Home  |  About Journal  |  Editorial Board  |  Instruction  |  Subscribe  |  Advertisement  |  Messages Board  |  Contact Us  |  中文

Forthcoming Articles    Current Issue    Archive    Advanced Search    Read Articles    Download Articles    Email Alert

Quick Search     Adv Search 2015 Vol. 32, No. 8 Published: 2015-08-26   1457 Analysis of The Dominant and Recessive Hemorrhage in Stabilizing Femoral Intertrochanteric Fractures in Elder Patients Treated with two Type Internal Fixations Hot! ZHENG Lian sheng,XIANG Bao guo,LIN Hao DOI: 16717171.2015.08.001 【Objective】To analyze the dominant and recessive blood loss in stabilizing femoral intertrochanteric fractures in elder patients treated with two types of internal fixations (DHS versus PFNA).【Methods】A total of 134 elder patients with stabilizing femoral intertrochanteric fractures treated with DHS or PFNA were selected from our hospital from January 2010 to January 2014. The total perioperative blood loss was conculated by Gross equation based on patients' heights, weights, and pre and postoperative complete blood counts. The risk factors that impact the recessive hemorrhage in elder patients with stabilizing femoral intertrochanteric fractures were analyzed.【Results】The average operation time（77.23±26.3 minutes) of DHS group was significantly longer than that (61.05±19.29 minutes) of PFNA group; the dominant hemorrhage of DHS group (141.53±79.51 mL) was markedly more than that of PFNA group (97.05±86.19 mL); the recessive blood loss（387.67±311.05）mL and total amount hemorrhage（529.20±442.24 mL) of DHS group were statistically significant less than those (655.71±492.90 mL and 752.76±597.69 mL, respectively) of PFNA group (P<0.05). There is no statistically significance of the recessive blood loss among the 4 subtypes in both DHS and PFNA groups (P>0.05); However, the recessive blood loss in each subtype of DHS group was significantly less than that of each corresponding subtype of PFNA group (P<0.05). Age, operation time, and internal fixation methods were the independent risk factors that resulted in recessive hemorrhage in stabilizing femoral intertrochanteric fractures in elder patients.【Conclusion】The complications caused by massive hemorrhage in patients older than 75 years who had stabilizing femoral intertrochanteric fractures, if DHS is used for internal fixation with shortening the operation time and intensifying postoperative cares. 2015 Vol. 32 (8): 1457-1664 [Abstract] ( 101 ) HTML (1 KB)  PDF  (0 KB)  ( 41 ) 1460 A Study of Curative Effect of Calcitriol Pulse Therapy on Hemodialysis Secondary Hyperparathyroidism Hot! SU Hui DOI: 16717171.2015.08.002 【Objective】To study the effect of calcitriol pulse therapy on hemodialysis secondary hyperparathyroidism and their levels of parathyroid hormone , serum calcium and serum phosphorus. 【Methods】 90 cases of patients with hemodialysis secondary hyperparathyroidism in our hospital were enrolled and randomly divided into two grups,the observation group and the control group，45 cases for each them. The observation group received calcitriol pulse dosage therapy, while control group received conventional calcitriol dosage therapy . The results of parathyroid hormone , serum calcium and serum phosphorus , bone metabolic index and advervse reactions were compared. 【Results】①parathyroid hormone:4, 8, 12 weeks after treatment, parathyroid hormone levels of the observation group were lower than those of the control group （405.62±50.62 vs 514.74±61.48, 335.93±45.96 vs 441.38±56.23, 241.87±39.43 vs 352.58±49.62）pg/mL;②serum calcium and serum phosphorus: serum calcium level of the observation group was higher than that of the control group (2.49±0.35 vs 2.21±0.25) mmol/L, and serum phosphorus level was even lower than that of the control group (1.21±0.16 vs 1.78±0.24) mmol/L;③bone metabolism index: serum BALP and OC contents of the observation group were lower than those of the control group ［(24.59±4.95 vs 50.66±6.78) U/L, (4.49±0.62 vs 8.87±0.94) μg/L］ ,the difference hereby was significant (P<0.05);④Adverse reactions: the observation group was 2.22%, significantly lower than the control group 17.78%, the difference hereby was significant（χ2=6.049,P<0.05）. 【Conclusions】Calcitriol pulse therapy is helpful to reduce PTH level, regulate calcium and phosphorus balance, improve bone metabolism; it's an ideal method in treating hemodialysis secondary hyperparathyroidism. 2015 Vol. 32 (8): 1460-1463 [Abstract] ( 148 ) HTML (1 KB)  PDF  (0 KB)  ( 44 ) 1463 About OneStage Approach Combined Posterior and Anterior Intervertebral Autogenous Iliac Bone Graft for Treatment of Children Lumbar Tuberculosis Hot! YANG Li bin, LU Tan, YANG Su min DOI: 16717171.2015.08.003 【Objective】To investigate the safety and clinical effect of OneStage approach combined posterior and anterior intervertebral autogenous iliac bone graft for the treatment of lumbar tuberculosis in children.【Methods】13 cases of patients from 7 to 14 years old ( average age about 11.5) have received preoperative anti tuberculosis treatment ever lasted 2 to 4 weeks before the OneStage operation: posterior pedicle screw fixation, anterior debridement of tuberculosis focus, intervertebral autogenous iliac bone graft. All patients had 6 to 8 weeks postoperative bed rest plus antituberculosis treatment lasted 12~18 months.【Results】The period followup was 20~28 months and all operation incisions healed up primarily, without neurological progress and sinus tractor fistulae formation. The height of vertebral body and the correction of the posterior deformity were satisfactory, and there was no displacement of bone graft, and the patients have solid bony fusion after 4 to 7 months. 6 cases with neurological symptoms had recovered with neither kyphosis deformity progress nor internal fixation loosening nor rupture after operation. The tuberculosis foci were healed up, there was no obvious abnormality of the vertebral body, and no obvious abnormality was found in the pelvis.【Conclusion】The One Stage approach combined posterior and anterior with intervertebral autogenous iliac bone graft proved to be a safe and effective method for the treatment of children's lumbar tuberculosis, which can abolish tuberculosis foci , fully decompress for spinal cord, effectively correct the deformity of the spine and prevent the development of the spine deformity. 2015 Vol. 32 (8): 1463-1467 [Abstract] ( 100 ) HTML (1 KB)  PDF  (0 KB)  ( 44 ) 1468 Application of Intensivecare Delirium Screening Score In The Treatment of Acute Organophosphorus Pesticide Poisoning Patients Hot! SHEN Ying|nian, CHEN Wei, ZHOU Lin DOI: 16717171.2015.08.004 【Objective】To define the effects of intensive care delirium screening checklist（ICDSC）on delirium caused by penehyclidine hydrochloride in patients with acute organophosphorus poisoning（AOPP）.【Methods】One hundred and twenty cases of acute organophosphorus poisoning patients from May, 2011 to August ,2014 were randomly assigned into two groups: controlled group, treated with penehyclidine hydrochloride as regular (n=62) and observed group, treated with penehyclidine hydrochloride guided by ICDSC (n=58). Then according to the degree of poisoning , the two groups were respectively divided into light, middle, and severe subgroups. The start of delirium , the degree and duration of delirium, the disappear time of muscarinic symptoms, the recovery time of cholinesterase and duration of the hospital staying were analyzed.【Results】The observed group had significantly improvement in the duration of time and the degree of delirium compared to the controlled group for middle and severe subgroups (P<0.05), the hospital stays of the observed group is shorter significantly (P<0.05) ,while the two groups had no difference in cure rate(P>0.05).【Conclusion】When treat acute organophosphorus poisoning patients，the dosage of penehyclidine hydrochloride, the degree of delirium and the duration of hospital stay can be reduced guided by ICDSC. 2015 Vol. 32 (8): 1468-1470 [Abstract] ( 73 ) HTML (1 KB)  PDF  (0 KB)  ( 37 ) 1471 Animal Model of Spinal Cord Injury Hot! DOI: 16717171.2015.08.005 【Objective】 To established mild, moderate and severe models of spinal cord injury with a MASCIS impactor.  【Methods】 In female adult SpragueDawley rats, T10 spinous process and the corresponding vertebral lamina were removed and spinal cord endorhachis was exposed. Three levels of injury were inflicted to rat spinal cord by dropping a 10g rod 12.5, 25.0 or 50.0 mm on to exposed spinal cord. The control group underwent T10~11 laminectomies alone. The behavioral scores and pathological alterations were recorded at different timepoints. 【Results】 In control group, the rats could walk after reviving and the microstructure of spinal cord was normal. Group A (12.5 mm), 1 month after operation, movement function was almost restored, the score of Basso, Beattie & Bresnahan (BBB) was 17.34±1.00, microstructure of spinal cord was distinct, glial cell hyperplasia; group B (25 mm), 1 month after operation, the score of BBB was 7.32±1.12, lacunar formation, glial cell hyperplasia and several variant neurons were present in microstructure of spinal cord; group C (50 mm), 1 month after operation, the score of BBB was 4.87±0.31, residue spinal cord tissues were less abundant than group B. The spinal cord structure was disorderly and seriously deformed. The necrotic cavity accounted for about 80% of spinal cord. The grading differences were statistically significant between groups A, B and C and normal control (P<0.05）. 【Conclusion】 The models of three levels of mild, moderate and severe injury made by a MASCIS impactor are stable, reliable and reproducible. they can used for elucidating the mechanism of spinal cord injury, pathophysiological changes and different treatments. 2015 Vol. 32 (8): 1471-1474 [Abstract] ( 79 ) HTML (1 KB)  PDF  (0 KB)  ( 38 ) 1474 Study on Total Dose of Crystalloid Solution Infusion during Surgery in Patients Undergoing Laparoscopic Cholecystectomy Hot! WU Xuelan, WU Zheng DOI: 16717171.2015.08.006 【Objective】To investigate the effects of total dose of crystalloid solution infusion during surgery in patients undergoing laparoscopic cholecystectomy.【Methods】A total number of 156 cases of patients undergoing laparoscopic cholecystectomy in our hospital from January 2012 to September 2014 were randomly and equally divided into restricting group and opening group by random number table, resulting in 78 cases in each group. Patients in restricting group were infused Lactated Ringer's solution 5 mL/(kg•h), while patients in opening group were infused 30 mL/(kg•h). Heart rate (HR), mean artery pressure (MAP), and complication rate were recorded. Visual analogue scale (VAS) was used to evaluate the pain scale at 1, 6, 24 hours postoperatively.【Results】The VAS scores and hidrosis symptom in restricting group were significantly higher than that in opening group at 6 hours postsurgery (P<0.05). No statistic significant difference on HR, MAP, and hospital stays was observed between two groups (P＞0.05).【Conclusion】Restricting Lactated Ringer's solution infusion during surgery could aggravate postoperative pain and hidrosis symptoms when compare to nonrestriction of infusion. Both methods have no impacts on HR, MAP, and hospital stays. 2015 Vol. 32 (8): 1474-1476 [Abstract] ( 89 ) HTML (1 KB)  PDF  (0 KB)  ( 42 ) 1477 Expressions and Significances of BrainDerived Neurotrophic Factor and Tyrosine Kinase Receptor B in Endometrial Carcinoma Hot! CHEN Xu na, YE Zhi zhong DOI: 16717171.2015.08.007 【Objective】 To explore the expressions of brainderived neurotrophic factor (BDNF) and tyrosine kinase receptor B (TrkB) in endometrial carcinoma and analyze their clinical significances. 【Methods】 The expressions of BDNF and TrkB were detected by immunohistochemistry in normal endometrium (n=22), hyperplasia endometrium (n=32) and endometrial carcinoma (n=62). And the relationship with their clinicopathological characteristics were analyzed. 【Results】 BDNF and TrkB were negatively or weakly positively expressed in normal endometrium while positively in hyperplasia endometrium and endometrial carcinoma. And statistically significant differences existed among three groups (P<0.05). The expressions of BDNF and TrkB in endometrial carcinoma were significantly correlated with tumor cell differentiation, clinicopathologic staging, myometrial invasion and lymph node metastasis of endometrial carcinoma (P<0.05). 【Conclusion】 The interaction of BDNF with TrkB may play an important synergistic role in the occurrence and development of endometrial carcinoma. 2015 Vol. 32 (8): 1477-1479 [Abstract] ( 39 ) HTML (1 KB)  PDF  (0 KB)  ( 31 ) 1480 Biomechanics Analysis Of Tibial Plateau Tip Point Of Knee Anterior Cruciate Ligament Hot! WANG Jing WANG Yu si DAI Chang DOI: 16717171.2015.08.008 【Objective】 To analyze the biomechanical properties in different movement planes of tibial plateau tip point of anteromedial and posterolateral bundle of anterior cruciate ligament (ACL) and explore the optimal tip point during tendon reconstruction. 【Methods】 Retrospective analyses were conducted for knee magnetic resonance imaging (MRI) scans of 253 cases scheduled for exploration of knee arthroscopy from June 2010 to October 2012. And the parameters of length, thickness, width of anteromedial and posterolateral bundle of ACL and the length between posterior and anterior of tibial tip point were measured. Knees and ACLs were harvested voluntarily from 10 fresh cadaveric donors. And anatomical characteristics of different parts of ACL were analyzed. The pulloff test was performed, loadextension curve plotted and maximum strain and maximum stress calculated. 【Results】 MRI showed that ACL was divided by tibial tip point into posterior (2/3 of ACL) (22.916±2.963 mm) and anterior(1/3 ACL) (13.096±1.759 mm) parts. Biomechanical test showed maximum stress and maximum strain of anteromedial bundle, including anterior tibial tip point, were 38.843±4.152 N/mm2 and 47.895±3.141% and posterolateral bundle 30.260±2.242 N/mm2 and 40.705±2.535% respectively. And maximum stress and maximum strain of anteromedial bundle were larger than those of posterolateral bundle (P<0.05). 【Conclusion】 The anteromedial bundle of ACL, including anterior tibial tip point, is a major stress point in different movement planes. And anterior ACL tibial tip point may be an optimal site for ACL reconstruction. 2015 Vol. 32 (8): 1480-1482 [Abstract] ( 101 ) HTML (1 KB)  PDF  (0 KB)  ( 53 ) 1483 Expressions and Significance of Ezrin And Cd44v6 in Skin Basal Cell Cancer and Squamous Cell Cancer Hot! JIANG Su, LI Dong xia DOI: 16717171.2015.08.009 【Objective】 To explore the expressions and significance of Ezrin protein and CD44v6 in basal cell cancer (BCC) and squamous cell cancer (SCC). 【Methods】 The expressions of Ezrin protein and CD44v6 were detected in 32 SCC, 30 BCC and 10 normal skin (NS) samples by immunohistochemistry SP . 【Results】 The positive ratios of Ezrin were 60.0%, 84.4% and 10% in BCC, SCC and NS respectively. The expression of Ezrin was closely correlated with pathological grading of SCC and lymphatic metastasis. The positive ratios of CD44v6 in BCC, SCC and NS were 26.7%, 59.4% and 100%. The expression of CD44v6 was downregulated with a decrease of SCC differentiation degree. The positive expressions of Ezrin and CD44v6 in BCC and SCC were correlated (rs1=0.336, rs2=0.278,P<0.05). 【Conclusion】 Ezrin and CD44v6 may be used as molecular biological markers of occurrence and development for SCC and BCC. 2015 Vol. 32 (8): 1483-1485 [Abstract] ( 81 ) HTML (1 KB)  PDF  (0 KB)  ( 43 ) 1486 An Analysis of  Serum Creatinine and Urea nitrogen in IschemiaReperfusion on  Mice Kidney Injury Hot! An Analysis of  Serum Creatinine and Urea nitrogen in IschemiaReperfusion on  Mice Kidney Injury[J]. 医学临床研究, 2015,32(8): 1486-1489')" href="#"> DING Niu LI Zhi hui DENG Xu DOI: 16717171.2015.08.010 【Objective】To investigate the occurrence and progress of serum creatinine and urea nitrogen in ischemiareperfusion of mice kidney injury.【Methods】Male mice (C57BL/6J) used as subjects were randomly distributed in three groups: the ischemiareperfusion group (IR), the sham surgery group (S) and the control group (C), and the SCr and UN levels of the 3 groups at different time points and the their kidney /lung tissue pathological damage were detected and analyzed.【Results】Levels of SCr and UN showed no significant difference in the Group C and the Group S (P>0.05). From 0h to 7d following reperfusion, the SCr and UN levels gradually increased and then decreased, and reached the peak value 24h after reperfusion . The interstitial damage score of renal tubules and pathological damage score of lung injury at different time points presented comparatively no significant difference between group C and group S (P >0.05). The IR Group presents the same tendency ,increasing first ,than decreasing ,the pathological grading of renal tubular interstitial injury reached the peak value 24h after reperfusion; Pathological damage score of lung injury reached the peak value in 48～72 h.【Conclusion】The mice model of ischemiareperfusion renal injury is one steady animal model for research of Acute kidney injury（AKI）， and ischemia AKI may induce pulmonary inflammatory reaction, and bring out acute kidney injury（AKI）as well. 2015 Vol. 32 (8): 1486-1489 [Abstract] ( 124 ) HTML (1 KB)  PDF  (0 KB)  ( 0 ) 1490 Clinical Characters of Pneumonia with Pulmonary Consolidation in Different Age Groups of Children XU Chang RAO Huaping DOI: 16717171.2015.08.011 【Objective】To explore the clinical characters of pneumonia with pulmonary consolidation in children.【Methods】Case series analysis method was used, and 128 cases with pulmonary consolidation in pneumonia from August, 2012 to August, 2014 were retrospectively investigated.【Results】The WBC level of <1 and 1～3 years old children with pneumonia and lung consolidation were respectively 49.0% and 57.6%. There was a significant difference between these two group (P<0.05). The hospitalization of <1 years old children with pneumonia and lung consolidation was significantly longer than 3~5 and ≥5 years old children. The need of mechanical ventilation and the occurrence of bronchitis obliterans in the children with pneumonia and lung consolidation were highest. Streptococcus pneumonia (9 case, 7.0%), adenovirus (16 case, 12.5%) and mycoplasma (51 case, 39.8%) were the most common infections. The proportion of using mechanical ventilation and fiberoptic bronchoscopy of bronchitis obliterans in the children with pneumonia and lung consolidation were significantly higher than the others (P<0.05), so were the days of hospitalization and the duration of fever after admission.【Conclusion】Infants with pneumonia accompanied with lung consolidation should be paid more attention. Streptococcus pneumoniae, adenovirus and mycoplasma were the most common etiology. In addition, children used mechanical ventilation with pneumonia accompanied with lung consolidation should be given early intervention and comprehensive treatment so as to prevent the occurrence of ronchitis obliterans. 2015 Vol. 32 (8): 1490-1496 [Abstract] ( 107 ) HTML (1 KB)  PDF  (0 KB)  ( 39 ) 1493 An Analysis of Abnormal Expression of Tumor Markers in Different Kinds of Tuberculosis Patients Hot! Wu Xiaokang YIN Jiafeng ZHANG Rongqiang DOI: 16717171.2015.08.012 【Objective】 To explore the significance and characteristics of four tumor markers like CEA, NSE, CYF211 and CA125 in clinical differentiation and diagnosis of patients with tuberculosis. 【Methods】145 cases of patients with tuberculosis confirmed by clinic were collected, and 60 cases of patients with pulmonary tumor plus 60 cases of healthy control group were also collected. The serum content of the four tumor markers like CEA, NSE, CYF211 and CA125 of the three groups were detected by electrochemical fluorescence immunoassay; The situation of the four markers was compared within patients of tuberculosis, pulmonary tumor and the healthy control group respectively; The differences of the four markers were compared in patients with three kinds of tuberculosis like pulmonary tuberculosis, obsolete pulmonary tuberculosis and tuberculous pleurisy; The differences of the four markers in the sample of serum and in the sample of pleuroperitoneal effusion of tuberculosis patients were also compared. 【Results】 Contents of NSE and CA125 in serum of tuberculosis patients were obviously higher than those of the healthy control, and the difference is significant（P＜0.05）; CA125 of tuberculosis patients was even higher than that of pulmonary tumor patients （P＜0.05）; There were no difference among patients with different kinds of tuberculosis with the exception of CEA（P＜0.05）; Contents of CEA and NSE in serum sample were significantly higher than those in pleuroperitoneal effusion（P＜0.05）, while contents of CYE211and CA125 in serum sample were remarkably higher than those in pleuroperitoneal effusion sample（P＜0.05）.【Conclusions】CA125 can be considered as an indicator of differentiation and diagnosis of tuberculosis. The result can be more accurate through the collection and detection of serum sample. The results would be more accurate if serum sample is collected and detected. Besides, NSE can also be chosen as an indicator of differentiation and diagnosis of tuberculosis diseases, whose optimal originality of sample collection shall come from pleuroperitoneal effusion. 2015 Vol. 32 (8): 1493-1496 [Abstract] ( 94 ) HTML (1 KB)  PDF  (0 KB)  ( 34 ) 1497 Effect of Different Timing and Diseases on Hysterosalpingography Imaging WANG Chen LIU Meiqiu YUAN Ji an DOI: 16717171.2015.08.013 【Objective】To discuss the effect of different timing and diseases on hysterosalpingography imaging.【Methods】1005 infertile cases who needed hysterosalpingography were collected , and the effect of different timing and different relevant diseases on hysterosalpingography imaging was analyzed.【Results】There is no obvious correlation between the outcomes of grading comparison of fallopian tubes regarding the number of menstruation clean days on operation, the patient's endometrial thickness, pelvic effusion, ect（P>0.05）. However, there were significant differences in the grading of the primary infertility and secondary infertility (P<0.05). 【Conclusion】The number of menstruation clean days on operation, the patient's endometrial thickness, pelvic effusion would not effect the imaging of hysterosalpingography. 2015 Vol. 32 (8): 1497-1499 [Abstract] ( 73 ) HTML (1 KB)  PDF  (0 KB)  ( 46 )

Copyright © Editorial Board of JOURNAL OF CLINICAL RESEARCH Supported by:Beijing Magtech