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Quick Search     Adv Search 2021 Vol. 38, No. 8 Published: 2021-08-26   1124 Application of Fast Track Surgery in Patients with Peripheral Lung Cancer Undergoing Single Port Thoracoscopic Lobectomy DU Li-hong, GU Xue-yan DOI: 10.3969/j.issn.1671-7171.2021.08.002 【Objective】To explore the application value of fast track surgery (FTS) in patients with peripheral lung cancer undergoing single port thoracoscopic lobectomy. 【Methods】A total of 180 patients with peripheral lung cancer in our hospital from January 2018 to December 2019 were randomly divided into the FTS group and the conventional rehabilitation group, with 90 cases in each group. All patients underwent single port thoracoscopic lobectomy. The conventional rehabilitation group received routine rehabilitation intervention during perioperative period, while the FTS group received perioperative intervention based on FTS concept, the intervention lasted until 1 day before discharge. The operation situation, postoperative recovery, complications, rehabilitation satisfaction, VAS and SaO2 were compared between the two groups. 【Results】The operation time of FTS group was significantly shorter than that of conventional rehabilitation group (P<0.05). The time of getting out of bed, postoperative extubation and hospital stay in FTS group were significantly lower than those in conventional rehabilitation group (P<0.05). The incidence of postoperative complications in FTS group was 5.56%, which was lower than 15.56% in conventional rehabilitation group (P<0.05). The postoperative rehabilitation satisfaction of FTS group was 96.67%, which was higher than 78.89% of conventional rehabilitation group (P<0.05). The VAS scores of FTS group at 4 h, 24 h and 48 h after operation were all lower than those of conventional rehabilitation group (P<0.05). The resting SaO2 of FTS group was higher than that of conventional rehabilitation group at 2 days after operation, and the difference was statistically significant (P<0.05). 【Conclusion】The perioperative intervention based on FTS concept can shorten the operation time of single port thoracoscopic lobectomy for peripheral lung cancer, promote postoperative recovery, improve patients' rehabilitation satisfaction and reduce postoperative pain. 2021 Vol. 38 (8): 1124-1127 [Abstract] ( 43 ) HTML (1 KB)  PDF (1186 KB)  ( 49 ) 1128 Relationship between the Expression of Vascular Endothelial Growth Factor Receptor and Therapeutic Effect in Patients with Advanced PHC after TACE WANG Hui, TANG Min, SHEN Ying, et al DOI: 10.3969/j.issn.1671-7171.2021.08.003 【Objective】To investigate the relationship between the expression of vascular endothelial growth factor receptor (VEGFR) and the efficacy of patients with advanced primary liver cancer (PHC) after transcatheter arterial chemoembolization (TACE). 【Methods】A total of 83 PHC patients were selected as the research subjects. All patients were treated with TACE. The patients were divided into the clinically controlled and clinically uncontrolled patients according to the recent clinical efficacy. The serum VEGFR-2 and VEGFR-3 levels of clinically controlled and clinically uncontrollable patients at 1 d before operation and 5 d after operation were compared, and the relationship of the short-term curative effect with serum VEGFR-2 and VEGFR-3 levels in PHC patients were analyzed. The clinicopathological characteristics were evaluated among cases with VEGFR-2/VEGFR-3 reduction and without reduction. Patients were followed up for 1 year. Kaplan-Meier method was used to draw the survival curve and the log-rank test was used to analyze the relationship of △VEGFR-2 and △VEGFR-3 with overall survival (OS).ROC was used to analyze the value of △VEGFR-2 and △VEGFR-3 in predicting the death of PHC patients. 【Results】The levels of serum VEGFR-2 and VEGFR-3 in all patients after TACE were lower than those on the first day before surgery (P<0.05). The reduction rates of △VEGFR-2 and △VEGFR-3 in clinically controlled patients were both higher than those under clinically uncontrolled (P<0.05).Patients without VEGFR-2 and △VEGFR-3 reduction showed higher proportion of Child-Pugh grade B, serum AFP level, VEGF level, the proportion of combined liver cirrhosis, and the tumor size than those with △VEGFR-2 and △VEGFR-3 reduction (P<0.05).After 1-year follow-up, the overall survival rate (OS) of patients with reduced △VEGFR-2 was higher than that of VEGF2 unreduced cases (Log Rankχ2 =10.428, P=0.001). △VEGFR-3 reduced patients had a higher OS than unreduced ones (Log Rank χ2=4.696, P=0.030).ROC curve results showed that the area under the curve (AUC) of △VEGFR-2, △VEGFR-3, △VEGFR-2 combined with △VEGFR-3 to predict death of PHC patients were 0.777, 0.756, 0.915, respectively (P<0.05). 【Conclusion】The levels of serum VEGFR-2 and VEGFR-3 in patients with advanced PHC at 1 day before TACE and 5 days after operation are closely related to the efficacy. And △VEGFR-2 and △VEGFR-3 can be used to predict the survival of patients with advanced PHC. 2021 Vol. 38 (8): 1128-1131 [Abstract] ( 44 ) HTML (1 KB)  PDF (1353 KB)  ( 23 ) 1132 Effect of Laparoscopic Hysterectomy on Pelvic Floor Function and Immune Function in Patients with Uterine Diseases SHI Yu, REN Li, GUO Yun-hong DOI: 10.3969/j.issn.1671-7171.2021.08.004 【Objective】To investigate the effect of laparoscopic hysterectomy on pelvic floor function and immune function in patients with uterine diseases. 【Methods】A total of 80 patients who underwent hysterectomy in Zhongxin Central Hospital from June 2016 to October 2018 were selected and divided into the observation group and the control group (with 40 cases in each group) according to the treatment method. The observation group was treated with laparoscopic hysterectomy, while the control group was treated with open hysterectomy. The changes of PFIQ-7, PFDI-20, T lymphocyte subsets, immunoglobulin and complement levels were compared between the two groups before and after operation. 【Results】The scores of PFDI-20 and PFIQ-7 at 6 and 12 months after operation in the two groups were higher than those before operation and (P<0.05), while the scores of PFDI-20 and PFIQ-7 at 12 months after operation were higher than those at 6 months after operation (P<0.05). PFDI-20 and PFIQ-7 scores of the observation group were lower than those of the control group (P<0.05). The IgG level in the two groups decreased, while the level of IgG in the observation group were significantly higher than that in the control group (P<0.05). The levels of C4 and C3 in the observation group were higher than those in the control group (P<0.05). Level of CD4+, CD3+, CD8+ and CD4+/CD8+ in the control group were significantly lower than those in the observation group; The differences were statistically significant (P<0.05). 【Conclusion】Laparoscopic hysterectomy can improve the immune function of patients, and has little effect on the pelvic floor function. 2021 Vol. 38 (8): 1132-1135 [Abstract] ( 41 ) HTML (1 KB)  PDF (1188 KB)  ( 98 ) 1136 Lymph Node Metastasis and Influencing Factors in Mixed Early Gastric Cancer ZHANG Xue-yan, GUO Chun-fang, WU Jiang DOI: 10.3969/j.issn.1671-7171.2021.08.005 【Objective】To explore the lymph node metastasis status and its influencing factors in mixed early gastric cancer . 【Methods】A total of 94 patients with mixed early gastric cancer admitted to the First Affiliated Hospital of the Fourth Military Medical University from January 2018 to January 2020 were selected to sort the basic data of patients (gender, age, TNM grade, underlying disease , tumor location, tumor size, tumor number, tumor differentiation, combined ulcers, depth of invasion, etc.). Based on imaging data in combination with pathological results, the patients were evaluated for lymph node metastasis. Thus patients were divided into the metastatic group and non-metastatic group according to whether there was lymph node metastasis. Logistic regression analysis was used to explore the related factors affecting lymph node metastasis in mixed early gastric cancer.【Results】Among the 94 patients with mixed early gastric cancer in this study, 22 patients had lymph node metastasis (the metastasis group), accounting for 23.40%. While 72 patients did not have lymph node metastasis (the non-metastasis group), accounting for 76.60%. The proportion of patients with tumor size≥2 cm, poorly differentiated tumors, combined ulcers and depth of invasion to the submucosa in the metastasis group was higher than that in the non-metastasis group; and the difference was statistically significant (P<0.05). The results of multivariate analysis showed that the tumor size ≥2 cm, poorly differentiated tumor, combined ulcer and depth of invasion to the submucosa in the metastasis group were risk factors for lymph node metastasis in patients with mixed early gastric cancer (P<0.05).【Conclusion】In the metastasis group, patients with mixed early gastric cancer with tumor size ≥ 2 cm, poorly differentiated tumors, combined with ulcers and deep infiltration to the submucosa have a higher risk of lymph node metastasis. 2021 Vol. 38 (8): 1136-1138 [Abstract] ( 49 ) HTML (1 KB)  PDF (1164 KB)  ( 55 ) 1139 Analysis of Sexual Dysfunction and Risk Factors in Female Patients with Condyloma Acuminatum after Treatment CHEN Bao-shan, GUO Rui-hua DOI: 10.3969/j.issn.1671-7171.2021.08.006 【Objective】To investigate the sexual dysfunction and risk factors of female patients with condyloma acuminatum after treatment. 【Objective】 The clinical data of 96 female patients with condyloma acuminatum treated in Shaanxi rehabilitation hospital from January 2018 to January 2020 were analyzed retrospectively. The incidence of sexual dysfunction after treatment was analyzed, and the general data such as age, education and bad living habits were counted. The influencing factors of sexual dysfunction after treatment were analyzed by univariate and multivariate logistic regression. 【Results】 A total of 96 patients completed the treatment successfully, and 33 patients had sexual dysfunction after treatment, accounting for 34.38%; 63 cases had no sexual dysfunction after treatment, accounting for 65.62%, which were included in the asexual dysfunction group. Univariate analysis showed that the sexual dysfunction of female patients with condyloma acuminatum after treatment was correlated with education, combined diseases, human papillomavirus 16 (HPV16), drinking, staying up late and the location of skin lesions (P<0.05). Multivariate logistic regression analysis showed that education level (OR=1.147, 95%CI=1.021~1.289), HPV16 (OR=2.517, 95%CI=1.185~5.346), drinking (OR=4.156, 95%CI=1.325~13.036), staying up late (OR=4.153, 95%CI=1.354~12.738), skin lesion site (OR=5.913, 95%CI=2.385~14.660) was an independent risk factor for sexual dysfunction in female patients with condyloma acuminatum after treatment (P<0.05). 【Conclusion】 The disorder of sexual function in female patients with condyloma acuminatum after treatment is closely related to their education, HPV16, drinking, staying up late and the location of skin lesions. 2021 Vol. 38 (8): 1139-1142 [Abstract] ( 49 ) HTML (1 KB)  PDF (1186 KB)  ( 66 ) 1143 Comparison of Incidence of Perioperative Complications between Parkinson's Disease Orthopedic Surgery and Non-orthopedic Surgery Patients:A retrospective analysis YANG Man, ZOU Xiao-hua, LI Hui, et al DOI: 10.3969/j.issn.1671-7171.2021.08.007 【Objective】We retrospectively analyzed the incidence of perioperative complications between Parkinson's disease orthopedic surgery and non-orthopedic surgery patients to provide the basis of the perioperative management of Parkinson's patients (PD). 【Methods】Parkinson's disease patients who accept surgical treatment in our hospital during January 2014 to December 2019 were selected. All patients were divided into the orthopedic group and non-orthopedic group. The basic information, the use rate of postoperative analgesia pump and the incidence of perioperative complications were compared. 【Results】Among 84 Parkinson's disease patients with surgery, there were 25 cases in the orthopedics group and 59 cases in the the non-orthopedic group. The basic information showed no significance in statistics between two groups(P>0.05). The use rate of postoperative analgesia pump in the orthopedics group was higher than that in the non-orthopedic group (P<0.05).The incidence of postoperative pain in the orthopedics group was higher than that in the non-orthopedic group (P<0.05).The vasoactive agent usage, postoperative pulmonary infection, urinary tract infection, wound infection, gastrointestinal reactions, postoperative delirium, arrhythmia, cardiac insufficiency and respiratory insufficiency did not show statistical significance between two groups (P>0.05). 【Conclusion】The incidence of postoperative pain in Parkinson's disease patients with orthopedic surgery is higher than Parkinson's disease with non-orthopedic surgery. 2021 Vol. 38 (8): 1143-1145 [Abstract] ( 41 ) HTML (1 KB)  PDF (1166 KB)  ( 55 ) 1146 Application of Laparoscopic High Ligation of Hernia Sac Combined with Median Umbilical Fold in Treatment of Unilateral Inguinal Hernia in Children SHENG Jian-yun, HE Pei-na, WANG Jie-shi DOI: 10.3969/j.issn.1671-7171.2021.08.008 【Objective】To investigate the application of laparoscopic high ligation of hernia sac and median umbilical fold in treatment of unilateral inguinal hernia in children. 【Methods】The clinical data of 241 children with unilateral inguinal hernia treated in our hospital from July 2015 to March 2018 were collected. According to different treatment methods, all of the children were divided into the control group (n=96) and the observation group (n=145). Laparoscopic high ligation of hernia sac and laparoscopic high ligation of hernia sac combined with median umbilical fold were performed respectively. The perioperative period, postoperative complications and recurrence after 1 years of the two groups were compared. 【Results】The operative time, hospitalization time and pain score at 24 h of the two groups had no significant difference (P>0.05). There was no significant difference between the two groups in incision infection, hydrocele and groin pain (P>0.05). One year follow up after operation showed that there was no recurrence in the observation group, however, there were 3 cases (3.13%) in the control group. The difference between the two groups was statistically significant (P<0.05). 【Conclusion】Laparoscopic high ligation of hernia sac combined with median umbilical fold in treatment of unilateral inguinal hernia is effective. It can significantly reduce postoperative recurrence rate. 2021 Vol. 38 (8): 1146-1148 [Abstract] ( 46 ) HTML (1 KB)  PDF (1166 KB)  ( 122 ) 1149 Predicting Value of Combined Detection of Multiple Tumor Markers in the Early Diagnosis of Postoperative Recurrence of Ovarian Cancer CHEN Yan, GUO Yu-ge DOI: 10.3969/j.issn.1671-7171.2021.08.009 【Objective】To explore the value of combined detection of multiple tumor markers in the early diagnosis of postoperative recurrence of ovarian cancer. 【Methods】A total of 104 patients with ovarian cancer suspected of recurrence in the pelvic and abdominal cavity who were admitted to our hospital from January 2016 to February 2019 were selected as the research subject. Serum carcinoembryonic antigen (CEA) was determined by electrochemiluminescence immunoassay. Levels of carbohydrate antigen 125 (CA125), carbohydrate antigen 199 (CA199) and serum human epididymal protein 4 (HE4) were determined by enzyme-linked immunosorbent assay. The ROC curve was used to calculate the area under the curve (AUC) and to analyze the diagnostic value of the independent and combined detection of serum CEA, HE4, CA125, and CA199 for the recurrence of ovarian cancer. 【Results】Of 104 patients with suspected pelvic and abdominal cavity recurrence, a total of 80 patients were confirmed pathologically with pelvic and abdominal cavity recurrence, and 24 patients did not relapse. CEA, CA125, and CA199 levels of patients with pelvic and abdominal cavity recurrence were higher than those of non-recurring patients (P<0.05). The AUC of the combined detection of recurrence and metastasis of ovarian cancer was 0.950, the sensitivity was 95.71%, the specificity was 80.00%, and the positive likelihood ratio was 4.79, which was significantly higher than the single detection of each index (P<0.05). 【Conclusion】The combined detection of serum CEA, HE4, CA125, and CA199 can effectively improve the diagnosis rate and has very important diagnostic significance for early recurrence of ovarian cancer. 2021 Vol. 38 (8): 1149-1151 [Abstract] ( 47 ) HTML (1 KB)  PDF (1264 KB)  ( 175 ) 1152 Effect of Intra-articular Injection of Sodium Hyaluronate on Serum TNF- α ,COX-2 expression and VAS scorein Patients with Scapulohumeral Periarthritis LIN Guang-sheng, YANG Wang-li DOI: 10.3969/j.issn.1671-7171.2021.08.010 【Objective】To investigate the effect of intra-articular injection of sodium hyaluronate on serum tumor necrosis factor in patients with scapulohumeral periarthritis- α(TNF-α),Cyclooxygenase-2 (COX-2) expression and pain visual analogue scale (VAS). 【Methods】A total of 160 patients with Scapulohumeral Periarthritis treated in the pain department of our hospital from March 2017 to March 2020 was randomly divided into control group (n=80) and observation group (n=80). The control group was treated with routine treatment, and the observation group was treated with intra-articular sodium hyaluronate injection on the basis of the control group. After one month of treatment, the clinical efficacy (effective rate) and TNF -α, COX-2, VAS score and active range of motion (AROM) of shoulder jointbefore and after treatment were compared between the two groups.【Results】The clinical effective rate of the observation group was better than that of the control group (85.00% vs 62.50%), χ2=10.460, P<0.05), the scores of COX-2 and VAS in the observation group were significantly improved compared with those in the control group [(12.47±2.33) pg/mL vs (16.67±3.43)pg/mL, (1.42±1.10)score vs (2.34±1.31)score, P<0.05]; The AROM of shoulder flexion, extension and abduction in the observation group was significantly improved compared with that in the control group [(161.14±18.33)° vs (145.67±14.45)°, (50.25±6.57)° vs (38.64±7.40)°, (133.20±14.37)° vs (124.36±14.07)°, P<0.05]. There was no significant difference TNF-αof two groups [(29.32±10.10)pg/mL vs (31.64±9.31)pg/mL,P>0.05]. 【Conclusion】Intra-articular sodium hyaluronate injection can effectively inhibit the inflammatory response, improve the pain symptoms and joint activity dysfunction in patients with scapulohumeral periarthritis. 2021 Vol. 38 (8): 1152-1155 [Abstract] ( 33 ) HTML (1 KB)  PDF (1186 KB)  ( 62 ) 1156 Opportunistic Screening of 381 Patients with Colorectal Cancer MA Chun-tao, XU Chun-fang, SHEN Fang, et al DOI: 10.3969/j.issn.1671-7171.2021.08.011 【Objective】To analyze the clinical data of 381 patients with colorectal cancer in our hospital, so as to explore the opportunistic screening strategy of colorectal cancer. 【Methods】 The clinical data of 381 patients with colorectal cancer in our hospital from January 2014 to December 2019 were analyzed retrospectively. The demographic characteristics, biochemical data and histological types of patients were analyzed. The age distribution, location and histological types of colorectal cancer patients of different genders were compared, and the high-risk factors of colorectal cancer patients were analyzed.【Results】The ratio of male to female in 381 patients was 1.23∶1. The proportion of 61~70 years old was the highest (30.4%), followed by 71~80 years old (21.8%) and 51 ~ 60 years old (21.3%). There was no significant difference in the age distribution of colorectal cancer patients between different genders(χ2=1.166,P=0.979>0.05). There was no significant difference in the age of colorectal cancer between different genders (P>0.05). The most common location was rectosigmoid colon (272 cases, 71.4%), and the most common histological type was adenocarcinoma (288 cases, 75.6%). There was no significant difference in the location and histological type of colorectal cancer between different genders (P>0.05). There was no significant difference in the location and histological type of colorectal cancer at different ages (P>0.05). The investigation data of 114 patients with high-risk factors were complete, with a total of 191 high-risk factors, among which FOBT positive and abnormal defecation were the most common. Among 114 patients, 110 (96.5%) had high-risk factors, and more than two high-risk factors accounted for 74.5%. 【Conclusion】 The proportion of colorectal cancer under 50 years old is high, and there is little difference in the age, location and type of colorectal cancer between different genders. Age and gender restrictions should not be made for opportunistic screening. The opportunistic screening of colorectal cancer should pay attention to the population with positive FOBT test, abnormal defecation and more than two high-risk factors. 2021 Vol. 38 (8): 1156-1158 [Abstract] ( 41 ) HTML (1 KB)  PDF (1165 KB)  ( 36 ) 1159 Relationship of Urinary Phthalate Metabolites with Premature Ovarian Failure and Reproductive Hormones in Women TIAN Yu-quan, ZHANG Yan-fang, ZHANG Min DOI: 10.3969/j.issn.1671-7171.2021.08.012 【Objective】To investigate the correlation of urinary phthalate metabolites (PM) with premature ovarian failure (POF) and reproductive hormones in women. 【Methods】A total of 81 patients with POF in our hospital from January 2019 to December 2020 were selected as the study group, according to the ratio of 1:2 principle, 162 healthy women in our hospital during the same period were selected as the control group. The levels of estrogen (E2) and follicle stimulating hormone (FSH) were detected. The levels of MiBP (mono-iso-butyl phthalate), MnBP (mono-n-butyl phthalate), MBzP (mono-benzyl phthalate), MEHP (mono(2-ethylhexyl) phthalate), MEHHP (mono(2-ethyl-5-hydroyhexyl) phthalate) and MEOHP (mono(2-ethyl-5-oxohexyl) phthalate) were measured as well. The relationship of PM with POF, E2 and FSH was analyzed. 【Results】The level of E2 in the study group was lower than that in the control group and its FSH level was higher than that in the control group. The difference between the two groups was statistically significant (P<0.05). MiBP level of the study group was higher than that of the control group and the MEHP level was lower than that of control group. The differences were statistically significant (P<0.05). There were no significant differences in the levels of MnBP, MBzP, MEOHP, and MEHHP between the two groups (P>0.05). MiBP was positively correlated with POF (P<0.05). MiBP, MnBP were negatively correlated with E2 (P<0.05), and FSH was positively correlated with MiBP, MnBP, MEOHP, and MEHHP (P<0.05). 【Conclusion】The concentration of MiBP in urine is correlated with the occurrence of POF, and a number of PM are correlated with female hormone levels. PM-related chemicals have a risk on female reproductive health. 2021 Vol. 38 (8): 1159-1162 [Abstract] ( 58 ) HTML (1 KB)  PDF (1194 KB)  ( 61 ) 1163 Effect of Mindful Behavior Training Combined with Empathy Nursing on Coping Style and Quality of Life of Lung Cancer Patients Undergoing Chemotherapy ZHANG Meng, NIU Ai-hua, SUN Yan-hong DOI: 10.3969/j.issn.1671-7171.2021.08.013 【Objective】To explore the effect of mindful behavior training combined with empathy nursing on the coping style and quality of life of patients with lung cancer chemotherapy. 【Methods】A total of 128 lung cancer chemotherapy patients admitted to the Provincial Hospital of Shandong First Medical University from January 2017 to December 2019 were selected and divided into the observation group and the control group with 64 cases each by random table method. The control group was given routine nursing intervention, and the observation group was combined with mindful behavior training and empathy nursing. The psychological stress, coping style and quality of life of the two groups were compared. 【Results】Before the intervention, there was no significant difference in the scores of the Self-Rating Anxiety Scale (SAS) and the Self-Rating Depression Scale (SDS) between the two groups before the intervention (P>0.05); after the intervention, the SAS and SDS scores of the two groups were significantly lower than those before the intervention (P<0.01), and the SAS and SDS scores of the observation group were significantly lower than those of the control group (P<0.05). There was no significant difference in the scores of the two groups of coping styles before the intervention (P>0.05); after the intervention, the scores of the coping styles of the two groups were significantly better than those before the intervention (P<0.05), and the scores of the observation group were excellent In the control group (P<0.05). There was no significant difference in the quality of life scores between the two groups before the intervention (P>0.05); after the intervention, the quality of life scores of the two groups were improved compared with that before the intervention (P<0.05), and the scores of all dimensions of the quality of life of the observation group were compared with those of the control The group improved significantly (P<0.05).【Conclusion】Mindful behavior training combined with empathy nursing can help relieve anxiety and depression in patients with lung cancer chemotherapy, avoid negative coping behaviors, actively face chemotherapy treatment, and improve the quality of life. 2021 Vol. 38 (8): 1163-1165 [Abstract] ( 43 ) HTML (1 KB)  PDF (1162 KB)  ( 49 ) 1166 Positive Rate of HTLV Ⅰ/Ⅱ Antibody in Unpaid Blood Donors in Jinan and the Influencing Factors of HTLV Ⅰ/Ⅱ Awareness Among Local Residents SHANG Jie, MA Hong-xia, WANG Fu-juan DOI: 10.3969/j.issn.1671-7171.2021.08.014 【Objective】To explore the positive rate of human T-cell virus (HTLV) Ⅰ/Ⅱ antibody in unpaid blood donors in Jinan and the influencing factors of HTLV Ⅰ/Ⅱ awareness among residents in Jinan. 【Methods 】ELISA was used to detect the positive rate of HTLV Ⅰ/Ⅱ in 326,408 blood donation samples from January to December 2020 in Jinan. The resident population (including temporary and permanent residents) in Jinan were investigated by questionnaire, telephone and Internet, and the awareness rate and influencing factors of HTLV Ⅰ/Ⅱ in Jinan were analyzed. 【Results 】A total of 91 anti HTLV Ⅰ/Ⅱ antibody positive specimens were screened from 326408 blood donors, and the positive rate was 0.0279% (91/326,408). There was no significant difference in the incidence of HTLV Ⅰ/Ⅱ between patients of different gender and age (P>0.05). 91 patients with HTLV Ⅰ/Ⅱ positive took blood samples again 3 ~ 6 months (median time 4.5 months), and 8 patients were diagnosed as positive samples. 4812 valid questionnaires were collected. The awareness rate of HTLV was 35.08% (1608/4812), and the good awareness rate was 2.49% (120/4812). HTLV awareness rate of people aged 30~49, junior college or above, mental work and blood donation history was significantly higher (P<0.05), but there was no significant difference in HTLV awareness among different gender, nationality, marital status and registered residence (P>0.05). The rate of HTLV awareness was significantly higher in the group with blood donation history (P<0.05), and there was no significant difference in the HTLV awareness rate among the different gender, age, nationality, education level, occupation and registered residence (P>0.05). 【Conclusion】The positive rate of HTLV Ⅰ/Ⅱ in Jinan population is relatively low, and the residents are lack of HTLV Ⅰ/Ⅱ knowledge. It is necessary to attract the attention of relevant departments and carry out HTLV knowledge publicity and education through multiple channels to reduce the transmission of HTLV Ⅰ/Ⅱ. 2021 Vol. 38 (8): 1166-1169 [Abstract] ( 41 ) HTML (1 KB)  PDF (1191 KB)  ( 24 ) 1170 Changes of Intestinal Microecology and Immune Function in Children before and after Helicobacter Pylori Eradication Treatment LYU Rong-fen, HU Jun-wei DOI: 10.3969/j.issn.1671-7171.2021.08.015 【Objective】To explore the changes of intestinal microecology and immune function in children before and after Helicobacter pylori (Hp) eradication treatment. 【Methods】The clinical data of 91 children with HP infection admitted to the hospital from September 2017 to March 2020 were retrospectively analyzed. All children were treated with a quadruple standardized radical cure for HP infection. The changes of intestinal microecology and immune function in children before and after eradication treatment were compared. Drug safety was evaluated. 【Results】After treatment, the proportion of Escherichia coli, Enterococcus, Clostridium, and Parabacteroides was higher than before treatment (P<0.05), The proportion of Pretotella, Bifidobacterium, Lactobacillus, Koala, Bacteroides was lower than before treatment (P<0.05). CD3+, CD4+ and CD4+/CD8+ levels after treatment were higher than those before treatment (P<0.05), while CD8+ level after treatment was lower than before treatment (P<0.05). The levels of IgA, IgM and IgG after treatment in children were higher than before treatment (P<0.05). The children had no obvious adverse reactions, and the safety was good during the treatment. 【Conclusion】The structure of the intestinal flora changes in children with Hp infection after eradication treatment, which can effectively improve their immune function. 2021 Vol. 38 (8): 1170-1172 [Abstract] ( 42 ) HTML (1 KB)  PDF (1162 KB)  ( 38 ) 1173 Correlation Between IMR and Left Ventricular Remodeling in Patients with NSTEMI MENG Juan, GENG Jue, LIU Zhen-guo DOI: 10.3969/j.issn.1671-7171.2021.08.016 【Objective】To investigate the correlation between coronary microcirculation resistance index (IMR) and left ventricular remodeling in patients with non ST segment elevation myocardial infarction (NSTEMI). 【Methods】A total of 112 patients with NSTEMI treated in the Department of Cardiology of our hospital from January 2018 to January 2019 were selected. According to whether there was left ventricular remodeling after PCI, they were divided into remodeling group (n=23) and non remodeling group (n=89). 12 months after interventional surgery and discharge, the left ventricular ejection fraction (LVEF), left ventricular end diastolic volume (LVEDV) and left ventricular end systolic volume (LVESV) of the two groups were recorded. The cardiac function of the two groups was compared, the correlation between IMR and cardiac function was analyzed, and the clinical value of IMR in identifying left ventricular remodeling was analyzed by receiver operating characteristic (ROC) curve. 【Results】 Before discharge, there was no significant difference in LVEF, LVEDV and LVESV between the two groups (P>0.05). 12 months after operation, LVEF in the remodeling group was lower than that before discharge, and LVEDV and LVESV were significantly higher than that before discharge; LVEF in the remodeling group was significantly lower than that in the non remodeling group, and LVEDV was significantly higher than that in the non remodeling group (all P<0.05). The IMR of patients in remodeling group was (38.75 ± 6.31) u, which was significantly higher than that in non remodeling group (23.47 ± 4.96) U (P<0.05). Pearson correlation analysis showed that IMR was significantly negatively correlated with LVEF (r=-0.296, P=0.038), and positively correlated with LVEDV and LVESV (r=0.492 and 0.371, P=0.018 and 0.047, respectively). ROC curve analysis showed that the value of IMR in predicting left ventricular remodeling 12 months after PCI in NSTEMI patients was (AUC) (95%CI) 0.86 (0.79~0.95). 【Conclusion】IMR is a potential index to predict the prognosis of NSTEMI patients. Clinicians can give effective treatment measures in time according to IMR, which is of great clinical significance to improve the prognosis of patients. 2021 Vol. 38 (8): 1173-1175 [Abstract] ( 51 ) HTML (1 KB)  PDF (1263 KB)  ( 25 ) 1176 Diagnostic Value of Modified Roll Test in Benign Paroxysmal Positional Vertigo of Horizontal Semicircular Canal XIAO Ben-jie, BI Yong, ZHENG Tian-heng, et al DOI: 10.3969/j.issn.1671-7171.2021.08.017 【Objective】By improving the classical roll test, to explore its diagnostic value in benign paroxysmal positional vertigo of horizontal semicircular canal. 【Methods】 The clinical data of 57 patients with horizontal canal benign paroxysmal positional vertigo (HC-BPPV) were collected from October 1, 2017 to December 31, 2019, At the same time, the classic roll test and the improved roll test (head roll improved from 90°to 180°) were given to compare their effects on the duration of nystagmus and the diagnosis of the affected side of HC-BPPV. Finally, the success of manual reduction was used as the final diagnostic verification and correction, and all diagnostic processes were observed and completed under the naked eye.【Results】Comparing the duration and duration difference of nystagmus between the affected side and the healthy side, there was significant difference between the modified roll test and the classical roll test, whether it was free otolith or adhesive otolith (P<0.05); There was no significant difference between the modified roll test and the classical roll test in the diagnosis rate of the affected side of free otolith (P=0.242 > 0.05), but there was significant difference in the diagnosis rate of adhesive otolith (P<0.05). 【Conclusion】 Compared with the classical roll test, the improved roll test makes the difference of nystagmus on both sides more obvious, helps to better judge the affected side of HC-BPPV, and effectively improves the diagnostic rate of HC-BPPV with adhesive otolith, but has little effect on the diagnostic rate of HC-BPPV with free otolith. 2021 Vol. 38 (8): 1176-1178 [Abstract] ( 39 ) HTML (1 KB)  PDF (1168 KB)  ( 67 ) 1179 Clinical Value of Colposcopy Negative Quadrant Biopsy, ECC and TCT Combined Detection in the Diagnosis of High-grade Cervical Lesions PAN Lin, SUN Li, SONG Wen-rong DOI: 10.3969/j.issn.1671-7171.2021.08.018 【Objective】To investigate the diagnostic value of colposcopy negative quadrant biopsy, cervical curettage (ECC) and liquid based thin layer cell assay (TCT) in high-grade cervical lesions (HSIL+). 【Methods】A total of 185 patients with abnormal pedestrian papillomavirus (HPV) screening in our hospital from March 2020 to March 2021 were selected as the research objects. They need to further undergo colposcopy negative quadrant biopsy, ECC and TCT. All patients underwent cervical conization for histopathological examination. Taking the histopathological examination results after cervical conization as the gold standard, the consistency between colposcopy negative quadrant biopsy, ECC, TCT alone and combined diagnosis of HSIL+ and pathological diagnosis was analyzed. 【Results】 Among 185 patients, 33 cases of LSIL (CINI) and 152 cases of HSIL+ were detected by histopathological diagnosis after cervical conization. The positive rate of HSIL+ was 82.16% (152/185); The coincidence rate between the results of colposcopy negative quadrant biopsy and histopathological diagnosis after cervical conization was 72.43%, with moderate consistency (Kappa value was 0.607); The coincidence rate between ECC and histopathological diagnosis after cervical conization was 85.95% (Kappa value 0.799); The coincidence rate between TCT and histopathological diagnosis after cervical conization was 80.00%, which was highly consistent (Kappa value was 0.715); The coincidence rate between the results of colposcopy negative quadrant biopsy, ECC and TCT and the histopathological diagnosis after cervical conization was 94.59%, which was highly consistent (Kappa value was 0.922). 【Conclusion】 Colposcopy negative quadrant biopsy, ECC and TCT are reliable methods for the diagnosis of HSIL+, and the combined examination of the three methods is helpful to improve the detection rate and diagnostic accuracy of HSIL+. 2021 Vol. 38 (8): 1179-1182 [Abstract] ( 44 ) HTML (1 KB)  PDF (1594 KB)  ( 88 ) 1183 Correlation Between Preoperative Blood Platelet-to-Lymphocyte Ratio and Prognosis of Thyroid Cancer REN Bo-bo, MIN Qi DOI: 10.3969/j.issn.1671-7171.2021.08.019 【Objective】To explore the correlation between preoperative blood platelet-to-lymphocyte ratio (PLR) and clinical prognosis of thyroid cancer. 【Methods】A total of 258 cases of thyroid cancer treated in our hospital from January 2018 to January 2021 were enrolled in the study. According to value of PLR, they were divided into group A (PLR ≤ 150, 168 cases) and group B (PLR > 150, 90 cases). The data of preoperative Triiodothyronine (T3),serum total thyroxine (T4) levels, preoperative anti-thyroglobulin antibody (Tg-Ab), anti-thyroid peroxidase antibody (TPO-Ab), Hashimoto's thyroiditis, TNM staging, tumor size, pathological type and lymph node metastasis were collected. All patients were required to have a follow-up visit every 3 months after surgery, for 4 times in total. Ultrasonography was performed for every review, and fine-needle aspiration biopsy pathological examination would be performed, if necessary, to determine the tumor recurrence. Statistical analysis was performed on the obtained data. 【Results】There were no significant differences in Tg-Ab, TPO-Ab, Hashimoto's thyroiditis, TNM staging, and lymph node metastasis between two groups (P>0.05). There were significant differences in serum T3 and T4 levels, tumor size, and pathological types between two groups before surgery (P<0.05). Tumor size, pathological type, and preoperative serum T3 and T4 levels were independent influencing factors of preoperative PLR (P<0.05). There was no significant difference in the tumor recurrence rates between two groups at 6th, 9th and 12th months after surgery (P>0.05). 【Conclusion】Tumor size, pathological type, and preoperative serum T3 and T4 levels are influencing factors of preoperative PLR, but the predictive effect of preoperative PLR on the prognosis of thyroid cancer needs further study. 2021 Vol. 38 (8): 1183-1186 [Abstract] ( 42 ) HTML (1 KB)  PDF (1184 KB)  ( 42 ) 1187 Analysis of Related Factors of Postoperative Pain in Patients Undergoing Primary Total Hip Arthroplasty YE Li-li, JIANG Xiao-xiao DOI: 10.3969/j.issn.1671-7171.2021.08.020 【Objective】To explore the related factors affecting postoperative pain in patients undergoing primary total hip arthroplasty. 【Methods】The clinical data of 114 patients who underwent total hip arthroplasty from March 2016 to April 2019 were analyzed retrospectively. The patients were followed up for 2 weeks. According to the postoperative pain visual analog score (VAS), the patients were divided into moderate and severe pain group (VAS ≥ 4, observation group) and mild pain group (VAS ≤ 3, control group). The related factors that may affect postoperative pain were observed, and univariate analysis and binary logistic regression analysis were carried out. 【Results】 The postoperative follow-up showed that 23 of 114 patients had hip pain within 2 weeks after operation, and the incidence was 20.18%; The age, postoperative leukocyte (WBC), C-reactive protein (CRP) and VAS scores of the observation group were higher than those of the control group; The postoperative functional exercise time was shorter than that in the control group (P<0.05); The incidence of pain increased with the increase of anxiety (P<0.05); Multivariate logistic regression analysis showed that short postoperative functional exercise time, large length difference of both lower limbs, and increase of WBC and CRP were independent risk factors for pain after hip arthroplasty (OR=3.08, 3.52, 3.90, 3.89;P<0.05). 【Conclusion】The postoperative pain of patients undergoing total hip arthroplasty is affected by many factors. Short postoperative exercise time, large difference in the length of both lower limbs, and elevated levels of WBC and CRP were independent risk factors for pain after hip arthroplasty. Clinically, we should formulate reasonable operation methods according to the differences of patients, and avoid the occurrence of risk factors as far as possible. 2021 Vol. 38 (8): 1187-1190 [Abstract] ( 48 ) HTML (1 KB)  PDF (1181 KB)  ( 44 ) 1191 Correlation between IL-6 Level and Neoadjuvant Chemotherapy in Triple-negative Breast Cancer YU Jin-yu, LIU Da-lin, WANG Qi-peng, et al DOI: 10.3969/j.issn.1671-7171.2021.08.021 【Objective】To investigate the correlation between IL-6 levels and neoadjuvant chemotherapy for triple-negative breast cancer. 【Methods】A total of 120 patients with locally advanced breast invasive ductal carcinoma who underwent preoperative neoadjuvant chemotherapy in our hospital. The immunohistochemical results were all triple negative breast cancer. The level of IL-6 in peripheral blood before neoadjuvant chemotherapy was measured, and the correlation between IL-6 level and clinicopathological factors was analyzed. The correlation between chemotherapy and pathological complete remission (pCR) was analyzed. 【Results】The IL-6 level was (119.8±20.8) pg/mL. According to the median IL-6 level (118 pg/ml), the patients were divided into IL-6 low level group (60 cases) and IL-6 high level group (60 cases). There was no correlation of IL-6 level with age, menopausal status, tumor size and clinical stage in triple-negative breast cancer patients (P>0.05). IL-6 level was correlation with clinical stage and lymph node status of triple-negative breast cancer, the difference was statistically significant(P<0.05). The CR rate in the IL-6 high-level group was lower than that in the IL-6 low-level group, and the effective rate was lower than the IL-6 low-level group , the difference was statistically significant (P<0.05). A total of 25 patients had pCR after operation, and pCR was associated with clinical stage, IL-6 level, and tumor longest interval (P<0.05). Multivariate regression analysis showed clinical stage, IL-6 levels were independent factors affecting pCR. 【Conclusion】The level of IL-6 is associated with the efficacy of neoadjuvant chemotherapy for triple-negative breast cancer. The high-level IL-6 level of triple-negative breast cancer patients has a lower pCR rate. 2021 Vol. 38 (8): 1191-1193 [Abstract] ( 37 ) HTML (1 KB)  PDF (1168 KB)  ( 28 ) 1194 Bacterial Distribution and Drug Sensitivity Analysis of Nasal Secretions in Children with Chronic Rhinosinusitis XU Xue-feng, LIU Hui, YAO Lei DOI: 10.3969/j.issn.1671-7171.2021.08.022 【Objective】To explore the bacterial distribution and drug sensitivity analysis of nasal secretions in children with chronic rhinosinusitis (CRS). 【Methods】A total of children with CRS and healthy children in the same period were selected. Nasal secretions were collected from two groups to detect the distribution of bacteria, fasting peripheral blood was collected to detect the level of serum IgE, and the drug sensitivity of bacteria isolated from children was analyzed by K-B disk agar diffusion method.【Results】The positive rate of bacterial culture in the observation group was 70.49% (43/61), and the positive rate of serum IgE was 75.41% (46/61), which was significantly higher than 3.28% (2/61) and 1.64% (1/61) in the control group (P<0.05); Spearman correlation analysis showed that the positive rate of serum IgE was positively correlated with the positive rate of bacteria in nasal secretions (r=0.549, P<0.05). A total of 53 strains of bacteria were cultured from nasal secretions of children, of which 15 children (24.59%, 15/61) were infected with more than two kinds of bacteria, 16 strains of bacteria producing β- Lactamase (β- LPB) (30.19%, 16/53); There were 29 strains of Gram-positive bacteria, accounting for 54.72% (29/53), and 24 strains of Gram-negative bacteria, accounting for 45.28% (24/53). Among them, Haemophilus influenzae, Streptococcus pyogenes and Streptococcus pneumoniae accounted for a high proportion. The antibiotics with high sensitivity of 29 Gram-positive bacteria were linezolid, archamycin, vancomycin, rifampicin and cefuroxime, and the antibiotics with high sensitivity of 24 Gram-negative bacteria were amikacin, cefoperazone, sulbactam, imipenem, aztreonam and ceftazidime. 【Conclusion】 There is a positive correlation between bacterial positive nasal secretion and serum IgE positive in children with CRS, which may participate in the occurrence and development of CRS. Gram positive bacteria and gram negative bacteria in nasal secretions of children with CRS are highly sensitive to most antibiotics. The drug sensitivity results have important reference value for antibiotic treatment of CRS. 2021 Vol. 38 (8): 1194-1197 [Abstract] ( 48 ) HTML (1 KB)  PDF (1178 KB)  ( 50 ) 1198 Correlation between NLR and Condition and Short-term Prognosis in Patients with ACS HE Yao-li, DU Jiang-xin, XIE Bing-qing DOI: 10.3969/j.issn.1671-7171.2021.08.023 【Objective】To investigate the correlation between neutrophil lymphocyte ratio (NLR) and the condition and short-term prognosis of patients with acute coronary syndrome (ACS). 【Methods】 A total of 136 patients with ACS treated in the Department of Cardiology of our hospital from November 2016 to September 2019 was selected. The patients were divided into high NLR group (NLR 3.51, n=68) and low NLR group (NLR < 3.51, n=68) according to the NLR value. The subjects were followed up for 30 days after discharge. The end point of follow-up was the occurrence of major adverse cardiovascular events and the follow-up time was recorded. The basic clinical data, severity and number of vascular lesions were compared between the two groups. 【Results】The left ventricular ejection fraction (LVEF) in low NLR group was higher than that in the high NLR group, the levels of serum troponin I (cTnI), creatine kinase isoenzyme (CK-MB), the proportion of multi vessel lesions and MACE in the low NLR group were higher than those in the high NLR group (P<0.05). Pearson correlation analysis showed that NLR had a positive correlation with cTnI (r=0.761, P<0.05), no significant correlation with CK-MB (r=0.518, P=0.071>0.05), and a negative correlation with LVEF (r=-0.692, P<0.01). Multiple logistic regression analysis showed that cTnI and NLR were closely related to mace in patients with ACS, and their odds ratios (OR) (95%CI) were 1.58 (1.07~3.14) and 1.26 (0.81~2.75) respectively (P<0.05). Kaplan Meier survival curve showed that the survival rate without MACE event in the low NLR group was significantly higher than that in the high NLR group (P<0.05). 【Conclusion】 NLR is a potential index to evaluate the condition, the number of diseased vessels and the short-term prognosis of ACS. 2021 Vol. 38 (8): 1198-1200 [Abstract] ( 57 ) HTML (1 KB)  PDF (1277 KB)  ( 23 ) 1201 Effects of Sini Powder Combined with Fluoxetine on Memory Function and Levels of Serum IL-10 and IL-1β in Female Patients with Anxiety Disorder ZHOU Lei, YAN Fang-fang, WU Hai-hong DOI: 10.3969/j.issn.1671-7171.2021.08.024 【Objective】To investigate the effect of Sini Powder combined with fluoxetine on memory function in female patients with anxiety disorders. 【Methods】From February 2018 to April 2020, 106 female anxiety patients in our hospital were selected and divided into the observation group (n=53) and the control group (n=53) according to the random number table. The control group was given fluoxetine, and the observation group was given Sini powder combined with fluoxetine, both were treated for 2 months. The efficacy, the scores of Hamilton Anxiety Scale (HAMA), Pittsburgh Sleep Quality Index (PSQI) and Wechsler Memory Scale (WMS-RC), event-related potential P300 (amplitude and latency of N2 and P3), serum neurotransmitter indexes [dopamine (DA), norepinephrine (NE), serotonin (5-HT)], IL -10, and IL-1β level before treatment, 1 month and 2 months after treatment of the two groups were compared. 【Results】The total effective rate of the observation group (92.45%, 49/53) was higher than that of the control group (75.47%, 40/53) after 2 months of treatment; and there was biostatistics significance (P<0.05). The HAMA and PSQI scores of the observation group were lower than those of the control group after 1 month and 2 months of treatment (P<0.05).The instantaneous memory, short-term memory, long-term memory, and memory quotient scores of the observation group were higher than those of the control group after 1 month and 2 months of treatment (P<0.05). The serum IL-10 and IL-1β levels in the observation group were lower than those in the control group after 1 month and 2 months of treatment (P<0.05). 【Conclusion】Sini powder combined with fluoxetine has a significant effect on the treatment of female anxiety. It is helpful to correct central neurotransmitter disorders, relieve anxiety, improve memory function, and improve sleep quality. 2021 Vol. 38 (8): 1201-1203 [Abstract] ( 38 ) HTML (1 KB)  PDF (1163 KB)  ( 34 ) 1204 Correlation Analysis of Sex Hormone Levels and T-lymphocyte in Patients with Autoimmune Ovarian Failure LI Li-li, MA Jin DOI: 10.3969/j.issn.1671-7171.2021.08.025 【Objective】To investigate the correlation between sex hormone levels and T lymphocytes in patients with autoimmune premature ovarian failure (POF). 【Methods】A total of 80 patients with autoimmune POF in our hospital from January 2017 to January 2020 were selected as the observation group, and 80 healthy women were selected as the control group. Levels of estradiol (E2), luteinizing hormone (LH), follicle stimulating hormone (FSH), T lymphocytes [Cluster of differentiation 3 positive (CD3+), Cluster of differentiation 4 positive (CD4+), Cluster of differentiation 8 positive ( CD8+)], and CD4+/CD8+ was were measured and calculated. The correlation between the levels of sex hormones and T-lymphocytes in patients with autoimmune POF was analyzed by Spearman coefficient. 【Results】Compared to the control group, the observation group had lower E2 level, higher LH and FSH levels; and the difference was statistically significant (P<0.05). Compared to the control group, the observation group showed lower percentage of CD4+T cells and CD4+/CD8+ ratio, while the level of CD8+ T cells was higher. The differences were statistically significant (P<0.05).There was no significant difference in the levels of CD3+ T cells between the two groups(P>0.05). According to correlation analysis, E2 level in patients with autoimmune POF was positively correlated with CD4+ T cells percentage and CD4+/CD8+ ratio, while negatively correlated with CD8+ T cell percentage. The differences were statistically significant (P<0.05).LH and FSH levels were negatively correlated with CD4+ T cells, CD4+/CD8+ ratio, and positively correlated with CD8+ T cells levels. The differences were statistically significant (P<0.05). There were no obvious correlation between CD3+ T cell percentage and levels of E2, LH and FSH(P>0.05). 【Conclusion】Compared with normal women, patients with autoimmune premature ovarian failure have obvious disorder of sex hormone levels and immune function. E2 level is positively correlated with CD4+ T cells and CD4+/CD8+ ratio, and negatively correlated with CD8+ T cells. LH and FSH levels are negatively correlated with CD4+ T cells and CD4+/CD8+ ratio, and positively correlated with CD8+ T cells. 2021 Vol. 38 (8): 1204-1207 [Abstract] ( 42 ) HTML (1 KB)  PDF (1189 KB)  ( 91 ) 1208 Application Value of CLND in Patients with cN0 DTC and Analysis of Related Factors of Central Lymph Node Metastasis WANG Xiao-fang, LIU Qiao-yan, YAO Jia DOI: 10.3969/j.issn.1671-7171.2021.08.026 【Objective】To investigate the value of central lymph node dissection (CLND) in the operation of cN0 (cervical lymph node negative) differentiated thyroid cancer (DTC) and the related factors of central lymph node metastasis. 【Methods】A total of 140 patients with cN0 DTC who underwent surgery in our hospital from April 2016 to April 2019 were retrospectively analyzed. According to whether CLND was performed during the operation, they were divided into observation group (n=80, CLND was performed during the operation) and control group (n=60, CLND was not performed during the operation). The occurrence of hoarseness, hypocalcemia, local recurrence and reoperation were compared between the two groups. The central lymph nodes obtained from 80 patients undergoing CLND were examined pathologically, and the related factors of central lymph node metastasis in patients with cN0 DTC were analyzed. 【Results】 There was no significant difference in the incidence of hoarseness and hypocalcemia between the observation group and the control group (P>0.05); After 36 months of follow-up, the local recurrence rate and reoperation rate in the control group were higher than those in the observation group (P<0.05). 80 patients in the observation group underwent central lymph node dissection. Postoperative pathological examination found that 23 patients had positive central lymph node metastasis (positive group) and 57 patients had negative central lymph nodes (negative group). Univariate analysis showed that cN0 DTC lesions > 1.0 cm and capsule invasion were related to central lymph node metastasis (P<0.05). 【Conclusion】The focus > 1.0 cm and capsule invasion in patients with cN0 DTC are related to central lymph node metastasis. CLND operation plays a positive role in reducing postoperative local recurrence in patients with cN0 DTC. 2021 Vol. 38 (8): 1208-1210 [Abstract] ( 36 ) HTML (1 KB)  PDF (1164 KB)  ( 32 ) 1211 Effect of Immediate Load and Tilted Implant in the Restoration of Tooth Loss LIU Xiao-bin, DUAN Zhi-bin DOI: 10.3969/j.issn.1671-7171.2021.08.027 【Objective】To investigate the effect of immediate load and tilted implant in the restoration of tooth loss. 【Methods】From January 2015 to January 2017, 18 patients were prospectively selected. All patients were followed up for 3 years, staring from 6 months after surgery. Various indexes were recorded immediately after load (T0), 6-month (T1), 1-year (T2) and 3-year (T3) after treatment. There included marginal bone levels (MBLs), mid-buccal mucosal levels (MBMLs), implant success rate, implant stability quotient (ISQ), prosthodontic maintenance, prosthodontic complications, pink esthetic score (PES), and white esthetic score (WES). Then the aesthetic effect was discussed. 【Results】Of the 18 patients, 4 cases did not have complete follow-up records (1 implant failed before restoration, 1 case had bilateral first molars missing, and 2 cases were lost to follow-up). The remaining 14 cases with a total of 15 single implant crowns finished 4 years follow-up. The success rate of implant was 93.33% during the 3-year follow-up period (14/15). Compared to the data at T0, the value of MBLS and MBMLs increased at T1, T2 and T3 (P<0.05); and MBMLs value increased at T2 and T3 compared to T1 (P<0.05), however, the value of MBLS and MBMLs at T2 showed no significant difference compare to T3 (P>0.05). ISQ values of mesial and distal papilla at T1, T2 and T3 were lower than those at T0 (P<0.05),while the values at T2 and T3 had no obvious changes, which showed no significant different from those at T1 (P>0.05). Compared to T0, the RES and WES scores at T1, T2, and T3 were significantly higher, and the difference was statistically significant (P<0.05). After that, the RES and WES scores at T2 and T3 changed slightly, and there were no statistical differences compared to T1 (P>0.05).At T1, there were some prosthodontic maintenance issues involving the definitive implant crowns which included fracture of veneering ceramic and zirconia abutment as well as aesthetic concerns. At T2 and T3, there were no further prosthodontic maintenance issues reported and no screw loosening was evident. During the 3-year follow-up period, RES and WES had no significant changes. There were 1 case of implant loosening, 1 case of abutment pain and 1 case of gingivitis, all of which were significantly improved by active treatment. 【Conclusion】Application of immediate load and tilted implant in single-tooth implant restoration has high success rate and aesthetic effect. 2021 Vol. 38 (8): 1211-1213 [Abstract] ( 36 ) HTML (1 KB)  PDF (1164 KB)  ( 44 ) 1214 Application of Safflower Huayu Soup Fumigation and Washing in Rehabilitation after Knee Arthroscopy XIN Yu-xi DOI: 10.3969/j.issn.1671-7171.2021.08.028 【Objective】To explore the curative effect of Safflower Huayu Decoction on knee joint swelling, pain and other complications after arthroscopic surgery. 【Methods】 A total of 96 cases of the arthroscopic surgery patients from November 2016 ~ November 2019were randomly divided into the control group and the treatment group, with 48 cases in each group. Patients in the control group received routine rehabilitation treatment after arthroscopic surgery , while patients in the treatment group received traditional Chinese medicine Safflower Huayu (local fumigation and washing around knee) in addition to routine rehabilitation therapy. The course was 8 weeks in both groups. The swelling degree of knee joint, visual analogue scale (VAS) score and knee joint function score (HSS) were observed before rehabilitation, 4 weeks and 8 weeks after treatment. 【Results】After 4 and 8 weeks of treatment, the knee joint swelling value and VAS score of the treatment in the two groups of patients were significantly lower than before treatment (P<0.05); and those indicators in the treatment group were lower than those in the control group (P<0.05). Afterwards there was no significant difference in the swelling value of the treated knee joint between the two groups (P>0.05), while the difference in VAS scores was still statistically significant (P<0.05). After 4 and 8 weeks of treatment, the HSS scores of the two groups were higher than before treatment (P<0.05), while the treatment group was higher than the control group (P<0.05). There was a statistically significant difference in HSS scores between the two groups at the end of the 4th week and the 8th week (P<0.05). 【Conclusion】The Safflower Huayu Decoction has a significant effect on the rehabilitation of patients after knee arthroscopy. It can relieve the swelling of the joints, improve the pain of the patients, improve the function of the knee joints, and is safe and free of adverse reactions. It is worthy of clinical application. 2021 Vol. 38 (8): 1214-1217 [Abstract] ( 38 ) HTML (1 KB)  PDF (1188 KB)  ( 45 ) 1218 Lymphocyte and Immune Factor Levels in Patients with Lupus Nephritis and Relationship with Disease Progression KANG Yun-hui, ZHANG Xing DOI: 10.3969/j.issn.1671-7171.2021.08.029 【Objective】To investigate the relationship of innate lymphocyte (ILC) and immune factor levels in peripheral blood of patients with activity of lupus nephritis. 【Methods】A total of 94 patients with lupus nephritis admitted to our hospital were divided into the active group (SLEDAI ≥ 10 points, 54 cases) and the stable group (SLEDAI <10 points, 40 cases) according to the systemic lupus erythematosus disease activity index (SLEDAI) score. The healthy subjects in the same period were selected as the control group (40 cases). Flow cytometry was used to detect the percentage of ILC1, ILC2, ILC3 in peripheral blood, and to detect interleukin-33 (IL-33), IL-4, interferon-γ (IFN-γ), IgG, C3 and C4. The correlation among ILC, immune factors (IL-33, IL-4, IFN-γ) and SLEDAI score were analyzed. 【Results】The percentage of ILC1 in the active group was higher, while levels of ILC2 and ILC3 were lower than those in the stable group and the control group (P<0.05).The percentage of ILC1 in the stable group was higher than that of the control group; and percentages of ILC2 and ILC3 in the active group were lower than those in the control group (P<0.05). The levels of C3 and IgG level in the active group were higher than those in the stable group and the control group, while the C4 level in the active group was lower than that in the control group (P<0.05). The level of IL-33 in the active group was lower, and levels of IL-4 and IFN-γ were higher than those in the stable group and the control group (P<0.05). The level of IL-4 in the stable group was lower than that in the control group (P<0.05). Correlation analysis showed that ILC2 was positively correlated with IL-4 (P<0.05) and ILC2 was negatively correlated with SLEDAI score (P<0.05). ILC3 was positively correlated with IL-4 (P<0.05). 【Conclusion】Patients with lupus nephritis have abnormal levels of immunity and ILC, and ILC2 is associated with disease activity. 2021 Vol. 38 (8): 1218-1220 [Abstract] ( 35 ) HTML (1 KB)  PDF (1168 KB)  ( 39 ) 1221 Effects of Micro Plate Internal Fixation and Cannulated Screw Internal Fixation on Ankle Joint Function and Inflammatory Response in Patients with Large Posterior Malleolus Fracture FENG Ji-qing, YAN Wei-jing DOI: 10.3969/j.issn.1671-7171.2021.08.030 【Objective】To investigate the clinical effect of internal fixation (micro plate and cannulated screw) on ankle function and inflammatory reaction in the treatment of large posterior malleolus fracture . 【Methods】From January 2017 to January 2019, 41 patients with massive posterior malleolus fractures were selected and divided into two groups according to the ball touch method: the observation group (n=21 cases) and the control group (n=20 cases). The observation group was treated with micro plate internal fixation, while the control group was treated with hollow nail internal fixation. The differences of clinical efficacy, clinical related indexes, postoperative complications and inflammatory indexes were compared between the two groups. The patients in the two groups were followed up for 12-13 months, and the changes of ankle function and mobility before and after treatment were compared. 【Results】All patients were followed up for an average of (12.5±0.2) months (range:12-13 months). The operation time of the control group was shorter than that of the observation group (P<0.05), however, the intraoperative blood loss was not significant between the observation group and the control group (P ＞ 0.05).The time of ambulation, fracture healing and full weight-bearing in the observation group were shorter than those in the control group (P<0.05).The excellent and good rate of the observation group was better than that of the control group (P<0.05).The total incidence of postoperative wound infection, delayed union of fracture, articular surface collapse and screw loosening in the observation group was lower than that in the control group (P<0.05). After 12 months, the ankle flexion and dorsiflexion activities of the two groups were significantly improved compared to before operation, the ankle valgus and varus activities of the two groups were significantly lower than before operation, and the ankle joint activity of the observation group was significantly better than that of the control group (P<0.05).The scores of AOFAS and KPS at 12 months after surgery were higher than before surgery; and AOFAS and KPS scores in the observation group were significantly higher than those in the control group (P<0.05).The levels of serum CRP, IL-6 and IL-8 on day 30 after operation in the two groups were significantly lower than those before operation, and the levels of serum CRP, IL-6 and IL-8 in the observation group were lower than those in the control group on day 30 after operation (P<0.05). 【Conclusion】Microplate internal fixation is more effective in the treatment of ankle mass fracture, its ankle function recovery is better and inflammation is less. 2021 Vol. 38 (8): 1221-1224 [Abstract] ( 38 ) HTML (1 KB)  PDF (1183 KB)  ( 30 ) 1225 Effects of Long-term Exposure to Atmospheric Particulate Matter on the Risk of Chronic Kidney Disease HAO Jie, LIANG Hui, QU Jian-liang DOI: 10.3969/j.issn.1671-7171.2021.08.031 【Objective】To investigate the effect of long-term exposure to atmospheric particulates on the risk of chronic kidney disease (CKD). 【Methods】A total of 1378 patients who participated in the health examination in our hospital's medical examination center were selected. PM2.5 concentrations were calculated based on aerosol optical depth (AOD) data using satellite-based space-time models. The estimated glomerular filtration rate (eGFR) level was calculated. CKD was defined as eGFR <60 mL/(min?1.73 m2). The general linear regression model was used to analyze the risk factors affecting eGFR. Multivariate Logistic regression was used to analyze the risk factors affecting CKD. 【Results】Of the 1378 patients, 103 cases had CKD, accounting for 7.47%. There were significant differences in age, smoking, drinking, body mass index (BMI), SBP, DBP, fasting blood glucose, and eGFR between the CDK group and non-CDK group(P<0.05). There was no significant difference in gender and education level in the two groups (P>0.05). Compared to the first quartile of PM2.5 group (the lowest PM2.5 concentration group), the eGFR levels of patients in the second, third, and forth quartiles were reduced [β(95%CI):-0.241(-0.307~-0.216), -0.283 (-0.321~-0.224), -0.346 (-0.493~-0.287),respectively]. For every 5 μg/m3 increase in PM2.5 concentration, eGFR decreases by 0.297(95%CI:0.216-0.336). Multivariate Logistic regression analysis showed that smoking, drinking, fasting blood glucose and PM2.5 were risk factors for CKD. 【Conclusion】Long-term exposure to PM2.5 is associated with an increased risk of CKD. Reducing air pollution can prevent the occurrence and development of CKD. 2021 Vol. 38 (8): 1225-1228 [Abstract] ( 37 ) HTML (1 KB)  PDF (1191 KB)  ( 36 ) 1229 Multivariate Analysis of the Relationship between Tp-Te Interval, Serum Phosphate Concentration and Prognosis of HFpEF Patients YU Yan-yan, WANG Wen-zhi, WU Cong DOI: 10.3969/j.issn.1671-7171.2021.08.032 【Objective】To investigate the correlation between T-peak to end interval (Tp-Te interval) of ECG, serum phosphate level and the prognosis of patients with ejection fraction preserved heart failure (HFPEF). 【Methods】 A total of 98 patients with HFPEF treated in our hospital from January 2018 to March 2020 were divided into observation group (poor prognosis, mace, n=20) and control group (good prognosis, no mace, n=78). The levels of serum phosphate, NT-proBNP and cardiac function were compared between the two groups, and the risk factors of mace in patients with HFPEF were analyzed. 【Results】 The Tp-Te interval in the observation group was longer than that in the control group, and the levels of serum phosphate and NT-proBNP were significantly higher than those in the control group (P<0.05). VST and LVPWT in the observation group were significantly higher than those in the control group (P<0.05); There was no significant difference in LVEF and LVEDd between the two groups (P>0.05). Pearson correlation analysis showed that Tp-Te interval was positively correlated with NT- proBNP, VST and LVPWT (r=0.333, 0.356 and 0.329, Mean P<0.05), and serum phosphate concentration was positively correlated with NT-proBNP (r=0.350, P<0.05). Logistic regression analysis showed that long Tp-Te interval, high serum phosphate level and VST were the risk factors for MACE in patients with hfpee (OR=1.406, 1.426, 1.603, Mean P<0.05). 【Conclusion】 Too long Tp-Te interval, too high serum phosphate level and too thick VST are the risk factors of MACE in patients with HFpEEh. These patients should be given timely and effective treatment measures to reduce the incidence of MACE. 2021 Vol. 38 (8): 1229-1231 [Abstract] ( 47 ) HTML (1 KB)  PDF (1165 KB)  ( 30 ) 1232 Expression and Clinical Significance of miR-449a in Lung Cancer Tissue LI Mei-Ling, ZHANG Guang-Ying DOI: 10.3969/j.issn.1671-7171.2021.08.033 【Objective】To investigate the expression of microrna-449a (miR-449a) in lung cancer and its clinical significance.【Methods】 The specimens of cancer tissues and their corresponding adjacent tissues from 108 patients with lung cancer confirmed by pathology were collected, and the expression of miR-449a was detected by real-time quantitative polymerase chain reaction (RT-PCR) to determine the correlation between the expression of miR-449a in lung cancer and clinicopathological features and prognosis of lung cancer patients.【Results】 The expression of miR-449a in lung cancer was significantly lower than that in adjacent tissues (P<0.05); The expression level of miR-449a was significantly correlated with clinical stage and lymph node metastasis (P<0.05). The median survival time of high expression of miR-449a was higher than that of low expression (P<0.05).【Conclusion】 The expression of mir-449a is low in lung cancer. The expression of mir-449a is closely related to clinical stage, lymph node metastasis and prognosis. 2021 Vol. 38 (8): 1232-1234 [Abstract] ( 48 ) HTML (1 KB)  PDF (1278 KB)  ( 24 )

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