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Quick Search     Adv Search 2019 Vol. 36, No. 8 Published: 2019-08-30   1457 Expression of IL-22 of the from Peripheral Blood Mononuclear Cells in Patients with Rheumatic Heart Disease DUAN Chang-en, SU Guo-bao, ZHOU Chao-yuan,et al DOI: 10.3969/j.issn.1671-7171.2019.08.001 【Objective】To investigate the expression and significance of the interleukin-22 that secreted by the peripheral blood mononuclear cells from the patients with rheumatic heart disease (RHD) to provide theoretical basis for the clinical treatment. 【Methods】A total of 30 patients with RHD who underwent surgery from May 2016 to May 2017 were selected as the observation group and 30 healthy blood donors were selected as the control group. Peripheral blood mononuclear cells from patients with rheumatic heart disease and healthy donors were isolated by density gradient centrifugation. The content and gene expression of IL-22 in the culture medium were detected using ELISA and qRT-PCR, respectively. At the same time, the cellular morphology of peripheral blood mononuclear were observed by scanning electron microscope after co-cultured with the culture medium from patients with rheumatic heart disease . 【Results】The content and gene expression of IL-22 in the culture medium of patients with rheumatic heart disease were significantly higher than those in healthy donors. The differences were statistically significant(P＜0.05). The morphology of peripheral blood mononuclear cells from healthy donors showed dramatically changed even collapsed and ruptured when they co-cultured with the secreted medium from RHD patients' mononuclear cells.. 【Conclusion】The over-expression of IL-22 of the peripheral blood mononuclear cells from patients with rheumatic heart disease plays a certain role in the occurrence and development of the disease RHD. 2019 Vol. 36 (8): 1457-1459 [Abstract] ( 222 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 1460 Relationship between Severity of Actual Upper Respiratory Infection and Content of Interleukin-8 and Neutrophil in Nasal Lavage XIANG Yuan-cheng DOI: 10.3969/j.issn.1671-7171.2019.08.002 【Objective】To explore the correlation between the severity of acute upper respiratory infection and the content of interleukin-8 (IL-8) and neutrophils in nasal lavage fluid. 【Methods】A total of 784 patients with acute upper respiratory tract infection were included and the contents of IL-8 and neutrophils in nasal lavage fluid were detected. The severity of upper respiratory tract infection was assessed by the Wisconsin wurss-21 survey. According to wurss-21 scores, the patients were divided into three groups: mild, moderate and severe. The content of IL-8 and neutrophils from the three groups were compared, and their relationship with the severity of acute upper respiratory tract infection was also conducted. 【Results】Of 784 patients, 137 were mild, 339 were moderate, and 308 were severe. The content of Il-8 and neutrophils were positively correlated with the severity of acute upper respiratory tract infection. Correlation analysis showed that IL-8 and neutrophils were significantly positively correlated with the severity of acute upper respiratory tract infection (r=0.32, P=0.001; r=0.28, P=0.002). Il-8 and neutrophils were associated with nasal symptom severity of acute upper respiratory tract infection symptoms, including running nose (r=0.13,P=0.001;r=0.18,P=0.003), nasal obstruction (r=0.15,P=0.003; r=0.14,P=0.028), sneezing (r=0.02,P=0.001;r=0.01,P=0.031)and hoarseness (r=0.02,P= 0.017); r=0.03,P=0.034). 【Conclusion】Il-8 and neutrophils are associated with the severity of nasal symptoms during acute respiratory infection. Thus can be used as a monitoring indicator for the severity of acute upper respiratory tract infections. 2019 Vol. 36 (8): 1460-1461 [Abstract] ( 157 ) HTML (1 KB)  PDF  (0 KB)  ( 14 ) 1462 Study on the Status of Postoperative Recovery Quality after Day Surgery CHEN Cheng, DU Jiao-jiao, SONG Ying-han DOI: 10.3969/j.issn.1671-7171.2019.08.003 【Objective】To investigate the status of postoperative recovery quality of patients undergoing day surgery, and to analyze the relevant factors affecting the quality of postoperative recovery. 【Methods】 A total of 372 patients who underwent laparoscopic cholecystectomy (day surgery) in our hospital from August 2017 to October 2018 were randomly divided into two groups: day operation group(D Group) and elective operation group(E Group), with 186 patients in each group. The operation time and bleeding volume were compared between the two groups. The quality of postoperative recovery was assessed by 15 items of Quality of Recovery Questionnaire 15 (QoR-15). Multivariate regression analysis was used to summarize the related factors affecting the QoR-15 score in the D group. 【Results】 The operations were successfully completed in both groups without conversion to laparotomy. The hospitalization time and hospitalization expenses in the D group were lower than those in the E group, and the difference was statistically significant (P<0.05). The QoR-15 scores on 1st day after discharge in the two groups were higher than those on d1 post-operation, and the QoR-15 scores of the two groups of 2 weeks after discharge were higher than those of the 1st day after discharge (P<0.05). However, there were no significant differences in the QoR-15 scores between the two groups at the same time points (P>0.05). The QoR-15 score of male patients in the D group was (106.72±9.31) on the 1st day after discharge, which was higher than that of female patients (90.59±8.71). The difference was statistically significant (P<0.05). Multivariate regression analysis showed that age, BMI and operation time were all correlated with QoR-15 score of 1st day after discharge. The correlation equation was QoR-15 score Y=117.03-0.0571X(age)-0.1905X(operation time)-0.4326X(BMI). 【Conclusion】 As far as laparoscopic cholecystectomy is concerned, the quality of recovery after day operation is similar to that of the elective operation, and the hospitalization time of patients is shorter and the cost of hospitalization is lower than the elective operation. Gender, age, BMI and operation time can affect the quality of recovery after operation, which should be paid attention to. 2019 Vol. 36 (8): 1462-1465 [Abstract] ( 195 ) HTML (1 KB)  PDF  (0 KB)  ( 15 ) 1466 Effect of tubeless PCNL in the Treatment of Incarcerated Upper Ureteral Calculi and its Influence on Serum Inflammatory Factors FU Shi-bao, XIAO Jing-zhu, HE Shu-ming, et al DOI: 10.3969/j.issn.1671-7171.2019.08.004 【Objective】To investigate the effect of tubeless percutaneous nephrolithotomy (PCNL) in the treatment of incarcerated upper ureteral calculi and its influence on serum inflammatory factors. 【Methods】The clinical data of 120 patients with incarcerated upper ureteral calculi in our hospital were selected and divided into observation group (tubeless PCNL operation) and control group (retroperitoneal laparoscopic operation), 60 cases each. The operation time, intraoperative bleeding volume, hospital stay, duration of hematuria and stone clearance rate, serum levels of interleukin-2 (IL-2), interleukin-6 (IL-6), prostaglandin E2 (PGE2) and tumor necrosis factor- α (TNF-α) before and after operation were compared between the two groups. 【Results】The operation time, intraoperative bleeding volume and hospitalization time of the observation group were lower than those of the control group, and the duration of naked hematuria after operation was longer than that of the control group (P<0.05). The stone clearance rate of the control group was 100.00% (60/60), while that of the observation group was 93.33% (56/60) and 98.33% (59/60), respectively, with no significant difference (P>0.05). The incidence of postoperative complications in the observation group was 5.00% (3/60) lower than that in the control group 16.67% (10/60). The difference was statistically significant (χ2=4.227,P=0.04<0.05). 24 hours after operation, the serum levels of IL-6, PGE2 and TNF-alpha in the observation group were lower than those in the control group (P<0.05), and the serum levels of IL-2 were higher than those in the control group (P<0.05).【Conclusion】The stone clearance rate of tubeless PCNL in the treatment of incarcerated upper ureter calculi is not significantly different from that of retrolaparoscopic surgery, but the trauma is smaller, the postoperative recovery is faster, the complications are fewer, and the degree of inflammatory reaction is less. 2019 Vol. 36 (8): 1466-1468 [Abstract] ( 130 ) HTML (1 KB)  PDF  (0 KB)  ( 20 ) 1469 A Follow-up Study of Laparoscopic Pyeloplasty for Ureteropelvic Junction Obstruction Complicated with Severe Hydronephrosis CHEN Yao-yao, HE Jun, TANG Yuan-hui,et al DOI: 10.3969/j.issn.1671-7171.2019.08.005 【Objective】To investigate the efficacy and long-term effects of laparoscopic ureteropelvic angioplasty for ureteropelvic junction obstruction with severe hydronephrosis. 【Methods】A total of 80 patients with ureteropelvic junction obstruction (UPJO) complicated with severe hydronephrosis were enrolled in our hospital from January 2015 to January 2017. According to different surgical methods, patients were divided into the observation group (laparoscopic application) and the control group (traditional open surgery), with 40 cases in each group. The experimental group was treated with laparoscopic ureteral ureteral dissection and the control group was treated with open ureteral ureteral dissection. The intraoperative blood loss, operation time, perirenal drainage, days of drainage tube, hospitalization days, hospitalization costs, and surgical complications were observed. Symptom relief of obstruction and recurrence of hydronephrosis were followed up for 2~24 months. 【Results】 The operation time, intraoperative blood loss, perirenal drainage volume, extubation days and postoperative hospitalization in the observation group were significantly lower than those in the control group (P<0.05). However, the hospitalization expenses of the observation group were significantly higher than those of the control group; the differences were statistically significant (P<0.05). The postoperative complication rates of the observation group was 7.5% (3/40) , which seemed lower than 10% (4/40), while the difference was not statistically significant (χ2=0.157,P=0.692>0.05). The study was followed up for 2~24 months. Patients with waist and abdominal pain in both groups before surgery were relieved or disappeared after surgery. All patients had no recurrence of obstruction. The conditions of renal pelvis and ureteral drainage, hydronephrosis, and kidney function were significantly improved. 【Conclusion】Laparoscopic ureteral ureteral dissection is effective in the treatment of ureteropelvic junction obstruction with severe hydronephrosis. The long-term results are satisfactory and can be promoted. 2019 Vol. 36 (8): 1469-1471 [Abstract] ( 149 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 1472 Effect of Erlotinib and Pemetrexed on Late Stage of NSCLC Patients with Failure of First-line Standard Chemotherapy HE Zhi-hui, LU Yan-da, HUANG Fen,et al DOI: 10.3969/j.issn.1671-7171.2019.08.006 【Objective】To analyze the efficacy of erlotinib and pemetrexed in patients with advanced non-small cell lung cancer (NSCLC) who failed first-line standard chemotherapy regimen. 【Methods】A total of 90 patients with advanced NSCLC were divided into two groups according to the order of admission. Group A was treated with oral erlotinib 150mg/d and group B was treated with pemetrexed 500mg/m2 intravenously. The clinical effects of the two groups were analyzed. 【Results】The total effective rate and disease control rate between the two groups were not significantly different (P>0.05). There were no significant differences in the levels of carbohydrate antigen 50 (CA50) and cytokeratin 19 fragment (CYFRA21-1) between the two groups before treatment (P>0.05). After treatment, the levels of CA50 andCYFRA21-1 in each group were lower than those before treatment (P<0.05). However, there were no significant differences between the two groups after treatment (P>0.05). The overall quality of life in group A was better than that in group B (P<0.05). The main adverse reactions in group A were rash and diarrhea, while in group B, bone marrow suppression and gastrointestinal reaction were the main side effects. There was significant difference in the incidence of adverse reactions between the two groups (P<0.05). 【Conclusion】The efficacy of erlotinib and pemetrexide in the treatment of advanced NSCLC with failure of the first-line standard chemotherapy regimen is similar. They both can reduce the levels of tumor markers. Erlotinib has obvious advantage in improving the quality of life. 2019 Vol. 36 (8): 1472-1474 [Abstract] ( 107 ) HTML (1 KB)  PDF  (0 KB)  ( 19 ) 1475 Correlation between Survivin Acetylation and PCAF Expression in Esophageal Carcinoma and its Clinical Significance LIANG Zong-ying, HOU Ji-shen, ZHANG Le,et al DOI: 10.3969/j.issn.1671-7171.2019.08.007 【Objective】To investigate the relationship between the acetylation level of Survivin protein and the expression of P300/CBP-related factor (PCAF) and its clinicopathological features in esophageal cancer. 【Methods】The acetylation of Survivin protein in 90 cases of esophageal carcinoma and adjacent normal esophageal epithelial tissues was detected by immunoprecipitation and Western blot. The expression of PCAF in esophageal carcinoma was detected by immunohistochemical staining, and the relationship between Survivin protein acetylation and clinicopathological features and the expression of PCAF protein was analyzed.【Results】The acetylation rate of Survivin protein in esophageal cancer tissues was (72.67±1.25)%, significantly higher than that in normal esophageal tissues adjacent to cancer (11.18±2.16)% (P<0.05). The acetylation level of Survivin protein in esophageal cancer tissues was closely related to TNM stage, tissue differentiation and lymph node metastasis (P<0.05). The positive expression of Survivin was 28.89%, which was significantly lower than 92.22% in normal esophageal tissues (P<0.05). There was no correlation between the acetylation level of Survivin protein and PCAF level in esophageal cancer tissues (P>0.05). 【Conclusion】Survivin protein acetylated in esophageal cancer tissue, and the occurrence and development of esophageal cancer may be closely related to the degree of acetylation of Survivin protein; Survivin protein acetylation and acetyltransferase PCAF have no correlation. 2019 Vol. 36 (8): 1475-1477 [Abstract] ( 118 ) HTML (1 KB)  PDF  (0 KB)  ( 14 ) 1478 Changes of sICAM-1, P- selectin and D-dimer Associating with the Severity of Acute Pancreatitis ZHANG Ling, HUANG Yin, YANG Ting-ting DOI: 10.3969/j.issn.1671-7171.2019.08.008 【Objective】To investigate the changes of serum sICAM-1, P-selectin and D-dimer(D-D) levels in patients with acute pancreatitis and their relationship with the severity of the disease. 【Methods】Patients with mild pancreatitis (MAP,n=36) and severe pancreatitis (SAP,n=44) plus 25 healthy people (control group) were selected for the study. On day 1 (d1) and day 7 (d7) of hospital admission, venous blood was collected to detect sICAM-1, P-selectin and D-D . The changes and correlations of each index in the three groups were analyzed. 【Results】On the first day of admission, the levels of sICAM-1, P-selectin and D-D in all subjects were SAP group >MAP group>control group (P<0.05). On d7, the levels of sICAM-1 and P-selectin in the MAP group and SAP group were significantly lower than those on d1 (P<0.05), while the D-D level was higher than that of d1 (P<0.05).Furthermore, the levels of P-selectin and sICAM-1 in the MAP group were significantly lower than those in the SAP group (P<0.05), while the level of D-D were the opposite (P<0.05). Pearson or Spearman correlation analysis showed that sICAM was positively correlated with P-selectin and D-D (P<0.01) and P-selectin was positively correlated with D-D (P<0.01) on d1 and d7. 【Conclusion】The changes of sICAM-1, P-selectin and D-D are closely related to the occurrence and development of acute pancreatitis, which can be used as biological indicators for evaluating the condition of patients with acute pancreatitis. 2019 Vol. 36 (8): 1478-1479 [Abstract] ( 101 ) HTML (1 KB)  PDF  (0 KB)  ( 14 ) 1480 Significance of Serum Superoxide Dismutase, C-reactive Protein, Homocysteine and Cystatin C in Patients with Gestational Diabetes Mellitus GAO Jiao, XIAO Min, LI Dan, et al DOI: 10.3969/j.issn.1671-7171.2019.08.009 【Objective】To explore the changes of serum superoxide dismutase (SOD), C-reactive protein (CRP), homocysteine (Hcy) and cystatin C (Cys-C) in patients with gestational diabetes mellitus (GDM). 【Methods】A total of 20 GDM patients (GDM group) who were admitted to our hospital from March to August 2018 were selected. Twenty-four normal pregnant women in the same period were selected as normal pregnancy group (control group). The levels of serum FPG (fasting blood glucose), SOD, CRP, Hcy, Cys-C , FINS, HOMA-IR, HOMA-beta of the two groups were detected and compared. The correlation between SOD, CRP, Hcy, Cys-C and HOMA-IR, HOMA-beta was analyzed. 【Results】The levels of FPG, CRP, Hcy, HOMA-IR and Cys-C in the GDM group were significantly higher than those in normal pregnancy control group (P<0.05). The level of SOD in the normal pregnancy group was higher than that in the GDM group, the difference was statistically significant (P<0.05). There was no significant difference in HOMA-beta between the two groups (P>0.05). HOMA-IR was positively correlated with CRP, Hcy and Cys-C in the GDM group, while HOMA-IR was negatively correlated with SOD (P<0.05).However, HOMA-IR had no significant correlation with HOMA-β (P>0.05). 【Conclusion】The occurrence of gestational diabetes mellitus leads to the changes of serum SOD, CRP, Hcy and Cys-C levels. The levels of serum CRP, Hcy and Cys-C in GDM pregnant women were significantly increased, while SOD was significantly decreased. HOMA-IR was positively correlated with CRP, Hcy and Cys-C, and negatively correlated with SOD. These indicators can be used as a dynamic detection index for gestational diabetes mellitus patients. 2019 Vol. 36 (8): 1480-1482 [Abstract] ( 115 ) HTML (1 KB)  PDF  (0 KB)  ( 17 ) 1483 Evaluation of Combined Detection of Serum Exosomes miR-301a, miR-205, miR-376a and miR-222 in Early Diagnosis of Glioma ZHENG Zhong-tao, ZHU Ye, LI Xia DOI: 10.3969/j.issn.1671-7171.2019.08.010 【Objective】To investigate the early diagnostic value of combined detection of serum exosomes miR-301a, miR-205, miR-376a and miR-222 in glioma. 【Methods】 Sixty patients with early glioma admitted to our hospital from January 2016 to January 2019 were included in the observation group and 60 healthy volunteers in the same period were selected as the control group. The relative expression levels of serum exosomes miR-301a, miR-205, miR-376a, and miR-222 were measured in the two groups. The diagnostic value of serum exosome miR-301a, miR-205, miR-376a and miR-222 for early gliomas was detected by AUC of receiver operating characteristic curve (ROC). 【Results】The relative expression levels of serum exosomes miR-301a and miR-222 in patients with early glioma were significantly higher than those of healthy subjects (P<0.05). The relative expression levels of serum exosomes miR-205 and miR-376a in patients with early glioma were significantly lower than those of healthy subjects (P<0.05). The sensitivity of one-way diagnosis of serum exosomes miR-301a, miR-205, miR-376a or miR-222 in patients with early glioma and healthy people was 83%, 72%, 83% and 87%, respectively. The specificity were 83%, 73%, 83% and 87%, respectively. The sensitivity of the combination of serum exosomes miR-301a, miR-205, miR-376a and miR-222 for the diagnosis of early glioma was 85.00%, the specificity was 86.67%, and the accuracy was 85.83%.【Conclusion】The combined detection of the relative expression levels of serum exosomes miR-301a, miR-205, miR-376a and miR-222 provides high diagnostic value, which can be used as potential marker for the diagnosis of early glioma. 2019 Vol. 36 (8): 1483-1485 [Abstract] ( 114 ) HTML (1 KB)  PDF  (0 KB)  ( 15 ) 1486 Efficacy of Salvia Miltiorrhiza Ligustrazine and Butylphthalide Injection on Angiotensin Ⅱ, Brain Natriuretic Peptide and Chemerin Factor in Patients with Acute Ischemic Stroke LI Yong-feng, LI Wei, WANG Deng-qin, et al DOI: 10.3969/j.issn.1671-7171.2019.08.011 【Objective】To investigate the effect of salvia miltiorrhiza ligustrazine and butylphthalide injection on angiotensin Ⅱ (Ang Ⅱ), brain natriuretic peptide (BNP) and adipokinin factor (chemerin) in patients with acute ischemic stroke. 【Methods】A total of 302 patients with acute ischemic stroke were randomly divided into the control group (treated with salvia miltiorrhiza ligustrazine injection, n=151) and the observation group (salvia miltiorrhiza ligustrazine + butylphthalide injection, n=151). After 2 weeks of continuous treatment, the NIHSS score was used to observe the neurological function of the patients. The serum levels of BNP, Ang Ⅱ, MDA (malondialdehyde), SOD (superoxide dismutase) and Chemerin were detected by enzyme linked immunosorbent assay.【Results】 The levels of serum BNP, Ang Ⅱ, Chemerin, BNP and MDA in the two groups were lower than those before treatment, and the SOD level was higher than that before treatment.The difference between the two groups was statistically significant (P<0.05). The NIHSS scores of the two groups were lower than those before treatment, and the difference between the two groups was statistically significant (P<0.05). The two groups were followed up with for 2 months. The incidence of poor prognosis in the observation group was 3.31% (5/151), which was lower than 9.93% (15/151) in the control group. The difference was statistically significant (χ2=5.355,P=0.021<0.05). 【Conclusion】The salvia miltiorrhiza ligustrazine combined with butylphthalide injection can obviously improve the neurological function of the patients with acute ischemic stroke, and the prognosis is better. It may be related to reducing the level of plasma BNP and MDA, Chemerin, alleviating the inflammatory reaction and improving the body's antioxidant capacity. 2019 Vol. 36 (8): 1486-1488 [Abstract] ( 112 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 1489 Expression of PTX3 Gene in Endometrial Carcinoma Cells DU Wei, SHAO Shu-juan, HAO Yuan-yuan DOI: 10.3969/j.issn.1671-7171.2019.08.012 【Objective】To investigate the effects of PTX-3 gene expression on cell cycle regulation, proliferation, migration and invasion of endometrial cancer cells. 【Methods】By designing and synthesizing PTX3-specific siRNA, control plasmid and empty vector, HEC-1-A cells were transfected as PTX3-siRNA group, NC-siRNA group and Blank group, respectively. The expression of PTX3 mRNA in transfected cells was detected by RT-PCR. The cell cycle was analyzed by flow cytometry and the cell proliferation activity was measured by MTT assay. The scratch assay was used to reflect cell migration ability, and the Transwell chamber assay was applied to evaluate cell invasion ability. 【Results】The expression of PTX3 mRNA in PTX3-siRNA group was significantly lower than that in NC-siRNA group and Blank group (P<0.05). The proportion of cells in G1 phase in PTX3-siRNA group was significantly higher than that in NC-siRNA group and Blank group (P<0.05), while the proportion of S phase cells in PTX3-siRNA group was significantly lower than that of the NC-siRNA group and the Blank group (P<0.05). The cell proliferation ability, cell migration ability and the number of transmembrane cells in PTX3-siRNA group were significantly lower than those in the NC-siRNA group and the Blank group (P<0.05).【Conclusion】 Down-regulation of PTX3 gene expression may impede the progression of endometrial cancer cell cycle and inhibit cell proliferation, migration and invasion. 2019 Vol. 36 (8): 1489-1491 [Abstract] ( 113 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 1492 Efficacy and Safety of Single-port Thoracoscopic Parietal Pleural Resection in the Treatment of Pulmonary Bullae CHEN Feng-zhong, ZHANG Jiang DOI: 10.3969/j.issn.1671-7171.2019.08.013 【Objective】To study the efficacy and safety of single-port thoracoscopic parietal pleural resection in the treatment of pulmonary bullae.【Method】A total of 100 patients with pulmonary bullae in our hospital from February 2015 to February 2018 were selected as the study subjects.According to the random number table method, the patients were divided into observation group and control group, 50 cases each.The control group was treated with single-hole thoracoscopy for bullae, while the observation group was treated with single-hole thoracoscopy for bullae.The perioperative indexes such as operation time, hospital stay, drainage volume, time to get out of bed, recovery time, feeding time and anesthetic effect were compared between the two groups.In addition, the levels of CRP, IL-6, IL-8, TNF-alpha, FT3, FT4 and COR were compared between the two groups before operation, 1 and 2 weeks after operation.The incidence of complications and recurrence rate were observed.The changes of respiratory function before and after operation were compared between the two groups.【Result】The operation time, hospitalization time, drainage volume, time to get out of bed, recovery time and eating time of the observation group were significantly lower than those of the control group (P<0.05).The CRP, IL-6, IL-8, TNF-a, FT3, FT4 and COR in the observation group were significantly lower than those in the control group at 1 and 2 weeks after operation (P<0.05).The total incidence of complications in the two groups was significantly lower than that in the control group (P<0.05).There was no significant difference in recurrence rate between the two groups (P>0.05).The respiratory rate and PaCO2 of the two groups at 1 and 2 weeks after operation were lower than those before operation, and the PaO2 was higher than that before operation,the difference were statistically significant (P<0.05).The respiratory rate and PaCO2 at 1 and 2 weeks after operation in the observation group were lower than those in the control group, and the PaO2 was higher than that in the control group,the difference were statistically significant (P<0.05).【Conclusion】Single-port thoracoscopic parietal pleural resection is effective in the treatment of pulmonary bullae. Compared with traditional laparoscopic surgery, it can reduce the risk of complications, and is helpful for early recovery of respiratory function after operation with higher clinical value. 2019 Vol. 36 (8): 1492-1494 [Abstract] ( 119 ) HTML (1 KB)  PDF  (0 KB)  ( 12 ) 1495 Association between Polymorphism of Tumor Necrosis Factor-inducible Protein 3 Gene and Genetic Susceptibility to Allergic Rhinitis LIANG Rong-fang DOI: 10.3969/j.issn.1671-7171.2019.08.014 【Objective】To investigate the relationship between gene polymorphism of tumor necrosis factorαinduced protein 3 (TNFAIP3) and genetic susceptibility to allergic rhinitis (AR).【Methods】From January 2016 to August 2017, the blood samples of 200 patients with AR (observation group) and 200 healthy volunteers (control group) were selected as the subjects.Four polymorphism loci (rs5029928,rs9494885,rs610604,rs7753873) of TNFAIP3 gene in DNA samples extracted from anticoagulant were genotyped by restriction fragment length polymorphism polymerase chain reaction (PCR-RFLP) and direct sequencing.【Results】The genotypes of four polymorphic loci of TNFAIP3 gene in both groups were in accordance with Hardy Weinberg equilibrium, and there were significant differences in allele and genotype frequencies of rs94885 locus between the two groups. The frequency of ACA haplotype in the observation group was significantly lower than that in the control group (P<0.05), and the frequency of TCCA haplotype was significantly higher than that in the control group (P<0.05). There was no significant difference in other indicators between the two groups (P>0.05).【Conclusion】There is a significant correlation between AR and TNFAIP3 gene polymorphism, and the rs94885 polymorphism of TNFAIP3 is closely related to AR susceptibility. 2019 Vol. 36 (8): 1495-1497 [Abstract] ( 89 ) HTML (1 KB)  PDF  (0 KB)  ( 14 ) 1498 Expression and Significance of ERα and ERβ in Decidua of Premature Women with Intact Fetal Membranes YANG Yu-jiao, SHEN Xiao-jun, ZHANG Shu-xuan DOI: 10.3969/j.issn.1671-7171.2019.08.015 【Objective】To investigate the expression and significance of estrogen receptor α (ER α)and estrogen receptor β(ER β) in decidual tissue of premature parturients with intact membranes.【Methods】 20 parturients with complete premature delivery, 20 parturients with full term parturition (positive control group) and 20 parturients without birth sign (negative control group) were selected ,and the expression of ERαand ERβin decidua of the three groups were detected by immunohistochemistry.【Results】The expression rate of ER α in decidua of complete premature delivery group and term parturient group was significantly higher than that of full-term parturient group (P<0.05), and the expression rate of ER β in decidual tissue of complete premature delivery group and term parturient group was significantly lower than that of full-term parturient group (P<0.05), and the expression rate of ER β in decidual tissue of the complete premature delivery group and the full-term parturient group was significantly lower than that of the full-term parturient group (P<0.05). However, there was no significant difference in the positive expression rates of ER α and ER β in decidua between the complete premature delivery group and the term parturient group (P>0.05).【Conclusion】The increase of ER α expression and the decrease of ER β expression in decidual tissue of parturients with complete premature delivery may be one of the causes of premature delivery. 2019 Vol. 36 (8): 1498-1500 [Abstract] ( 105 ) HTML (1 KB)  PDF  (0 KB)  ( 12 ) 1501 Expression and Significance of PTH, 1,25-(OH)2D3 in Patients with Chronic Heart Failure WU Man, PAN Chao, LIU Li-tan DOI: 10.3969/j.issn.1671-7171.2019.08.016 【Objective】To investigate the expression and significance of serum parathyroid hormone (PTH) and 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] in patients with chronic heart failure (CHF). 【Methods】One hundred and twenty-three patients with CHF were divided into two groups according to cardiac function grading:Ⅰ~Ⅱ and Ⅲ~Ⅳ. The levels of PTH and 1,25-(OH)2D3 in serum were compared, and the relationship between PTH and cardiac function grading and the effectiveness of diagnostic grading were analyzed.【Results】The level of serum PTH in patients with grade III-IV cardiac function was significantly higher than that in patients with grade Ⅲ~Ⅳ cardiac function, and the level of 1,25-(OH)2D3 was significantly lower than that in patients with grade I-II cardiac function (P<0.05); the combined evaluation of PTH and 1,25-(OH)2D3 cardiac function was more effective than any single index; univariate analysis showed that age (>60 years old), hypertension, stroke, cardiac function grade Ⅲ~Ⅳ, serum creatinine, and serum creatinine were higher than any single index Cholesterol, LDL-C, PTH, HDL-C and 1,25-(OH)2D3 were associated with the prognosis of C HF patients.with 1,25-(OH)2D3, and HDL-C was positively correlated with 1,25-(OH)2D3 (P<0.05). Multivariate analysis showed that grade Ⅲ~Ⅳ, high PTH, low HDL-C and 1,25-(OH)2D3 were independent risk factors for poor prognosis of CHF patients; PTH was positively correlated with grade of cardiac function, HDL-C and 1,25-(OH)2D3 were negatively correlated with grade of cardiac function; PTH was negatively correlated with 1,25-(OH)2D3, while HDL-C was positively correlated with 1,25-(OH)2D3 (r=0.682, P<0.05). Conclusion PTH, 1,25-(OH)2D3 were correlated with cardiac function grading in CHF patients and are risk factors for poor prognosis.【Conclusion】PTH, 1,25-(OH)2D3 are associated with cardiac function grading in CHF patients and are risk factors for poor prognosis. 2019 Vol. 36 (8): 1501-1503 [Abstract] ( 78 ) HTML (1 KB)  PDF  (0 KB)  ( 12 ) 1504 Analgesic Effect of Different Doses of Dexmedetomidine on Elderly Patients after Laparoscopic Radical Gastrectomy HUANG Xue-mei, WEI Fu-sheng, FENG Hai-xia DOI: 10.3969/j.issn.1671-7171.2019.08.017 【Objective】To investigate the effect of different doses of dexmedetomidine(Dex) on analgesia in elderly patients undergoing laparoscopic radical gastrectomy(LAP).【Methods】 A total of 120 elderly gastric cancer patients with LAP who received Dex for analgesia were random divided into low-dose group (group A) and high-dose group (group B), with 60 cases in each group. Both groups were injected with 0.5 μg/kg Dex before induction of anesthesia. Different doses of Dex were given intraoperatively for analgesia.Patients in group A received 0.5 μg/(kg·h) pump, and patients in group B received 1.0μg/(kg·h) Dex pump. VAS was used to evaluate the pain degree before operation (T0), immediately after operation (T1), 6 h after operation (T2), 12 h after operation (T3), 24 h after operation (T4), 48 h after operation (T5) and 72 h after operation (T6).Serum cortisol (Cor),adrenaline (E) and norepinephrine (NA) levels were measured before and 72 h after operation, and adverse reactions were recorded.【Results】The VAS scores of T1, T2, T3, T4, T5 and T6 in the two groups were lower than those of T0 (P<0.05), and the VAS scores of T5 and T6 in the two groups were lower than those of T1, T2, T3 and T4(P<0.05).The VAS scores of T1, T2, T3, T4, T5 and T6 in group B were lower than those in group A, and there were significant differences between the two groups (P<0.05). Serum levels of Cor, E and NA at 72 h after operation in the two groups were higher those before operation(P<0.05), and those in group B were lower than group A (P<0.05).There was no significant difference in the incidence of adverse reactions between the two group (P>0.05).【Conclusion】Compared to 0.5 μg/(kg·h) Dex, high dose of Dex [1.0μg/(kg·h)]not only achieves better analgesic effect, but also reduces post-operative stress response without increasing the risk of adverse reactions. 2019 Vol. 36 (8): 1504-1506 [Abstract] ( 112 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 1507 Correlation of BRAF V600E Mutation and Microsatellite Instability with Prognosis in Colorectal Cancer Patients HE Xing-zhuang, YANG Zheng-bing, MOU Hui DOI: 10.3969/j.issn.1671-7171.2019.08.018 【Objective】To investigate the relationship of microsatellite instability (MSI) and BRAF V600E mutation with clinicopathological features and prognosis of patients with advanced stages of colorectal cancer (CRC). 【Methods】A total of 82 patients with radical resection of colorectal cancer admitted to our hospital from May 2014 to May 2015 were enrolled. The clinical data and surgical resection specimens of patients were collected. All patients were followed up for 3 years and the survival status of the patients was recorded. The relationship among MSI, BRAF V600E mutation and clinicopathological features were analyzed and compared. Furthermore the correlation of the value of BRAF V600E mutation in different microsatellite stable (MSS) subgroups with the prognosis of CRC patients was investigated as well. 【Results】Lymph node metastasis (N1) was more frequently observed in MSI-H patients, poorly differentiated tissues, BRAF V600E mutation and right-sided tumors were in a larger proportion in MSI-H patients. Compared to BRAF V600E wild type patients, the BRAF V600E mutant patients had a higher proportion of poorly differentiated cancer and lower disease-free survival rate. In the MSS group, the disease-free survival rate of patients with BRAF V600E mutation was significantly lower than that of BRAF V600E wild type patients. So BRAF V600E mutation was an independent risk factor for the prognosis of patients with CRC, especially MSS. 【Conclusion】Combining the detection of microsatellite instability and BRAF V600E mutation can effectively predict the prognosis of colorectal cancer patients. 2019 Vol. 36 (8): 1507-1509 [Abstract] ( 97 ) HTML (1 KB)  PDF  (0 KB)  ( 18 ) 1510 Perioperative Changes of T Cell Subsets in Patients with Intracranial Aneurysm Clipping WANG Guo-yan, CHEN Zhi-biao DOI: 10.3969/j.issn.1671-7171.2019.08.019 【Objective】To investigate the changes of T cell subsets in patients with intracranial aneurysm clipping during perioperative period. 【Methods】From January 2009 to January 2015, 80 patients with anterior circulation intracranial aneurysm occlusion in Wuhan University People's Hospital were selected as the study subjects (observation group), and 40 healthy persons in the same period were selected as the control group. The changes of CD3+, CD4+, CD8+ and CD4+/CD8+ T lymphocyte in peripheral blood of the two groups during the perioperative period were compared. 【Results】The number of CD3+, CD4+T, CD8+ lymphocyte and the ratio of CD4+/CD8+ in the observation group were not significantly different from those in the control group on the first day before operation (P>0.05); the number of CD3+, CD4+ T lymphocyte and the ratio of CD4+/CD8+ in the patients during operation and on the first day after operation were significantly lower than those on the first day before operation (P<0.05); the number of CD3+, CD4+T lymphocyte and the ratio of CD4+/CD8+ in the patients on the first day after operation were significantly lower than those on the first day before operation The number of CD8+ T lymphocyte was significantly lower than that during operation (P<0.05), but there was no significant change in the number of CD8+ T lymphocyte before and after operation (P>0.05). 【Conclusion】 In patients with intracranial aneurysm clamping, the cellular immune function during and after operation is low, and the cellular immune function after operation is lower than that during operation. 2019 Vol. 36 (8): 1510-1511 [Abstract] ( 89 ) HTML (1 KB)  PDF  (0 KB)  ( 14 ) 1512 Outcome Comparison between Conventional Approach and Modified Approach of Laparoscopic Biliary Exploration DENG An DOI: 10.3969/j.issn.1671-7171.2019.08.020 【Objective】To explore the effect of laparoscopic biliary exploration in the treatment of common bile duct stores under both conventional and modified approaches. 【Methods】Eighty-six patients with gallstones who underwent laparoscopic exploration were selected in our hospital. Patients were divided into experimental group and the control group, 43 cases in each group. The experimental group used a modified approach, while the control group used a conventional approach. The intraoperative blood loss, common bile duct suture time, gastrointestinal function recovery time, and hospitalization time were compared between the two groups. The levels of albumin (ALB) and total bilirubin (TBIL), complications and recurrence of stones were compared as well. 【Results】In the experimental group, the common bile duct suture time, incision length, gastrointestinal function recovery time and hospitalization time were lower than those in the control group(P<0.05). The levels of ALB after surgery in the two groups were higher than those before surgery, and the levels of TBIL after surgery in both groups were lower than those before surgery(P<0.05). However, there was no significant difference between the two groups either before or after surgery, respectively (P>0.05). The incidence of bile leakage, celiac bleeding, heart failure, urinary retention, and biliary stenosis was lower in the experimental group than in the control group, and the difference was statistically significant (P<0.05).【Conclusion】 Modified laparoscopic biliary exploration for the treatment of common bile duct stones can shorten the time of suturing of the common bile duct. The surgical incision is small, the incidence of postoperative complications is low, and the safety is high. It is worthy of clinical application. 2019 Vol. 36 (8): 1512-1513 [Abstract] ( 88 ) HTML (1 KB)  PDF  (0 KB)  ( 14 ) 1514 Comparison of Application Value of MRI and CT in the Diagnostic of Neonatal Hypoxic Ischemic Encephalopathy LIU Yang-yang, WANG Di DOI: 10.3969/j.issn.1671-7171.2019.08.021 【Objective】To explore the application value of magnetic resonance imaging (MRI) and CT in the diagnosis of neonatal hypoxic ischemic encephalopathy (HIE). 【Methods】A total of 70 neonates with HIE treated in our hospital from January 2016 to March 2018 were selected. All patients were examined by MRI and CT. The detection rates of MRI and CT for HIE detection, clinical index, subarachnoid hemorrhage, cerebral edema, basal ganglia hemorrhage, ventricular hemorrhage and ventricular dilatation were compared between the two groups. 【Results】The neonatal HIE detection rate of MRI was 100.00% (70/70), which was higher than that of CT 91.43% (64/70); the difference was statistically significant (χ2=4.353,P<0.05). The Kappa value of MRI and HIE clinical grading was 0.781 (P<0.05), which showed that the consistency was excellent. The Kappa value of CT and HIE clinical grading was 0.615 (P<0.05); the consistency was good. The MRI detection rate of subarachnoid hemorrhage was 25.71%, which was significantly higher than that of CT (11.43%,P<0.05); There were no significant differences in the detection rates of brain edema, basal ganglia hemorrhage, ventricular hemorrhage and ventricular dilatation between MRI and CT (P>0.05). 【Conclusion】Compared to CT examination, MRI has the advantages of high detection rate and high consistency with clinical classification in the diagnosis of neonatal HIE, which is suitable for clinical application. 2019 Vol. 36 (8): 1514-1516 [Abstract] ( 95 ) HTML (1 KB)  PDF  (0 KB)  ( 14 ) 1517 Application of Quantitative Ultrasound Elastography and Contrast-enhanced Ultrasonography in Evaluation of Neoadjuvant Radiotherapy and Chemotherapy for Rectal Cancer GAO Hui-rong, WU Chao-Sheng, WANG Hua, et al DOI: 10.3969/j.issn.1671-7171.2019.08.022 【Objective】To explore the value of ultrasound elastography and contrast-enhanced ultrasound quantification in the evaluation of neoadjuvant radiotherapy and chemotherapy for rectal cancer. 【Methods】A total of 77 patients with stage Ⅱ~Ⅲ rectal cancer in Anzhou District People's Hospital from September 2014 to June 2017 were selected as the subjects of study. All patients received preoperative neoadjuvant radiotherapy and chemotherapy before surgery. Before and after the treatment, the patients were examined quantitatively by ultrasound elastography and contrast-enhanced ultrasound. The changes of ultrasound parameters before and after the treatment and the consistency of T and N stages with pathology after the operation were observed. 【Results】 After treatment, the ADT, UES and ESR levels of all patients were significantly lower than those before treatment (P<0.05). After treatment, the scores of RI, AUC, PSV and AUC were lower than those before treatment, and the differences were statistically significant (P<0.05). After neoadjuvant therapy, the results of T-staging assessed by ultrasound were in good agreement with those of pathological examination (P<0.05), and the accuracy was 80.82%. After neoadjuvant therapy, the results of N-staging assessed by ultrasonography were in good agreement with those of pathological examination (P<0.05), and the accuracy was 82.19%. 【Conclusion】The contrast-enhanced ultrasound and ultrasound elastography can better reflect the preoperative neoadjuvant treatment effect of rectal cancer, which is conducive to the determination of preoperative staging and guidance of individualized treatment. 2019 Vol. 36 (8): 1517-1519 [Abstract] ( 104 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 1520 Diagnosis and Treatment of Cephalic Tetanus Developed after Endoscopic Sinus Surgery YAN Ting, SHEN Zhi-ying, WANG Fang DOI: 10.3969/j.issn.1671-7171.2019.08.023 【Objective】By analyzing the clinical characteristics of head tetanus and combining with literature, the experience of diagnosis and treatment of head tetanus after endoscopic sinus surgery was discussed. 【Methods】A 46-year-old male patient was diagnosed with head tetanus 26 days after endoscopic sinus surgery. He underwent anti-infection, tetanus antitoxin, sedation, tracheotomy and nutritional support.【Results】This patient with cephalic tetanus was successfully cured without sequelae. 【Conclusion】Early diagnosis and timely treatment are the key to successful treatment of rhinogenic head tetanus. Within one month after endoscopic sinus surgery, patients should avoid exposure to tetanus-enriched environment. 2019 Vol. 36 (8): 1520-1521 [Abstract] ( 81 ) HTML (1 KB)  PDF  (0 KB)  ( 14 ) 1522 Correlation between Serum Levels of Chemokine CCL5 and Metalloproteinase MMP-9 and Postoperative Recurrence of Human Non-small Cell Lung Cancer XUE Li-ying, ZHANG Meng, WANG Jue,et al DOI: 10.3969/j.issn.1671-7171.2019.08.024 【Objective】To study the expression of chemokine CCL5 and MMP-9 in serum of human non-small cell lung cancer and their relationship with the postoperative recurrence. 【Methods】A prospective cohort study was conducted to investigate the serum levels of CCL5 and MMP-9 in 103 patients with NSCLC. Serum samples of all patients were collected at 3 months after operation. Serum samples of 20 healthy subjects were collected to detect the levels of CCL5 and MMP-9 as well. The patients were divided into the high level group and low level group of CCL5 and MMP-9 based on the median level of serum CCL5 and MMP-9 at 3 months postoperation. After two years of follow-up, the difference in recurrence rates between high-level group and low-level group was observed, and the correlation between level of CCL5 and MMP-9 and postoperative recurrence rate was analyzed. 【Results】The recurrence rate of CCL5 high-level group was 53.12% (17/32), which was significantly higher than that of CCL5 low-level group (29.58%, 21/71). The difference was statistically significant (P<0.05). The recurrence rate of MMP-9 high-level group was 46.67% (14/30), which was higher than that of MMP-9 low level group (32.88%, 24/73). The difference was statistically significant (P<0.05).The Cox regression analysis showed that the high levels of serum CCL5 and MMP-9 after three months of operation were correlated to the recurrence of NSCLC (P<0.05). No other indexes were not associated with postoperative recurrence (P>0.05). 【Conclusion】The abnormal elevated levels of serum chemokine CCL5 and MMP-9 may play an important role in the occurrence and development of NSCLC. Detecting the changes of serum CCL5 and MMP-9 levels after operation may be helpful for early warning of tumor recurrence. 2019 Vol. 36 (8): 1522-1524 [Abstract] ( 96 ) HTML (1 KB)  PDF  (0 KB)  ( 15 ) 1525 Influencing Factors of Bone Mineral Density in Preeclampsia Pregnant Women WANG Yan, TANG Gui-e, TAO Cai-xia DOI: 10.3969/j.issn.1671-7171.2019.08.025 【Objective】To investigate ultrasound bone mineral density (BMD), serum calcium level and body mass index (BMI) in preeclampsia pregnant women. 【Methods】We selected 50 preeclampsia pregnant women from January 2017 to December 2017 as the observation group and 50 healthy pregnant women in our hospital during the same period as the control group. All patients underwent ultrasound bone mineral density (BMD) detection. According to the T value of the bone density of the pregnant women, the pregnant women in the observation group were divided into the normal bone group, the osteopenia group and the osteoporosis group. The bone mineral status, serum calcium, serum iron and body mass index (BMI) of the two groups were measured. Pearson correlation analysis was used to observe the correlation of BMD with serum calcium and body mass index. Logistic regression analysis of factors affecting the T value of bone mineral density in preeclampsia.【Results】The proportion of pregnant women with normal bone in the observation group was 28.00%, which was significantly lower than 76.00% in the control group, while the proportion of pregnant women with osteopenia and osteoporosis was significantly higher than that in the control group. There was no significant difference in the early pregnancy blood calcium and iron, and blood iron in late pregnancy between the two groups (P>0.05). The blood calcium in the late pregnancy and the BMI in the early pregnancy were both significantly lower than those in the control group. Correlation analysis showed that the bone density T value in the observation group was positively correlated with serum calcium concentration and BMI in early pregnancy. There were no significant differences in the age, height, early pregnancy weight, gestational age, pregnancy, birth, and gestational diabetes mellitus among the normal bone group, the osteopenia group and the osteoporosis group (P>0.05). However, there were significant differences in daily activity time, calcium supplement, vitamin supplement and calcium + vitamin supplement among the three groups (P<0.05). Multivariate logistic regression analysis showed that daily activity, vitamin supplementation, vitamin supplement and calcium plus vitamin supplementation were the factors influencing bone mineral density in pregnant women. 【Conclusion】Bone mineral density, serum calcium and body mass index are closely related during pregnancy. The change of bone mineral density can provide reference for the diagnosis of preeclampsia. Increasing daily activity time, calcium supplementation and vitamin supplementation can improve the bone mineral density of pregnant women, thereby reducing the risk of bone calcium loss leading to preeclampsia. 2019 Vol. 36 (8): 1525-1527 [Abstract] ( 105 ) HTML (1 KB)  PDF  (0 KB)  ( 14 ) 1528 Effects of Brushing Hands and Brushless Hands before Surgical Operation Disinfection on Hand-borne Bacteria and Hand Skin Situation during Surgery LI Ji, ZHONG Ling, GONG Ren-rong DOI: 10.3969/j.issn.1671-7171.2019.08.026 【Objective】To study the effects of brushing hands and brushless hands before surgical operation disinfection on hand-borne bacteria and hand skin situation during surgery. 【Methods】A total of 165 surgical operation personnel in our hospital from February 2016 to January 2018 were divided into the brushing hands group (n=80) and the brushless hands group (n=85) according to the hands brush status before surgical disinfection. The bacterial culture results before and after hands disinfection, microbiological conditions before hands disinfection, 1 min after disinfection, during surgery and after surgery, and hand skin self-evaluation table (HAS) in the two groups were compared. 【Results】 A large amount of bacteria grew in bacterial culture before hands disinfection in both groups。The bacterial culture results of hands after disinfection in the two groups were negative, which showed no bacteria growing in the culture solution. Before surgical operation disinfection, the microorganisms from the brushing hands group were significantly lower than those from the brushless hands group (P<0.05). After surgical disinfection, there was no significant difference in microbes between the two groups after 1 min, during surgery and after surgery (P>0.05). The hand comfort, appearance, humidity and integrity of the brushing hands group before surgical disinfection were significantly lower than those of the brushless hands group before surgical disinfection (P<0.05). 【Conclusion】Brushless hands before surgical operation disinfection does not increase the risk of hand-borne bacterial infection during surgery. Compared to hands brushing before surgical disinfection, brushless hands are less irritating to the skin of medical staff, easy to operate, and highly safe. 2019 Vol. 36 (8): 1528-1530 [Abstract] ( 108 ) HTML (1 KB)  PDF  (0 KB)  ( 15 ) 1531 Effect of Pivastatin Combined with Trimetazidine on Neuroendocrine Factor and Cardiac Function in Patients with Chronic Heart Failure TAN De-sheng, CAO Gang, XU Qiang,et al DOI: 10.3969/j.issn.1671-7171.2019.08.027 【Objective】To analyze the effects of Pivastatin combined with Trimetazidine on neuroendocrine factors and cardiac function in patients with chronic heart failure. 【Methods】One hundred and thirty-six patients with chronic heart failure admitted to our hospital were divided into observation group (trimetazidine + pitavastatin, n=70) and control group (trimetazidine, n=66) according to different medications. The cardiac function indexes [left ventricular end systolic diameter (LVESD), left ventricular end diastolic diameter (LVEDD) and left ventricular ejection fraction (LVEF)], 6-minute walking test, plasma levels of neuroendocrine factors [plasma atrial natriuretic peptide (ANP), plasma brain natriuretic peptide (BNP), plasma endothelin (ET)] were compared between the two groups before and after treatment. 【Results】After treatment, the LVEDD and LVESD of the two groups were lower than before treatment, and the LVEF was higher than before treatment, and the difference between the two groups was statistically significant (P<0.05). After treatment, the 6-minute walking distance of the observation group and the control group was greater than that before treatment, and the observation group was larger than that of the control group, the difference was statistically significant (P<0.05). After treatment, the levels of plasma ANP, BNP and ET in the two groups were lower than those before treatment, and those in the observation group were lower than those in the control group (P<0.05).【Conclusion】Pivastatin combined with trimetazidine can effectively inhibit the overactivation of neuroendocrine system and reverse ventricular remodeling in patients with chronic heart failure. It has a good effect and is worthy of clinical application. 2019 Vol. 36 (8): 1531-1532 [Abstract] ( 77 ) HTML (1 KB)  PDF  (0 KB)  ( 12 ) 1533 Effects of Risperidone Combined with Aripiprazole on Cognitive Function and Social Function in Patients with Chronic Schizophrenia ZHOU Bo, FENG Jie DOI: 10.3969/j.issn.1671-7171.2019.08.028 【Objective】To investigate the clinical effects of risperidone combined with aripiprazole in patients with chronic schizophrenia and its effects on cognitive function and social function. 【Methods】Fifty-four patients with chronic schizophrenia admitted to our hospital from June 2016 to May 2018 were divided into observation group (risperidone + aripiprazole) and control group (risperidone), 27 cases in each group. After 3 months of treatment, the cognitive function, social function and drug safety were compared between the two groups. 【Results】3 months after treatment, the scores of recognition, picture, association and back memory in Wechner memory scale (WMS) in the two groups were higher than those before treatment, and the scores in the observation group were higher than those in the control group, the difference was statistically significant (P<0.05). Three months after treatment, the scores of occupational function, parental intelligence, marriage intelligence, family activity, social withdrawal, self-care, responsibility, care and family intelligence in the social defect screening scale (SDSS) of the two groups were lower than those before treatment, and the observation group was lower than the control group, the difference was statistically significant (P<0.05). There was no significant difference in the incidence of blood pressure decrease, lethargy, abnormal electrocardiogram, nausea, vomiting and extrapyramidal reaction between the two groups (P>0.05).【Conclusion】Risperidone combined with aripiprazole in the treatment of chronic schizophrenia can effectively improve the cognitive and social functions of patients with less adverse drug reactions, which is worthy of promotion and application. 2019 Vol. 36 (8): 1533-1535 [Abstract] ( 100 ) HTML (1 KB)  PDF  (0 KB)  ( 16 ) 1536 Application of Nutritional Intervention Combined with Isometric Resistance Exercise in Gestational Diabetes Patients WANG Li DOI: 10.3969/j.issn.1671-7171.2019.08.029 【Objective】To explore the effects of nutritional intervention combined with isometric resistance exercise on serum adipokines and glycemic control in patients with gestational diabetes (GDM). 【Methods】A total of 146 patients with gestational diabetes admitted from October 2015 to October 2016 were enrolled. They were divided into the treatment group and the control group with 73 cases each, using random number table method. Patients in the control group received routine nursing interventions including health education, psychological care, birth examination and blood glucose testing, and routine nutritional guidance. The treatment group applied nutritional intervention combined with isometric resistance exercise. Serum adipokines, blood glucose control levels, and pregnancy outcomes were compared between the two groups. 【Results】In the treatment group, serum adiponectin level was significantly higher than that in the control group, while levels of visfatin, leptin, group (P<0.01); fasting blood glucose (FPG), 2h postprandial blood glucose (2hPG) and glycosylated hemoglobin (HbA1c) in the control were significantly lower than those in the control group (P<0.05). The incidence of premature rupture of membranes, cesarean section, macrosomia and hyperbilirubinemia in the treatment group were significantly lower than those in the control group (P<0.05). 【Conclusion】Nutritional intervention combined with isometric resistance exercise can inhibit the secretion of serum adipokines in patients with gestational diabetes, promote glycemic control and improve pregnancy outcomes. 2019 Vol. 36 (8): 1536-1538 [Abstract] ( 89 ) HTML (1 KB)  PDF  (0 KB)  ( 12 )

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