure admitted to our hospital from January 2022 to January 2025 were selected and divided into a control group and an observation group by random number table method, with 50 cases in each group. The control group received routine intervention, while the observation group received whole-course responsibility system intervention combined with early pulmonary rehabilitation training. Pulmonary function [forced expiratory volume in one second (FEV1), forced vital capacity (FVC), FEV1/FVC], respiratory rate, exercise endurance [6-minute walking distance (6MWD)], respiratory function [St. George's Respiratory Questionnaire (SGRQ)] and quality of life [Generic Quality of Life Inventory-74 (GQOLI-74) score] were compared between the two groups. 【Results】 After intervention, FEV1, FVC and FEV1/FVC in the observation group were higher than those in the control group (P<0.05), respiratory rate was lower than that in the control group, and 6MWD was longer than that in the control group (P<0.05). Scores of respiratory symptoms, physical activity limitation and impact on daily living ability in the observation group were lower than those in the control group (P<0.05). Scores of psychological function, physical function, social function and material life in the observation group were higher than those in the control group (P<0.05). 【Conclusion】 Whole-course responsibility system intervention combined with early pulmonary rehabilitation training can significantly improve pulmonary function, exercise endurance and quality of life in patients with AECOPD complicated with respiratory failure, promote the recovery of respiratory function, and has high clinical application value.
2026 Vol. 43 (3): 391-394 [Abstract] ( 18 ) HTML (1 KB)  PDF (1267 KB)  ( 4 )
395 Application Effect of Buccal Acupuncture Combined with Ultrasound-Guided Fascia Iliaca Compartment Block and General Anesthesia in Elderly Patients Undergoing Total Hip Arthroplasty
WANG Rui, LIANG Ran, LIU Ping, WANG Jing
DOI: 10.3969/j.issn.1671-7171.2026.03.012
【Objective】 To investigate the clinical effects of buccal acupuncture combined with ultrasound-guided fascia iliaca compartment block (FICB) and general anesthesia in elderly patients undergoing total hip arthroplasty (THA). 【Methods】 A total of 118 elderly patients scheduled for THA were randomly divided into an observation group and a control group, with 59 cases in each group. The control group received conventional general anesthesia, while the observation group received FICB combined with general anesthesia and buccal acupuncture therapy. Pain status [visual analogue scale (VAS) score], stress response [cortisol (Cor) and norepinephrine (NE)], serum levels [tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP), and neuron-specific enolase (NSE)], and cognitive function [Mini-Mental State Examination (MMSE) score and Montreal Cognitive Assessment (MoCA) score] were compared between the two groups. 【Results】 The VAS scores at rest and during activity of the observation group at different postoperative time points were significantly lower than those than of the control group (P<0.05). The levels of Cor and NE at 1 h and 1 d postoperatively were lower in the observation group than in the control group (P<0.05). The levels of TNF-α, IL-6, CRP, and NSE at 1 d postoperatively were lower in the observation group than in the control group (P<0.05). The MMSE and MoCA scores at 12 h, 24 h, and 48 h postoperatively were significantly higher in the observation group than in the control group (P<0.05). 【Conclusion】 Buccal acupuncture combined with FICB and general anesthesia can reduce postoperative pain, alleviate stress responses and inflammatory factor levels, and improve early postoperative cognitive function in elderly patients undergoing THA, thereby promoting postoperative recovery.
2026 Vol. 43 (3): 395-398 [Abstract] ( 19 ) HTML (1 KB)  PDF (1209 KB)  ( 5 )
399 Application of Target-Controlled Infusion of Remifentanil Combined with Propofol in Endoscopic Mucosal Resection of Colorectal Lesions
TAO Fengyu, WANG Zhichun
DOI: 10.3969/j.issn.1671-7171.2026.03.013
【Objective】 To investigate the clinical effect of target-controlled infusion (TCI) of remifentanil combined propofol in endoscopic mucosal resection (EMR) of colorectal lesions. 【Methods】 A total of 86 patients undergoing EMR were randomly divided into a control group (propofol TCI alone) and an observation group (remifentanil combined with propofol TCI). The quality of anesthesia, pain intensity [visual analogue scale (VAS)], mean arterial pressure (MAP), heart rate (HR), oxygen saturation (SpO2) before induction, at scope insertion, and 5 minutes after surgery, as well as the incidence of adverse events were compared between the two groups. 【Results】 The time to achieve adequate sedation was shorter and the maintenance rate of target sedation was higher in the observation group than in the control group (both P<0.05). The incidence of intraoperative body movement and hypoxemia was lower in the observation group compared to the control group (P<0.05). At scope insertion, MAP and HR in the observation group were lower than those in the control group, while at 5 minutes postoperatively, MAP, HR, and SpO2 in the observation group were higher than those in the control group (P<0.05). VAS scores at 2 h and 24 h postoperatively were lower than those at 5 minutes after leaving the operating room in both groups (P<0.05). However, there were no statistically significant differences in VAS scores between the two groups at 5 minutes, 2 h, or 24 h postoperatively (P>0.05). The overall incidence of adverse reactions was lower in the observation group than in the control group (P<0.05). 【Conclusion】 Compared with propofol TCI alone, remifentanil combined with propofol TCI in EMR significantly improves sedation and analgesia quality, reduces body movement and hypoxemic events, enhances perioperative physiological stability, and decreases the incidence of adverse events.
2026 Vol. 43 (3): 399-402 [Abstract] ( 21 ) HTML (1 KB)  PDF (1207 KB)  ( 6 )
403 Application Value of Continuous Theta Burst Stimulation Combined with Language Rehabilitation Training in the Rehabilitation of Patients with Language Dysfunction in Neurology Department
ZHOU Xiujuan, LIU Ru
DOI: 10.3969/j.issn.1671-7171.2026.03.014
【Objective】 To investigate the application value of continuous theta burst stimulation combined with language rehabilitation training in the rehabilitation of patients with language dysfunction in the neurology department. 【Methods】 A total of 90 patients with language dysfunction caused by cerebrovascular accidents admitted to our hospital from February 2023 to December 2024 were selected and divided into an observation group and a control group using convenience sampling method, with 45 cases in each group. The control group received language rehabilitation training alone, while the observation group received continuous theta burst stimulation combined with language rehabilitation training. Both groups were intervened for 3 months. The Boston Diagnostic Aphasia Examination (BDAE) grading, stroboscopic laryngoscopy indicators (mucosal wave, vocal cord closure, symmetry, and periodicity scores), speech disorder status [Voice Handicap Index (VHI) score], language function status [Chinese Rehabilitation Research Center Aphasia Examination (CRRCAE) score], and quality of life [World Health Organization Quality of Life Scale (WHOQOL) score] were compared between the two groups. 【Results】 The BDAE grading in the observation group was better than that in the control group (P<0.05). After intervention, the mucosal wave, vocal cord closure, symmetry, periodicity, and VHI scores in the observation group were lower than those in the control group (P< 0.05). The CRRCAE scores and WHOQOL scores in the observation group were higher than those in the control group (P< 0.05). 【Conclusion】 Continuous theta burst stimulation combined with language rehabilitation training can effectively promote the rehabilitation of patients with language dysfunction in the neurology department, improve patients' language function and speech status, and enhance patients' quality of life. It can be used as an auxiliary rehabilitation method for patients with language dysfunction.
2026 Vol. 43 (3): 403-406 [Abstract] ( 18 ) HTML (1 KB)  PDF (1266 KB)  ( 4 )
407 Clinical Study of Evolocumab Combined with Dapagliflozin in the Treatment of Patients with Atherosclerosis
ZHAO Guisheng, YANG Weiya
DOI: 10.3969/j.issn.1671-7171.2026.03.015
【Objective】 To investigate the effects of evolocumab combined with standardized conventional treatment or dapagliflozin on plaque burden and stability, lipid levels, and the incidence of major adverse cardiovascular events (MACE) in patients with atherosclerosis and concomitant diabetes. 【Methods】 A total of 124 patients with atherosclerosis complicated by diabetes, who were admitted to our hospital from January 2023 to April 2025, were selected and randomly divided into two groups, with 62 cases in each group. Patients in both groups received standardized basic treatment. Additionally, the control group was treated with dapagliflozin, while the observation group was subcutaneously injected with evolocumab. The changes in target vessel plaque volume, low-attenuation plaque volume and unstable plaque ratio were evaluated. Laboratory indicators related to blood lipids and blood glucose [low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), total cholesterol (TC), triglycerides (TG)] were detected. The occurrence of major adverse cardiovascular events (MACE) and medication-related adverse reactions were recorded. All those parameters were compared between the two groups. 【Results】 After 6 months of treatment, the total plaque volume, low-attenuation plaque volume and unstable plaque ratio in both groups were lower than those before treatment; furthermore, these values were lower in the observation group than the control group. The differences were statistically significant (P<0.05). Following treatment, levels of LDL-C, non-HDL-C, total cholesterol and triglycerides in both groups were lower than those before treatment; and these levels in the observation group were lower than in the control group (P<0.05). For HDL-C, neither inter-group nor intra-group comparisons revealed statistically significant differences (P>0.05). The incidence of MACE in the observation group was lower than that in the control group, a difference that was statistically significant (P<0.05). There was no statistically significant difference in the incidence of adverse events between the two groups (P>0.05). 【Conclusion】 On the basis of standardized treatment and dapagliflozin, the addition of evolocumab can reduce LDL-C and non-HDL-C, achieve significant regression of atherosclerotic plaques and improve plaque stability with safety, thereby reducing the risk of MACE such as ischemic cerebrovascular events.
2026 Vol. 43 (3): 407-410 [Abstract] ( 18 ) HTML (1 KB)  PDF (1210 KB)  ( 4 )
411 Correlation of HGI and cys C Levels with Diabetes Retinopathy
WANG Feiyan, HU Xumeng, LI Le
DOI: 10.3969/j.issn.1671-7171.2026.03.016
【Objective】 To explore the correlation of glycated hemoglobin variability index (HGI) and cystatin C (cys C) levels with the severity of diabetic retinopathy. 【Methods】 A total of 170 patients with diabetic retinopathy treated in our hospital from June 2023 to October 2024 were selected and divided into the non-proliferative retinopathy group (n=98) and the proliferative retinopathy group (n=72) based on the severity of diabetic retinopathy. Additionally, 83 patients with simple diabetes were selected as the control group (simple diabetes group). The correlations between HGI, cys C levels and the severity of diabetic retinopathy were analyzed. 【Results】 The proportion of high HGI and cys C levels in the proliferative retinopathy group were higher than those in the non-proliferative retinopathy group and the simple diabetes group (P<0.05). Both HGI and cys C levels were positively correlated with the severity of diabetic retinopathy (P<0.05). The duration of diabetes, fasting blood glucose (FPG), glycated hemoglobin (HbA1c), proportion of high HGI and cys C levels in the proliferative retinopathy group were higher than those in the non-proliferative retinopathy group (P<0.05). The duration of diabetes, HbA1c, high HGI and cys C were independent risk factors for proliferative diabetic retinopathy (P<0.05). The sensitivity, specificity and AUC of the combined HGI and cys C levels in predicting proliferative diabetic retinopathy were 80.56%, 97.96% and 0.893, respectively. 【Conclusion】 Both HGI and cys C levels are closely related to diabetic retinopathy. The clinical detection of HGI and cys C levels can be used as sensitive indicators for predicting proliferative diabetic retinopathy.
2026 Vol. 43 (3): 411-414 [Abstract] ( 17 ) HTML (1 KB)  PDF (1238 KB)  ( 4 )
415 Effects of Transversus Abdominis Plane Block Combined with Intravenous-Inhalation General Anesthesia on Hemodynamics in Pediatric Patients Undergoing Laparoscopic Hernia Repair
SHI Xuxu, XU Meng
DOI: 10.3969/j.issn.1671-7171.2026.03.017
【Objective】 To evaluate the impact of transversus abdominis plane (TAP) block combined with intravenous-inhalation general anesthesia on hemodynamic stability in children undergoing laparoscopic hernia repair. 【Methods】 A total of 86 children undergoing laparoscopic hernia repair were randomly divided into an observation group (TAP block combined with intravenous-inhalation general anesthesia) and a control group (intravenous-inhalation general anesthesia alone), with 43 cases in each group. Hemodynamic parameters including mean arterial pressure (MAP), heart rate (HR) and pulse oxygen saturation were recorded before anesthesia (T0), at the onset of anesthesia (T1) and at the end of surgery (T2). Postoperative agitation, pain intensity, perioperative indicators and adverse reactions were compared between the two groups. 【Results】 The observation group exhibited significantly lower MAP and HR at T1 and T2 compared with the control group (P<0.05). The Pediatric Anesthesia Emergence Delirium (PAED) scores and pain scores were significantly lower in the observation group at all measured time points (P<0.05). The observation group also presented significantly shorter anesthesia duration and extubation time (P<0.05). No significant difference was found in the total incidence of postoperative adverse reactions between the two groups (P>0.05). 【Conclusion】 TAP block combined with intravenous-inhalation general anesthesia significantly stabilizes hemodynamics, reduces postoperative pain, accelerates recovery and shows satisfactory safety in children undergoing laparoscopic hernia repair.
2026 Vol. 43 (3): 415-417 [Abstract] ( 18 ) HTML (1 KB)  PDF (1250 KB)  ( 3 )
418 Effects of Trans-Thoracic-Breast Approach Endoscopic Thyroidectomy versus Non-Inflating Trans-Axillary Approach Endoscopic Thyroidectomy on Inflammatory Factors, Endocrine Parameters, and Stress-Related Indicators in Patients with Unilateral Thyroid Cancer
LI Yayun, HUA Shenghe, WANG Xincheng, WANG Menglong
DOI: 10.3969/j.issn.1671-7171.2026.03.018
【Objective】 To compare the effects of trans-thoracic-breast approach endoscopic thyroidectomy versus non-inflating trans-axillary approach endoscopic thyroidectomy on inflammatory factors, endocrine parameters, and stress-related indicators in patients with unilateral thyroid cancer. 【Methods】 A total of 110 patients with unilateral thyroid carcinoma admitted to our hospital from January 2022 to January 2025 were selected. According to the surgical approach, they were divided into the control group (55 cases, endoscopic surgery via thoracic-breast approach) and the observation group (55 cases, non-inflating trans-axillary endoscopic surgery). The two groups were compared in terms of surgical indicators (operation time, intraoperative blood loss, number of lymph nodes dissected, postoperative drainage volume), white blood cell (WBC) count, C-reactive protein (CRP), interleukin-6 (IL-6), serum calcium, parathyroid hormone (PTH), cortisol (Cor), adrenaline (Adr), and complications (infection, subcutaneous effusion, transient hoarseness, neck discomfort). 【Results】 Intraoperative blood loss and postoperative drainage volume were lower in the observation group than in the control group (P<0.05). On postoperative day 1, levels of WBC count, CRP, and IL-6 in both groups were higher than their preoperative levels; furthermore, these levels were lower in the observation group than in the control group. The difference were statistically significant (P<0.05). Three days after surgery, there were no significant differences between the two groups in terms of serum calcium, PTH, Cor, and Adr levels (P>0.05). The complication rate in the observation group was 3.64% (2/55), which was lower than the 14.55% (8/55) in the control group (P<0.05). 【Conclusion】 Non-inflating trans-axillary endoscopic radical surgery for thyroid carcinoma is more effective in reducing intraoperative blood loss, alleviating inflammatory response and decreasing complications without increasing risks of endocrine and stress responses.
2026 Vol. 43 (3): 418-421 [Abstract] ( 21 ) HTML (1 KB)  PDF (1210 KB)  ( 4 )
422 Clinical Efficacy of Traditional Chinese Medicine Retention Enema in Patients with Recurrence after Colon Polyp Resection
SONG Pengju, WANG Shangyuan
DOI: 10.3969/j.issn.1671-7171.2026.03.019
【Objective】 To investigate the curative effect of traditional Chinese medicine retention enema in the treatment of patients with recurrence of polyps after colon polypectomy. 【Methods】 A total of 86 patients with colonic polyp recurrence who were admitted to our hospital from April 2020 to April 2025 were selected as the research objects. According to the random number table method, they were divided into the control group of 43 cases with 5-fluorouracil enema and the observation group of 43 cases with traditional Chinese medicine enema. The clinical efficacy, polyp mucosal damage score, polyp number, polyp diameter and adverse reactions were compared between the two groups. 【Results】 The total effective rate of the traditional Chinese medicine prescription group was 90.70%(39/43), which was higher than that of the control group (67.44%, 29/43). The difference was statistically significant (P<0.05). Before treatment, there were no significant differences in the score of polyp mucosal damage, the number of polyps, and the diameter of polyps between the two groups (P>0.05). After treatment, the scores for the degree of mucosal injury, the number of polyps, and the polyp diameter in both groups were lower than their respective pre-treatment levels; furthermore, the values in the observation group were lower than those in the control group, and the difference was statistically significant (P<0.05).During the treatment period, no adverse reactions such as rashes, vomiting, nausea, or impairment of liver and kidney function were observed in either group; the difference was not statistically significant (P>0.05). 【Conclusion】 Traditional Chinese medicine retention enema demonstrates favorable clinical efficacy in the treatment of patients with recurrent colon polyps after colon polypectomy. It can significantly reduce the diameter of polyps, improve mucosal damage, and reduce the recurrence rate, which is worthy of clinical promotion.
2026 Vol. 43 (3): 422-424 [Abstract] ( 20 ) HTML (1 KB)  PDF (1185 KB)  ( 4 )
425 Efficacy of Irinotecan Combined with Capecitabine and Bevacizumab in Patients with Colorectal Cancer and Liver Metastases
ZHU Jing
DOI: 10.3969/j.issn.1671-7171.2026.03.020
【Objective】 To investigate the efficacy of irinotecan combined with capecitabine and bevacizumab in patients with colorectal cancer and liver metastases. 【Methods】 A total of 100 patients with colorectal cancer and liver metastases were randomly divided into an observation group and a control group, with 50 cases in each group. The observation group received irinotecan + capecitabine + bevacizumab, while the control group received oxaliplatin + capecitabine + bevacizumab. Clinical efficacy, serum vascular endothelial growth factor (VEGF) and carbohydrate antigen 19-9 (CA19-9) levels before and after treatment, as well as the incidence of adverse reactions were compared between the two groups. 【Results】 There were no statistically significant differences between the two groups in overall response rate or disease control rate (P>0.05). After treatment, VEGF and CA19-9 levels in the observation group were lower than those in the control group (P<0.05). During an 18-month follow-up, the progression-free survival (PFS) was 9.2 months and 8.1 months, and the median overall survival (OS) was 20.5 months and 19.1 months in the observation and control groups, respectively; no statistically significant differences were found between the two groups (P>0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】 Irinotecan + capecitabine + bevacizumab shows similar efficacy and good safety compared with oxaliplatin + capecitabine + bevacizumab in patients with colorectal cancer and liver metastases; however, the observation group demonstrated greater improvements in serum VEGF and CA19-9 levels.
2026 Vol. 43 (3): 425-427 [Abstract] ( 22 ) HTML (1 KB)  PDF (1249 KB)  ( 5 )
428 Application Effect of Overlap Anastomosis in Laparoscopic Total Gastrectomy for Patients with Gastric Cancer
TANG Yanhui, JIA Qijun, SHI Yi
DOI: 10.3969/j.issn.1671-7171.2026.03.021
【Objective】 To explore the application effect of Overlap anastomosis in laparoscopic total gastrectomy for patients with gastric cancer. 【Methods】 The clinical data of 92 patients with gastric cancer admitted to our hospital from May 2019 to May 2024 were retrospectively analyzed. They were divided into an observation group and a control group according to different surgical anastomosis methods, with 46 cases in each group. The observation group was treated with Overlap anastomosis, and the control group was treated with esophagojejunal Roux-en-Y reconstruction. The perioperative indicators, postoperative recovery, pain [Visual Analogue Scale (VAS) score] and complication rate were compared between the two groups. 【Results】 There were no statistically significant differences in esophagojejunal anastomosis time, number of lymph node dissections, incision length and number of stapler cartridges between the two groups (P>0.05); the operation time and intraoperative blood loss in the observation group were lower than those in the control group, with statistically significant differences (P<0.05). The incision recovery time, ambulation time, first anal exhaust time, first feeding time and hospital stay in the observation group were all shorter than those in the control group, with statistically significant differences (P<0.05). The VAS scores of the two groups on the 3rd day after operation were significantly higher than those before operation, with statistically significant differences (P<0.05); there were no statistically significant differences in VAS scores between the two groups before operation and on the 3rd day after operation (P>0.05); the VAS score of the observation group on the 7th day after operation was lower than that on the 3rd day after operation and lower than that of the control group, with a statistically significant difference (P<0.05). The total incidence of complications in the observation group was lower than that in the control group, with a statistically significant difference (P<0.05). 【Conclusion】 Overlap anastomosis in laparoscopic total gastrectomy for gastric cancer patients results in less intraoperative blood loss, better patient recovery, and can reduce the incidence of postoperative complications, which has certain clinical value.
2026 Vol. 43 (3): 428-431 [Abstract] ( 20 ) HTML (1 KB)  PDF (1214 KB)  ( 5 )
432 Clinical Effect of Nasal Irrigation Combined with Nebulized Inhalation of Drugs in the Treatment of Pneumonia in Infants and Young Children
ZHANG Tian, DAI Fuli, ZHAO Shanshan
DOI: 10.3969/j.issn.1671-7171.2026.03.022
【Objective】 To explore the clinical effect of nasal irrigation combined with nebulized inhalation of drugs in the treatment of pneumonia in infants and young children. 【Methods】 A total of 82 children with pneumonia admitted to our hospital from July 2021 to July 2023 were selected and divided into a control group and an observation group according to different treatment methods, with 41 cases in each group. Both groups were nebulized with budesonide + terbutaline, while the observation group received nasal irrigation 30 minutes before nebulization. The symptom relief time, clinical efficacy, inflammatory factors [interleukin-6 (IL-6), C-reactive protein (CRP), white blood cell (WBC) count], and sleep quality [Pittsburgh Sleep Quality Index (PSQI) score] were compared between the two groups. 【Results】 After treatment, the time to relief of shortness of breath, wheezing, and moist rales, as well as hospital stay in the observation group were all shorter than those in the control group (P<0.05). The total effective rate of treatment in the observation group was higher than that in the control group (P<0.05). After treatment, the levels of IL-6, CRP, and WBC count in the observation group were lower than those in the control group (P<0.05), and the PSQI score in the control group was lower than that in the control group (P<0.05). 【Conclusion】 Nasal irrigation combined with nebulized inhalation of drugs in the treatment of pneumonia in infants and young children has a significant effect, can effectively improve the symptoms of children, reduce the levels of inflammatory factors, and shorten the hospital stay, which has a high clinical application value.
2026 Vol. 43 (3): 432-434 [Abstract] ( 17 ) HTML (1 KB)  PDF (1250 KB)  ( 4 )
435 Effects of Dexmedetomidine on Postoperative Stress Response and Cerebral Oxygen Metabolism in Children with Lower Limb Fractures
SHAN Chengjing, PENG Bei, WU Xiaole, YANG Chen
DOI: 10.3969/j.issn.1671-7171.2026.03.023
【Objective】 To investigate the effects of dexmedetomidine (Dex) on postoperative stress response and cerebral oxygen metabolism in children undergoing surgery for lower limb fractures. 【Methods】 A total of 86 children scheduled for lower limb fracture surgery were randomly assigned to an observation group or a control group, with 43 cases in each group. The observation group received Dex before anesthesia induction, while the control group was intravenously injected with an equal volume of normal saline. Surgical conditions, stress response indices, neurological function indices, cerebral oxygen metabolism parameters, and the incidence of adverse reactions before and after surgery were compared between the two groups. 【Results】 The times to recovery of spontaneous respiration, recovery of consciousness, and extubation were significantly shorter in the observation group than in the control group (P<0.05). At 1 h postoperatively, the visual analogue scale (VAS) score was lower and the Ramsay score was higher in the observation group than in the control group (P<0.05). Postoperatively, malondialdehyde (MDA) levels increased in both groups compared with preoperative levels (P<0.05), but the MDA level in the observation group was lower than that in the control group (P<0.05). Superoxide dismutase (SOD) and heme oxygenase-1 (HO-1) levels decreased in both groups after surgery, but they both were higher in the observation group than in the control group (P<0.05). Levels of glial fibrillary acidic protein (GFAP), neuron-specific enolase (NSE), and S100β protein were higher postoperatively in both groups (P<0.05), but they were lower in the observation group than in the control group (P<0.05). The cerebral oxygen extraction ratio (CERO2), jugular venous oxygen content (CjvO2), and arterial oxygen content (CaO2) decreased postoperatively in both groups (P<0.05). Compared with the control group, the observation group showed higher CaO2 and CjvO2 levels but a lower CERO2 level (P<0.05). There were no significant differences in the incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】 The intraoperative application of Dex in children undergoing lower limb fracture surgery provides favorable anesthetic effects, has minimal impact on postoperative stress response and neurological function, improves postoperative cerebral oxygen metabolism, and demonstrates good safety.
2026 Vol. 43 (3): 435-438 [Abstract] ( 16 ) HTML (1 KB)  PDF (1215 KB)  ( 5 )
439 Comparison of Immunity and Arthritis Antibodies in Children with Different Subtypes of Juvenile Idiopathic Arthritis
WANG Ying, QI Yaru
DOI: 10.3969/j.issn.1671-7171.2026.03.024
【Objective】 To explore the differences in immunity and arthritis antibodies in children with different subtypes of juvenile idiopathic arthritis. 【Methods】 A total of 104 children with juvenile idiopathic arthritis admitted to our clinic from October 2019 to October 2024 were selected and divided into three groups according to the type of idiopathic arthritis: systemic type group (n=38), polyarticular type group (n=24), and oligoarticular type group (n=42). Immune function indicators [lymphocyte subsets (CD3, CD4, CD8, CD4/CD8), immunoglobulin M (IgM), immunoglobulin G (IgG), immunoglobulin A (IgA), and complement C3, C4] and arthritis antibodies [anti-keratin antibody (AKA), anti-perinuclear factor (APF), anti-cyclic citrullinated peptide antibody (ACPA), rheumatoid factor (RF)-IgG] were compared among different groups. 【Results】 The levels of CD3, CD4 and the ratio of CD4/CD8 in the systemic type group were significantly higher than those in the polyarticular type group and oligoarticular type group (P<0.05), and the level of CD8 was significantly lower than that in the polyarticular type group and oligoarticular type group (P<0.05); the level of CD8 in the polyarticular type group was significantly lower than that in the oligoarticular type group (P<0.05). The levels of IgG, IgM and IgA in the systemic type group were significantly higher than those in the oligoarticular type group (P<0.05), and the levels of C3 and C4 were significantly higher than those in the polyarticular type group and oligoarticular type group (P<0.05); the levels of IgG, IgM and IgA in the polyarticular type group were significantly higher than those in the oligoarticular type group (P<0.05). The positive rates of AKA, ACPA, APF and RF-IgG in the systemic type group were lower than those in the polyarticular type group, with statistically significant differences (P<0.05); the positive rates of AKA, ACPA and APF in the polyarticular type group were higher than those in the oligoarticular type group, with statistically significant differences (P<0.05). 【Conclusion】 There are significant differences in the degree of immune dysfunction and the positive rate of arthritis antibodies in children with different subtypes of juvenile idiopathic arthritis, which may be related to their different pathogenesis.
2026 Vol. 43 (3): 439-441 [Abstract] ( 17 ) HTML (1 KB)  PDF (1256 KB)  ( 5 )
442 Efficacy of Citicoline Sodium Capsules Combined with Edaravone Dexborneol and Butylphthalide in the Treatment of Elderly Patients with Acute Progressive Cerebral Infarction
SHA Fei
DOI: 10.3969/j.issn.1671-7171.2026.03.025
【Objective】 To investigate the efficacy of citicoline sodium capsules combined with edaravone dexborneol and butylphthalide in the treatment of elderly patients with acute progressive cerebral infarction (APCI). 【Methods】 A total of 122 elderly patients with APCI were randomly divided into a control group (treated with edaravone dexborneol and butylphthalide) and an observation group (treated with citicoline sodium capsules in addition to the regimen used in the control group), with 61 cases in each group. Clinical efficacy, activities of daily living before and after treatment [Barthel Index (BI) score], neurological function [National Institutes of Health Stroke Scale (NIHSS) score], hemodynamic parameters, vascular endothelial function [vascular endothelial growth factor (VEGF) and nitric oxide (NO)], and adverse reactions were compared between the two groups. 【Results】 After treatment, the total effective rate in the observation group was higher than that in the control group (P<0.05). The BI score in the observation group was higher, while the NIHSS score was lower than those in the control group (P<0.05). The mean blood flow velocity of the middle cerebral artery and cerebral perfusion pressure in the observation group were higher than those in the control group, while the resistance index was lower (all P<0.05). The levels of VEGF and NO in the observation group were higher than those in the control group (P<0.05). There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】 Citicoline sodium capsules combined with edaravone dexborneol and butylphthalide in the treatment of elderly patients with APCI can improve clinical efficacy and activities of daily living, alleviate neurological impairment, enhance vascular endothelial function, and improve cerebral blood supply.
2026 Vol. 43 (3): 442-445 [Abstract] ( 19 ) HTML (1 KB)  PDF (1213 KB)  ( 9 )
446 Correlation between Different OCT Classifications of Retinal Vein Occlusion Macular Edema and Serum Vascular Endothelial Growth Factor Levels
HU Xumeng, WANG Feiyan
DOI: 10.3969/j.issn.1671-7171.2026.03.026
【Objective】 To investigate the correlation between different optical coherence tomography (OCT) classifications of retinal vein occlusion macular edema (RVO-ME) and serum vascular endothelial growth factor (VEGF) levels. 【Methods】 Clinical data of 138 patients (138 eyes) with RVO-ME diagnosed and treated in the ophthalmology department of our hospital from December 2022 to December 2024 were retrospectively analyzed. According to the site of retinal vein occlusion, patients were divided into central retinal vein occlusion group and branch retinal vein occlusion group. According to OCT features, RVO-ME patients were classified into diffuse retinal thickening type group (n=25), serous retinal detachment type group (n=58), and cystoid macular edema type group (n=55). Meanwhile, 50 patients (50 eyes) undergoing cataract surgery who were diagnosed and treated in our ophthalmology department and excluded from fundus diseases were selected as the control group. Serum VEGF levels were measured and compared among all groups. 【Results】 Serum VEGF levels in both central retinal vein occlusion group and branch retinal vein occlusion group were significantly higher than those in the control group (P<0.05). There were statistically significant differences in the distribution of central retinal vein occlusion and branch retinal vein occlusion among diffuse retinal thickening type, serous retinal detachment type and cystoid macular edema type RVO-ME patients (P<0.05). Statistically significant differences were found in serum VEGF levels among RVO-ME patients with different OCT classifications (P<0.05). 【Conclusion】 Serum VEGF levels differ in RVO-ME patients with different OCT classifications, and are closely related to the site of retinal vein occlusion and the type of macular edema, suggesting that VEGF may play an important role in the pathogenesis and progression of RVO-ME.
2026 Vol. 43 (3): 446-448 [Abstract] ( 16 ) HTML (1 KB)  PDF (1254 KB)  ( 4 )
449 Influencing Factors of Bone Flap Replantation Decision in Decompressive Craniectomy for Patients with Severe Spontaneous Intracerebral Hemorrhage
ZHANG Cheng, LI Jinhui
DOI: 10.3969/j.issn.1671-7171.2026.03.027
【Objective】 To explore the clinical factors influencing the decision of bone flap replantation during decompressive craniectomy in patients with severe spontaneous intracerebral hemorrhage. 【Methods】 The clinical data of 64 patients with severe spontaneous intracerebral hemorrhage admitted to our hospital from February 2022 to February 2025 were retrospectively analyzed. According to whether the bone flap was replanted during the operation, the patients were divided into the replantation group (n=30) and the non-replantation group (n=34). The baseline data and clinical characteristics of the two groups were compared. Univariate and multivariate Logistic regression were used to screen the clinical factors related to the bone flap replantation decision, and the short-term good prognosis rate of the two groups was compared. According to the Glasgow Outcome Scale (GOS) score 3 months after operation, the patients in the replantation group were further divided into the good prognosis group (n=18) and the poor prognosis group (n=12), and the related factors affecting the prognosis of the patients with bone flap replantation were analyzed. 【Results】 The age of patients in the replantation group and the incidence of acute intraoperative cerebral herniation, hematoma rupture into the ventricle and midline shift were lower than those in the non-replantation group, with statistically significant differences (P<0.05). Multivariate Logistic regression analysis showed that age, hematoma rupture into the ventricle, acute intraoperative cerebral herniation and midline shift were the influencing factors for bone flap replantation in patients with severe spontaneous intracerebral hemorrhage (all P<0.05). After 3 months of follow-up, 18 patients (60.00%) in the replantation group had a good prognosis, and 12 patients (35.29%) in the non-replantation group had a good prognosis. The good prognosis rate of the replantation group was higher than that of the non-replantation group (χ2=3.906, P=0.048). Among the patients with bone flap replantation, the age, incidence of midline shift, postoperative hydrocephalus and severe cerebral edema 2 weeks after operation in the poor prognosis group were higher than those in the good prognosis group, and the GCS score 1 week after operation was lower than that in the poor prognosis group, with statistically significant differences (P<0.05). 【Conclusion】 Age, hematoma rupture into the ventricle, acute intraoperative cerebral herniation and midline shift are the key clinical factors affecting the decision of bone flap replantation during decompressive craniectomy in patients with severe spontaneous intracerebral hemorrhage. For patients with replantation conditions, those who receive primary replantation have a significantly higher short-term good prognosis rate. However, among patients with bone flap replantation, advanced age, preoperative midline shift, postoperative hydrocephalus, severe cerebral edema and poor early neurological status are still important indicators of poor short-term prognosis.
2026 Vol. 43 (3): 449-452 [Abstract] ( 20 ) HTML (1 KB)  PDF (1216 KB)  ( 4 )
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