Abstract【Objective】To investigate the clinical effects of risperidone combined with aripiprazole in patients with chronic schizophrenia and its effects on cognitive function and social function. 【Methods】Fifty-four patients with chronic schizophrenia admitted to our hospital from June 2016 to May 2018 were divided into observation group (risperidone + aripiprazole) and control group (risperidone), 27 cases in each group. After 3 months of treatment, the cognitive function, social function and drug safety were compared between the two groups. 【Results】3 months after treatment, the scores of recognition, picture, association and back memory in Wechner memory scale (WMS) in the two groups were higher than those before treatment, and the scores in the observation group were higher than those in the control group, the difference was statistically significant (P<0.05). Three months after treatment, the scores of occupational function, parental intelligence, marriage intelligence, family activity, social withdrawal, self-care, responsibility, care and family intelligence in the social defect screening scale (SDSS) of the two groups were lower than those before treatment, and the observation group was lower than the control group, the difference was statistically significant (P<0.05). There was no significant difference in the incidence of blood pressure decrease, lethargy, abnormal electrocardiogram, nausea, vomiting and extrapyramidal reaction between the two groups (P>0.05).【Conclusion】Risperidone combined with aripiprazole in the treatment of chronic schizophrenia can effectively improve the cognitive and social functions of patients with less adverse drug reactions, which is worthy of promotion and application.
ZHOU Bo,FENG Jie. Effects of Risperidone Combined with Aripiprazole on Cognitive Function and Social Function in Patients with Chronic Schizophrenia[J]. JOURNAL OF CLINICAL RESEARCH, 2019, 36(8): 1533-1535.
[1] 李新纯,李庆,王超英,等.银杏叶胶囊联合阿立哌唑对精神分裂症患者认知功能的影响[J].中医杂志,2016,57(18):1583-1586. [2] 高丽娟,郭华贵,梁震韬,等.阿立哌唑对男性精神分裂症患者继发药源性性功能障碍的影响[J].中华男科学杂志,2017,23(7):615-619. [3] Miura I, Bundo M, Hino M,et al.PM516. Association of DNA methylation of taq1a in the DRD2 with response to aripiprazole in acute schizophrenia [J].Int J Neuropsychopharmacol,2016,19(Suppl 1):87. [4] 赵晶媛,黄光彪,顾小静,等.4种第二代抗精神病药物治疗精神分裂症急性期的临床观察[J].中国药房,2016,27(20):2790-2794. [5] Citrome L, Ota A, Nagamizu K,et al.The effect of brexpiprazole (OPC-34712) and aripiprazole in adult patients with acute schizophrenia: results from a randomized, exploratory study[J].Int Clin Psychopharmacol,2016,31(4):192. [6] 蔡晓楠,何学莲,吴革菲,等.阿立哌唑治疗儿童Tourette综合征的疗效及安全性分析[J].中华实用儿科临床杂志,2016,31(18):1426-1431. [7] 张艳,康传媛,元静,等. COMT基因多态性与阿立哌唑治疗精神分裂症临床疗效及认知功能的关联性分析[J].中华行为医学与脑科学杂志,2017,26(1):32-36.
[1]
. [J]. JOURNAL OF CLINICAL RESEARCH, 2019, 36(8): 1637-1638.
2019, Vol. 36 
