Abstract：【Objective】To explore the value of serum fetal hemoglobin (HbF), alpha fetoprotein (AFP), combined with fetal biophysical score (BPS) and Apgar score in the diagnosis of fetal maternal transfusion syndrome (FMH) in pregnant and postpartum women. 【Methods】A total of 100 pregnant and postpartum women suspected of FMH were selected as the study subjects in our outpatient department. After delivery, the serum HbF and AFP levels of pregnant and postpartum women were measured, and they were divided into FMH group (13 cases) and non FMH group (87 cases) based on the test results; We compared the HbF, AFP levels, BPS, and Apgar scores between two groups of pregnant women. The value of HbF, AFP, BPS, and Apgar scores in predicting FMH was analyzed using Receiver Operating Characteristic (ROC) curves; The multiple factor analysis adopted unconditional logistic stepwise regression analysis. 【Results】The levels of HbF and AFP in the FMH group were significantly higher than those in the non FMH group, and the BPS and Apgar scores were significantly lower than those in the non FMH group (all P<0.05); According to ROC analysis, HbF, AFP, BPS, and Apgar scores can be used to predict the occurrence of FMH. The area under the curve was 0.897, 0.810, 0.829, and 0.941, respectively, and the area under the joint diagnostic curve was 0.980; Multiple logistic regression analysis confirmed that HbF≤3.712%, AFP≤588.359 ng/mL, BPS≥5.865 scores, and Apgar score ≥5.96 scores were risk factors for the occurrence of FMH.【Conclusion】The combination of serum HbF, AFP, BPS, and Apgar score can be used for early diagnosis of FMH, and the combined detection has better evaluation efficacy.
2024, Vol. 41 
