戈舍瑞林联合腹腔镜手术治疗子宫内膜异位症合并不孕症患者的临床疗效及安全性观察

doi:10.3969/j.issn.1671-7171.2024.07.024

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摘要【目的】探讨戈舍瑞林联合腹腔镜手术治疗子宫内膜异位症合并不孕症患者的临床疗效及安全性。【方法】选取2019年7月至2020年7月本院收治的88例子宫内膜异位症合并不孕症患者,按照随机数字表法分为观察组(采用戈舍瑞林联合腹腔镜手术治疗)与对照组(采用腹腔镜手术治疗),每组44例。比较两组治疗效果、治疗期间不良反应总发生率、术后2年的子宫内膜异位症复发率和妊娠率及治疗前和治疗后6个月血清卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E₂)、谷胱甘肽过氧化酶(GSH-PX)、活性氧簇(ROS)水平。【结果】观察组总有效率显著高于对照组(P<0.05)。治疗后,两组FSH、LH、E₂、ROS水平显著低于治疗前,且观察组FSH、LH、E₂、ROS水平低于对照组(P<0.05);治疗后,两组GSH-PX水平显著高于治疗前,且观察组GSH-PX水平高于对照组。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。观察组复发率显著低于对照组(P<0.05),妊娠率显著高于对照组(P<0.05)。【结论】戈舍瑞林联合腹腔镜手术在子宫内膜异位症合并不孕症患者的治疗中效果较好,可调节患者性激素水平,改善氧化应激反应,降低复发率,提高妊娠率,且安全性较好。

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	刘莉
	石光辉
	郑振丽

关键词 ：子宫内膜异位症/外科学, 不育,女性, 戈舍瑞林/治疗应用, 腹腔镜检查, 治疗结果

Abstract：【Objective】 To explore the clinical efficacy and safety of goserelin combined with laparoscopic surgery in the treatment of endometriosis complicated with infertility patients.【Methods】A total of 88 patients with endometriosis complicated with infertility admitted to our hospital from July 2019 to July 2020 were randomly divided into the observation group (treated with goserelin combined with laparoscopic surgery) and the control group (treated with laparoscopic surgery) according to a random number table method, with 44 cases in each group. Two groups were compared in terms of treatment efficacy, overall incidence of adverse reactions during treatment, recurrence rate and pregnancy rate of endometriosis 2 years after surgery, as well as serum follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E₂), glutathione peroxidase (GSH-PX), and reactive oxygen species (ROS) levels before and 6 months after treatment.【Result】The total effective rate of the observation group was significantly higher than that of the control group (P<0.05). After treatment, the levels of FSH, LH, E₂, and ROS in both groups were significantly lower than before treatment, and the levels of FSH, LH, E₂, and ROS in the observation group were lower than those in the control group (P<0.05); After treatment, the levels of GSH-PX in both groups were significantly higher than before treatment, and the observation group had higher levels of GSH-PX than the control group. There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P>0.05). The recurrence rate of the observation group was significantly lower than that of the control group (P<0.05), and the pregnancy rate was significantly higher than that of the control group (P<0.05). 【Conclusion】 The combination of goserelin and laparoscopic surgery is effective in the treatment of endometriosis complicated with infertility. It can regulate the patient's sex hormone levels, improve oxidative stress response, reduce recurrence rate, increase pregnancy rate, and has good safety.

Key words： Endometriosis/SU Infertility, Female Goserelin/TU Laparoscopy Treatment Outcome

收稿日期: 2022-09-06

中图分类号:

R711.71

引用本文:

刘莉, 石光辉, 郑振丽. 戈舍瑞林联合腹腔镜手术治疗子宫内膜异位症合并不孕症患者的临床疗效及安全性观察[J]. 医学临床研究, 2024, 41(7): 1044-1047.
LIU Li, SHI Guanghui, ZHENG Zhenli. Clinical Efficacy and Safety Observation of Goserelin Combined with Laparoscopic Surgery in the Treatment of Endometriosis Complicated with Infertility Patients. JOURNAL OF CLINICAL RESEARCH, 2024, 41(7): 1044-1047.

链接本文:

http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2024.07.024 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2024/V41/I7/1044

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