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| Association between Polymorphism of Tumor Necrosis Factor-inducible Protein 3 Gene and Genetic Susceptibility to Allergic Rhinitis |
| LIANG Rong-fang |
| Guangyuan Hospital of Traditional Chinese Medicine,Sichuan Guangyuan 628000 China |
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Abstract 【Objective】To investigate the relationship between gene polymorphism of tumor necrosis factorαinduced protein 3 (TNFAIP3) and genetic susceptibility to allergic rhinitis (AR).【Methods】From January 2016 to August 2017, the blood samples of 200 patients with AR (observation group) and 200 healthy volunteers (control group) were selected as the subjects.Four polymorphism loci (rs5029928,rs9494885,rs610604,rs7753873) of TNFAIP3 gene in DNA samples extracted from anticoagulant were genotyped by restriction fragment length polymorphism polymerase chain reaction (PCR-RFLP) and direct sequencing.【Results】The genotypes of four polymorphic loci of TNFAIP3 gene in both groups were in accordance with Hardy Weinberg equilibrium, and there were significant differences in allele and genotype frequencies of rs94885 locus between the two groups. The frequency of ACA haplotype in the observation group was significantly lower than that in the control group (P<0.05), and the frequency of TCCA haplotype was significantly higher than that in the control group (P<0.05). There was no significant difference in other indicators between the two groups (P>0.05).【Conclusion】There is a significant correlation between AR and TNFAIP3 gene polymorphism, and the rs94885 polymorphism of TNFAIP3 is closely related to AR susceptibility.
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Received: 24 August 2018
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2019, Vol. 36 
