五阶梯营养支持对胃癌术后辅助化疗患者营养状态及化疗毒副反应的影响

doi:10.3969/j.issn.1671-7171.2024.10.031

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摘要【目的】探讨五阶梯营养支持对胃癌术后辅助化疗患者营养状态及化疗毒副反应的影响。【方法】行胃癌术后辅助化疗的80例患者,随机分成两组,每组40例。观察组给予五阶梯营养支持,对照组给予常规营养支持,比较两组干预前后营养状态、血液生化指标水平、化疗毒副反应和生存质量。【结果】干预后,两组主观整体营养状况评估量表(PG-SGA)评分降低,体重指数(BMI)、小腿最大周径升高(P<0.05),且观察组PG-SGA评分低于对照组,BMI、小腿最大周径高于对照组(P<0.05);干预后,两组血红蛋白(Hb)、血清白蛋白(Alb)、血清前蛋白(PA)水平较干预前均升高(P<0.05),且观察组高于对照组(P<0.05);观察组化疗毒副反应总发生率(17.50%)低于对照组(45.00%)(P<0.05);干预后3个月、6个月,两组胃癌患者生命质量测量量表评分均低于干预前,且观察组低于对照组(P<0.05)。【结论】在胃癌术后辅助化疗患者中应用五阶梯营养支持可以改善患者营养状态、血液生化指标,减轻化疗毒副反应,改善患者生存质量,值得临床推广应用。

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	车帅
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关键词 ：胃肿瘤/外科学, 抗肿瘤联合化疗方案, 营养支持, 药物相关性副作用和不良反应

Abstract：【Objective】 To investigate the impact of five-step nutritional support on the nutritional status and side effects in patients undergoing postoperative adjuvant chemotherapy for gastric cancer. 【Methods】 Eighty patients undergoing postoperative adjuvant chemotherapy for gastric cancer were randomly divided into two groups, with 40 patients in each group. The observation group received five-step nutritional support, while the control group received conventional nutritional support. The nutritional status, blood biochemical indicators, chemotherapy side effects, and quality of life were compared between the two groups before and after the intervention. 【Results】After the intervention, the overall nutritional status subjective scoring (PG-SGA) decreased, while body mass index (BMI) and maximum calf circumference increased in both groups (P<0.05). The PG-SGA score in the observation group was lower than that in the control group, while both BMI and maximum calf circumference were higher in the observation group compared to the control group (P<0.05). After the intervention, hemoglobin (Hb), serum albumin (Alb), and serum prealbumin (PA) levels increased in both groups compared to before the intervention (P<0.05), and levels of Hb, Alb and PA in the observation group were higher than those in the control group (P<0.05). The overall incidence of chemotherapy side effects in the observation group (17.50%) was lower than that in the control group (45.00%) (P<0.05). At 3 and 6 months after the intervention, the scores of the Quality of Life Questionnaire for Gastric Cancer Patients in both groups were lower than those before the intervention, and the observation group's scores were lower than those of the control group (P<0.05). 【Conclusion】 The application of five-step nutritional support in patients undergoing postoperative adjuvant chemotherapy for gastric cancer can improve nutritional status, enhance blood biochemical indicators, reduce side effects, and improve the quality of life, making it worthy of clinical promotion and application.

Key words： Stomach Neoplasms/SU Antineoplastic Combined Chemotherapy Protocols Nutritional Support Drug-Related Side Effects and Adverse Reactions

收稿日期: 2024-05-10

中图分类号:

R735.2

通讯作者: *E-mail:zhangyuanch@163.com

引用本文:

车帅, 鹿伦杰, 姜潇, 张媛春. 五阶梯营养支持对胃癌术后辅助化疗患者营养状态及化疗毒副反应的影响[J]. 医学临床研究, 2024, 41(10): 1564-1567.
CHE Shuai, LU Lunjie, JIANG Xiao, et al. Effect of Five-Step Nutritional Support on the Nutritional Status and Chemotherapy Side Effects in Patients Undergoing Postoperative Adjuvant Chemotherapy for Gastric Cancer. JOURNAL OF CLINICAL RESEARCH, 2024, 41(10): 1564-1567.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2024.10.031 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2024/V41/I10/1564

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