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Abstract 【Objective】 To explore the expressions and significance of Ezrin protein and CD44v6 in basal cell cancer (BCC) and squamous cell cancer (SCC). 【Methods】 The expressions of Ezrin protein and CD44v6 were detected in 32 SCC, 30 BCC and 10 normal skin (NS) samples by immunohistochemistry SP . 【Results】 The positive ratios of Ezrin were 60.0%, 84.4% and 10% in BCC, SCC and NS respectively. The expression of Ezrin was closely correlated with pathological grading of SCC and lymphatic metastasis. The positive ratios of CD44v6 in BCC, SCC and NS were 26.7%, 59.4% and 100%. The expression of CD44v6 was downregulated with a decrease of SCC differentiation degree. The positive expressions of Ezrin and CD44v6 in BCC and SCC were correlated (rs1=0.336, rs2=0.278,P<0.05). 【Conclusion】 Ezrin and CD44v6 may be used as molecular biological markers of occurrence and development for SCC and BCC.
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Received: 28 July 2014
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2015, Vol. 32 
