|
|
|
| Application of Combined Procalcitonin and Interleukin-6 in Predicting Sepsis among Emergency Patients with Infection |
| WANG Junjun, WU Chao, SUN Ming |
| Department of Emergency Medicine, Suqian Hospital Affiliated to Nanjing Drum Tower Hospital Group,Suqian Jiangsu 223800 |
|
|
|
|
Abstract 【Objective】 To investigate the predictive value of procalcitonin (PCT) and interleukin-6 (IL-6) for the progression to sepsis in emergency patients with infection. 【Methods】 A total of 160 emergency patients with infection who progressed to sepsis in our hospital were included as the observation group. Meanwhile, 160 emergency patients with infection who did not progress to sepsis during the same period were selected as the control group. General clinical data and levels of white blood cells (WBC), PCT, and IL-6 were compared between the two groups. Univariate and multivariate logistic regression analyses were performed to identify factors influencing the progression to sepsis. Receiver operating characteristic (ROC) curves were used to evaluate the predictive performance of each indicator and their combined detection. 【Results】 The levels of WBC, PCT, and IL-6 in the observation group were significantly higher than those in the control group (P<0.05). There were no statistically significant differences between the two groups in terms of sex, age, and distribution of infection sites (P>0.05). Multivariate logistic regression analysis showed that PCT and IL-6 were independent risk factors for progression to sepsis (P<0.05). ROC curve analysis demonstrated that the area under the curve (AUC) of PCT for predicting sepsis was 0.985, with a sensitivity of 96.3% and a specificity of 97.5%; the AUC of IL-6 was 0.979, with a sensitivity of 94.4% and a specificity of 96.9%. The combined detection of both PCT and IL-6 yielded an AUC of 0.987, with a sensitivity of 96.9% and a specificity of 97.5%. 【Conclusion】 PCT and IL-6 have high early predictive value for the progression to sepsis in emergency patients with infection. PCT demonstrates superior sensitivity and specificity. Combined detection of both PCT and IL-6 can further improve predictive accuracy.
|
|
Received: 04 November 2025
|
|
|
|
|
|
[1] 史健,雷静,刘泽世,等.数字PCR和二代测序技术在脓毒血症患者病原学诊断中的应用价值[J].中华微生物学和免疫学杂志,2025,45(3):256-263.
[2] SAWICKI J G, GRAHAM J, LARSEN G, et al. Harbingers of sepsis misdiagnosis among pediatric emergency department patients[J].Diagnosis,2025, 12(2): 241-249.
[3] 谭晓梅,谭茂华,谭雪梅,等. 耐药肺炎克雷伯菌感染脓毒症患者血清NLRP3、PCT、CCL25水平及与预后的关系[J].检验医学与临床,2025,22(15):2026-2032.
[4] 段盈霜,黄超,谷柳莹,等. LYM、IL-6及DD对脓毒症患者28天预后的预测价值[J].医学研究杂志,2024,53(9):108-112.
[5] SINGER M, DEUTSCHMAN C S, SEYMOUR C W, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3)[J].JAMA,2016, 315(8): 801-810.
[6] WENG L, XU Y, YIN P, et al. National incidence and mortality of hospitalized sepsis in China[J].Crit Care,2023, 27(1): 84.
[7] 赵云,张磊,马晓晨,等. C反应蛋白与前白蛋白比值在脓毒症诊断和预后评估中的应用价值[J].中国医师进修杂志,2024,47(2):123-128.
[8] 赵刚,单思阳,何月月,等. 血清HNL、PCT、sCD163及IL-6联合检测在老年患者脓毒症诊断中的应用价值[J].四川医学,2024,45(6):582-586.
[9] 赵媛,刘晶,宁欣. 动态监测老年重症肺炎患者IL-6、HBP、CRP水平对并发脓毒症的预测价值[J].河北医药,2023,45(11):1628-1631.
[10] 赵静媛,张玉红,董龙,等. PCT、D-D联合CRP水平动态检测在脓毒症分级及转归评估中的意义[J].分子诊断与治疗杂志,2024,16(5):894-898.
[11] 张伟,邢娟,谢辉. 革兰菌感染脓毒症患者炎症因子含量与其病情和预后关系[J].热带医学杂志,2023,23(5):678-682.
[12] 李攀,段红茹,陈芳,等. G-菌血流感染患者循环sCD14-ST、G6PD、乳酸与PCT、CRP、内毒素的相关性及对脓毒症的预测价值[J].检验医学与临床,2025,22(10):1410-1415.
[13] 梁德林,方丽,肖孟,等. 早期IL-6、D-二聚体联合APACHEⅡ评分对腹腔脓毒症患者院内死亡风险评估的价值[J].现代医学,2025,53(7):1096-1102.
[14] 李晓飞,王静. 中性粒细胞CD64与白细胞介素-6和降钙素原对ICU脓毒症患者的诊断及预后评估[J].中华危重病急救医学,2023,35(5):463-468. |
|
|
|
2026, Vol. 43 
