长期暴露于大气颗粒物对慢性肾脏病发病风险的影响

doi:10.3969/j.issn.1671-7171.2021.08.031

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Abstract 【Objective】To investigate the effect of long-term exposure to atmospheric particulates on the risk of chronic kidney disease (CKD). 【Methods】A total of 1378 patients who participated in the health examination in our hospital's medical examination center were selected. PM_2.5 concentrations were calculated based on aerosol optical depth (AOD) data using satellite-based space-time models. The estimated glomerular filtration rate (eGFR) level was calculated. CKD was defined as eGFR <60 mL/(min?1.73 m²). The general linear regression model was used to analyze the risk factors affecting eGFR. Multivariate Logistic regression was used to analyze the risk factors affecting CKD. 【Results】Of the 1378 patients, 103 cases had CKD, accounting for 7.47%. There were significant differences in age, smoking, drinking, body mass index (BMI), SBP, DBP, fasting blood glucose, and eGFR between the CDK group and non-CDK group(P<0.05). There was no significant difference in gender and education level in the two groups (P>0.05). Compared to the first quartile of PM_2.5 group (the lowest PM_2.5 concentration group), the eGFR levels of patients in the second, third, and forth quartiles were reduced [β(95%CI):-0.241(-0.307~-0.216), -0.283 (-0.321~-0.224), -0.346 (-0.493~-0.287),respectively]. For every 5 μg/m³ increase in PM_2.5 concentration, eGFR decreases by 0.297(95%CI:0.216-0.336). Multivariate Logistic regression analysis showed that smoking, drinking, fasting blood glucose and PM_2.5 were risk factors for CKD. 【Conclusion】Long-term exposure to PM_2.5 is associated with an increased risk of CKD. Reducing air pollution can prevent the occurrence and development of CKD.

Key words： Kidney Diseases/ET Chronic Disease Particulate Matter

Received: 15 January 2021

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R692

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	HAO Jie
	LIANG Hui
	QU Jian-liang

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HAO Jie,LIANG Hui,QU Jian-liang. Effects of Long-term Exposure to Atmospheric Particulate Matter on the Risk of Chronic Kidney Disease[J]. JOURNAL OF CLINICAL RESEARCH, 2021, 38(8): 1225-1228.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2021.08.031 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2021/V38/I8/1225

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