医学临床研究
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医学临床研究  2024, Vol. 41 Issue (1): 85-87    DOI: 10.3969/j.issn.1671-7171.2024.01.023
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超声检查联合血清CEA、AFP在乳腺癌鉴别诊断中的应用价值
田秀丽, 李劲松*
西安宝石花长庆医院功能科,陕西 西安 710201
The Value of Ultrasonography Combined with Serum CEA and AFP Levels in the Differential Diagnosis of Breast Cancer
TIAN Xiuli, LI Jinsong
Xi'an Baoshihua Changqing Hospital,Xi'an Shaanxi 710201
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摘要 【目的】 探讨超声检查联合癌胚抗原(CEA)和甲胎蛋白(AFP)对乳腺癌的临床诊断价值。【方法】 选取2019年4月至2023年4月本院收治的90例乳腺癌患者(乳腺癌组)及87例乳腺良性结节患者(乳腺良性结节组),另选取同期100例健康女性志愿者(对照组)。所有研究对象均行超声检查及血清CEA、AFP水平检测,采用受试者工作特征(ROC)曲线分析超声检查联合CEA、AFP对乳腺癌的临床诊断价值。【结果】 乳腺癌组Vmax、血流阻力指数(RI)、搏动指数(PI)均明显高于乳腺良性结节组及对照组,差异有统计学意义(P<0.05)。乳腺癌组血清CEA、AFP水平均显著高于乳腺良性结节组及对照组,差异有统计学意义(P<0.05)。超声检查联合CEA、AFP对乳腺癌的诊断价值较高(AUC=0.930),且预测灵敏度、特异度分别为93.0%、97.5%,均高于任一单项检测指标(P<0.05)。【结论】 超声检查联合CEA、AFP在乳腺癌的诊断中具有较高的临床价值,相较于单一检测,其联合应用可以显著提高乳腺癌的诊断灵敏度和特异度。
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田秀丽
李劲松
关键词 结节病/诊断乳腺疾病/诊断乳腺肿瘤/诊断超声检查癌胚抗原/血液甲胎蛋白类/血液    
Abstract:【Objective】 To investigate the clinical diagnostic value of ultrasonography combined with carcinoembryonic antigen (CEA) and alpha fetoprotein (AFP) in breast cancer. 【Methods】 A total of 90 patients with breast cancer (breast cancer group, n=90) and 87 patients with benign breast nodules (benign breast nodules group, n=87) admitted to our hospital from April 2019 to April 2023 were selected, and 100 healthy female volunteers (control group) were selected in the same period. All subjects were examined by ultrasound and serum CEA and AFP levels. The clinical diagnostic value of ultrasound combined with CEA and AFP in breast cancer was analyzed by receiver operating characteristic (ROC) curve. 【Results】 Vmax, RI and PI in breast cancer group were significantly higher than those in the benign breast nodules group and the control group (P<0.05). Serum CEA and AFP levels in the breast cancer group were significantly higher than those in the benign breast nodules group and the control group (P<0.05). Ultrasound combined with CEA and AFP had the highest diagnostic value for breast cancer (AUC=0.930), and the predictive sensitivity was 93.0% and 97.5%, respectively, which were higher than any single detection index (P<0.05). 【Conclusion】 Ultrasonography combined with CEA and AFP has high clinical value in the diagnosis of breast cancer. Compared with single detection, its combined application can significantly improve the diagnostic sensitivity and specificity of breast cancer.
Key wordsSarcoidosis/DI    Breast Diseases/DI    Breast Neoplasms/DI    Ultrasonography    Carcinoembryonic Antigen/BL    alpha-Fetoproteins/BL
收稿日期: 2023-08-06     
中图分类号:  R737.9  
通讯作者: *E-mail:1908800184@qq.com   
引用本文:   
田秀丽, 李劲松. 超声检查联合血清CEA、AFP在乳腺癌鉴别诊断中的应用价值[J]. 医学临床研究, 2024, 41(1): 85-87.
TIAN Xiuli, LI Jinsong. The Value of Ultrasonography Combined with Serum CEA and AFP Levels in the Differential Diagnosis of Breast Cancer. JOURNAL OF CLINICAL RESEARCH, 2024, 41(1): 85-87.
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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2024.01.023     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2024/V41/I1/85
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