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| A Study of Curative Effect of Calcitriol Pulse Therapy on Hemodialysis Secondary Hyperparathyroidism |
| Department of Renal medicine, Hefei First People's Hospital, Anhui Hefei 230062, China |
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Abstract 【Objective】To study the effect of calcitriol pulse therapy on hemodialysis secondary hyperparathyroidism and their levels of parathyroid hormone , serum calcium and serum phosphorus. 【Methods】 90 cases of patients with hemodialysis secondary hyperparathyroidism in our hospital were enrolled and randomly divided into two grups,the observation group and the control group，45 cases for each them. The observation group received calcitriol pulse dosage therapy, while control group received conventional calcitriol dosage therapy . The results of parathyroid hormone , serum calcium and serum phosphorus , bone metabolic index and advervse reactions were compared. 【Results】①parathyroid hormone:4, 8, 12 weeks after treatment, parathyroid hormone levels of the observation group were lower than those of the control group （405.62±50.62 vs 514.74±61.48, 335.93±45.96 vs 441.38±56.23, 241.87±39.43 vs 352.58±49.62）pg/mL;②serum calcium and serum phosphorus: serum calcium level of the observation group was higher than that of the control group (2.49±0.35 vs 2.21±0.25) mmol/L, and serum phosphorus level was even lower than that of the control group (1.21±0.16 vs 1.78±0.24) mmol/L;③bone metabolism index: serum BALP and OC contents of the observation group were lower than those of the control group ［(24.59±4.95 vs 50.66±6.78) U/L, (4.49±0.62 vs 8.87±0.94) μg/L］ ,the difference hereby was significant (P<0.05);④Adverse reactions: the observation group was 2.22%, significantly lower than the control group 17.78%, the difference hereby was significant（χ2=6.049,P<0.05）. 【Conclusions】Calcitriol pulse therapy is helpful to reduce PTH level, regulate calcium and phosphorus balance, improve bone metabolism; it's an ideal method in treating hemodialysis secondary hyperparathyroidism.
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Received: 04 June 2015
Published: 26 August 2015
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2015, Vol. 32 
